ENSG00000133740

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000256117 ENSG00000133740 No_inf pgKDN_inf E2F5 protein_coding nonsense_mediated_decay 2.380495 2.412828 2.731611 0.6411482 0.1763565 0.178332 0.65457397 0.60359053 0.6526676 0.15120798 0.1088753 0.1110091 0.30015833 0.295575 0.250125 -0.045450 1.0000000000 0.0006469842 TRUE TRUE
ENST00000416274 ENSG00000133740 No_inf pgKDN_inf E2F5 protein_coding protein_coding 2.380495 2.412828 2.731611 0.6411482 0.1763565 0.178332 0.17893131 0.03939313 0.4272041 0.03939313 0.2466841 3.1459245 0.07463333 0.021425 0.162275 0.140850 0.7233760299 0.0006469842 FALSE TRUE
ENST00000418930 ENSG00000133740 No_inf pgKDN_inf E2F5 protein_coding protein_coding 2.380495 2.412828 2.731611 0.6411482 0.1763565 0.178332 0.26651285 0.00000000 0.2220809 0.00000000 0.2220809 4.5365561 0.13713333 0.000000 0.082425 0.082425 0.8456587160 0.0006469842 FALSE TRUE
ENST00000517476 ENSG00000133740 No_inf pgKDN_inf E2F5 protein_coding protein_coding 2.380495 2.412828 2.731611 0.6411482 0.1763565 0.178332 0.51919998 0.00000000 0.9156713 0.00000000 0.3765564 6.5324281 0.19644167 0.000000 0.313250 0.313250 0.1060138376 0.0006469842 FALSE TRUE
ENST00000518234 ENSG00000133740 No_inf pgKDN_inf E2F5 protein_coding protein_coding 2.380495 2.412828 2.731611 0.6411482 0.1763565 0.178332 0.14575930 0.43727791 0.0000000 0.43727791 0.0000000 -5.4830996 0.03362500 0.100875 0.000000 -0.100875 0.8313908214 0.0006469842 FALSE TRUE
ENST00000520225 ENSG00000133740 No_inf pgKDN_inf E2F5 protein_coding protein_coding 2.380495 2.412828 2.731611 0.6411482 0.1763565 0.178332 0.44418888 1.33256665 0.0000000 0.29032200 0.0000000 -7.0688499 0.19404167 0.582125 0.000000 -0.582125 0.0006469842 0.0006469842 FALSE FALSE
ENST00000521234 ENSG00000133740 No_inf pgKDN_inf E2F5 protein_coding retained_intron 2.380495 2.412828 2.731611 0.6411482 0.1763565 0.178332 0.04222205 0.00000000 0.1266661 0.00000000 0.1266661 3.7725840 0.01858333 0.000000 0.055750 0.055750 0.8370945062 0.0006469842   FALSE
ENST00000521429 ENSG00000133740 No_inf pgKDN_inf E2F5 protein_coding protein_coding 2.380495 2.412828 2.731611 0.6411482 0.1763565 0.178332 0.12910713 0.00000000 0.3873214 0.00000000 0.3873214 5.3122345 0.04538333 0.000000 0.136150 0.136150 0.8549386233 0.0006469842 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000133740 E001 0.1268540 0.012855008 3.307488e-01   8 85177154 85177224 71 + 0.000 0.101 9.337
ENSG00000133740 E002 0.2356421 0.016681200 4.469687e-01   8 85177225 85177611 387 + 0.163 0.000 -13.521
ENSG00000133740 E003 0.0000000       8 85177612 85177654 43 +      
ENSG00000133740 E004 0.0000000       8 85187685 85187796 112 +      
ENSG00000133740 E005 0.2454921 0.017183833 7.214097e-01   8 85201785 85202146 362 + 0.089 0.101 0.210
ENSG00000133740 E006 0.8539541 0.013847643 8.269464e-01 9.373403e-01 8 85202147 85202256 110 + 0.281 0.253 -0.206
ENSG00000133740 E007 2.1507471 0.011069564 3.866912e-02 1.902530e-01 8 85203094 85203255 162 + 0.645 0.253 -2.112
ENSG00000133740 E008 0.0000000       8 85203256 85203262 7 +      
ENSG00000133740 E009 0.0000000       8 85206163 85206176 14 +      
ENSG00000133740 E010 1.4148045 0.014281152 1.319739e-03 1.856031e-02 8 85206177 85206220 44 + 0.572 0.000 -15.192
ENSG00000133740 E011 0.0000000       8 85206221 85206224 4 +      
ENSG00000133740 E012 0.9416260 0.014447440 1.160039e-02 8.864252e-02 8 85207425 85207489 65 + 0.450 0.000 -14.865
ENSG00000133740 E013 0.4746825 0.074533183 1.292896e-01   8 85209142 85209212 71 + 0.281 0.000 -14.209
ENSG00000133740 E014 1.9026637 0.009803827 1.798717e-02 1.182563e-01 8 85209213 85209409 197 + 0.622 0.184 -2.598
ENSG00000133740 E015 0.3516386 0.018572070 2.280109e-01   8 85212157 85212159 3 + 0.226 0.000 -13.948
ENSG00000133740 E016 1.2935104 0.014361686 2.250257e-03 2.793218e-02 8 85212160 85212204 45 + 0.545 0.000 -15.124
ENSG00000133740 E017 0.8360726 0.016016751 1.573383e-01 4.239125e-01 8 85212205 85213752 1548 + 0.374 0.101 -2.375
ENSG00000133740 E018 2.4999142 0.030911959 1.450128e-02 1.026933e-01 8 85213753 85213902 150 + 0.707 0.253 -2.375
ENSG00000133740 E019 1.9176058 0.111324597 1.273121e-01 3.784002e-01 8 85213903 85214159 257 + 0.598 0.253 -1.907
ENSG00000133740 E020 13.2525493 0.001340275 1.886276e-13 2.691386e-11 8 85214160 85216124 1965 + 0.974 1.288 1.129
ENSG00000133740 E021 3.0709719 0.006003934 7.448889e-02 2.782962e-01 8 85216125 85216307 183 + 0.545 0.671 0.557
ENSG00000133740 E022 0.0000000       8 85216960 85217158 199 +      

Help

Please Click HERE to learn more details about the results from DEXseq.