ENSG00000131148

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000253457 ENSG00000131148 No_inf pgKDN_inf EMC8 protein_coding protein_coding 23.31417 24.47739 20.35296 1.764535 0.7614457 -0.2660917 10.815087 5.3364703 14.1974162 1.0214879 1.4615312 1.4099856 0.48907500 0.212875 0.706325 0.493450 2.784103e-03 6.935411e-15 FALSE TRUE
ENST00000435200 ENSG00000131148 No_inf pgKDN_inf EMC8 protein_coding protein_coding 23.31417 24.47739 20.35296 1.764535 0.7614457 -0.2660917 4.521952 6.1235635 4.2257497 1.3289319 1.4519969 -0.5341082 0.19405000 0.264725 0.200750 -0.063975 8.586189e-01 6.935411e-15 FALSE FALSE
ENST00000595980 ENSG00000131148 No_inf pgKDN_inf EMC8 protein_coding nonsense_mediated_decay 23.31417 24.47739 20.35296 1.764535 0.7614457 -0.2660917 4.543317 9.2815359 0.0000000 0.9925359 0.0000000 -9.8597733 0.17925000 0.377275 0.000000 -0.377275 6.935411e-15 6.935411e-15 TRUE FALSE
ENST00000596852 ENSG00000131148 No_inf pgKDN_inf EMC8 protein_coding retained_intron 23.31417 24.47739 20.35296 1.764535 0.7614457 -0.2660917 1.513435 0.9689536 1.0640385 0.5596153 1.0640385 0.1337333 0.05762500 0.036450 0.049600 0.013150 8.433006e-01 6.935411e-15 FALSE FALSE
ENST00000600807 ENSG00000131148 No_inf pgKDN_inf EMC8 protein_coding retained_intron 23.31417 24.47739 20.35296 1.764535 0.7614457 -0.2660917 1.397615 2.2098174 0.4943561 0.7912972 0.1821483 -2.1379263 0.05684167 0.085125 0.024675 -0.060450 4.092869e-01 6.935411e-15   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000131148 E001 0.6164191 0.0157641492 0.5690698090 0.80616526 16 85771758 85771891 134 - 0.165 0.250 0.753
ENSG00000131148 E002 0.4992005 0.0157164408 0.2680668684   16 85776555 85776606 52 - 0.090 0.250 1.753
ENSG00000131148 E003 35.4514469 0.0157885475 0.9908154167 1.00000000 16 85778624 85779397 774 - 1.560 1.563 0.008
ENSG00000131148 E004 30.6880348 0.0021832725 0.1190971715 0.36473720 16 85779398 85779640 243 - 1.538 1.459 -0.271
ENSG00000131148 E005 15.1646903 0.0009736710 0.9264291764 0.97796194 16 85779641 85779661 21 - 1.204 1.212 0.028
ENSG00000131148 E006 40.3150143 0.0007930784 0.1940596814 0.47391509 16 85779662 85779867 206 - 1.587 1.644 0.194
ENSG00000131148 E007 1.4758851 0.0110965589 0.4459386448 0.72033469 16 85779868 85780378 511 - 0.333 0.450 0.653
ENSG00000131148 E008 15.2863011 0.0010142187 0.7104713222 0.88296362 16 85780379 85780473 95 - 1.198 1.226 0.099
ENSG00000131148 E009 1.4899798 0.1249131713 0.2459813932 0.53665803 16 85780474 85781210 737 - 0.284 0.488 1.168
ENSG00000131148 E010 18.7115301 0.0214626506 0.7908643544 0.91986924 16 85781211 85781280 70 - 1.284 1.305 0.074
ENSG00000131148 E011 2.7524718 0.0075301388 0.0009247072 0.01414841 16 85781281 85781760 480 - 0.284 0.754 2.338
ENSG00000131148 E012 0.7350599 0.0544901316 0.8990266383 0.96692902 16 85788897 85788973 77 - 0.229 0.250 0.168
ENSG00000131148 E013 10.0227888 0.0017499169 0.9440643078 0.98455047 16 85788974 85789050 77 - 1.039 1.046 0.027
ENSG00000131148 E014 30.6424128 0.0004811224 0.0217645333 0.13391406 16 85799065 85799608 544 - 1.552 1.439 -0.388

Help

Please Click HERE to learn more details about the results from DEXseq.