ENSG00000133789

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000318950 ENSG00000133789 No_inf pgKDN_inf SWAP70 protein_coding protein_coding 26.48493 16.15998 31.96539 0.4964734 0.8166443 0.9836445 18.365868 10.466703 20.869061 0.3026107 1.3231060 0.9948721 0.6870250 0.6505 0.654150 0.003650 1.000000e+00 5.668672e-09 FALSE TRUE
ENST00000447399 ENSG00000133789 No_inf pgKDN_inf SWAP70 protein_coding protein_coding 26.48493 16.15998 31.96539 0.4964734 0.8166443 0.9836445 4.707339 0.000000 8.366729 0.0000000 1.2399436 9.7102432 0.1496000 0.0000 0.262350 0.262350 5.668672e-09 5.668672e-09 FALSE TRUE
ENST00000534562 ENSG00000133789 No_inf pgKDN_inf SWAP70 protein_coding nonsense_mediated_decay 26.48493 16.15998 31.96539 0.4964734 0.8166443 0.9836445 2.523034 5.121479 1.620323 0.7800944 0.9750964 -1.6542173 0.1294417 0.3136 0.048925 -0.264675 6.907896e-02 5.668672e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000133789 E001 0.1268540 1.230657e-02 2.635182e-01   11 9664077 9664080 4 + 0.000 0.128 10.839
ENSG00000133789 E002 0.1268540 1.230657e-02 2.635182e-01   11 9664081 9664101 21 + 0.000 0.128 12.769
ENSG00000133789 E003 0.9806820 1.222293e-02 3.568973e-01 6.466898e-01 11 9664102 9664134 33 + 0.231 0.374 0.960
ENSG00000133789 E004 7.6037108 2.585058e-02 4.356525e-01 7.122678e-01 11 9664135 9664278 144 + 0.949 0.854 -0.363
ENSG00000133789 E005 12.6179455 1.129712e-03 4.143694e-02 1.977053e-01 11 9694146 9694286 141 + 1.172 0.995 -0.643
ENSG00000133789 E006 0.0000000       11 9703396 9703448 53 +      
ENSG00000133789 E007 14.8742381 9.473317e-04 7.345718e-01 8.946701e-01 11 9713466 9713639 174 + 1.192 1.166 -0.093
ENSG00000133789 E008 0.6015365 4.745113e-02 5.208376e-01 7.749818e-01 11 9720066 9720483 418 + 0.231 0.128 -1.040
ENSG00000133789 E009 25.3691266 6.715839e-04 4.330627e-01 7.105596e-01 11 9724658 9724885 228 + 1.419 1.372 -0.166
ENSG00000133789 E010 0.1272623 1.236568e-02 2.634381e-01   11 9724886 9725055 170 + 0.000 0.128 12.768
ENSG00000133789 E011 0.1186381 1.185877e-02 1.000000e+00   11 9726895 9726955 61 + 0.070 0.000 -12.415
ENSG00000133789 E012 24.6465184 6.656731e-04 7.451429e-03 6.590446e-02 11 9728053 9728199 147 + 1.445 1.273 -0.597
ENSG00000133789 E013 18.3331315 4.822778e-03 3.621548e-01 6.513598e-01 11 9729343 9729451 109 + 1.292 1.223 -0.244
ENSG00000133789 E014 24.2349016 6.173872e-03 2.624953e-01 5.553282e-01 11 9732529 9732710 182 + 1.411 1.332 -0.272
ENSG00000133789 E015 22.5181141 5.816536e-04 4.770715e-02 2.147957e-01 11 9738213 9738320 108 + 1.396 1.265 -0.455
ENSG00000133789 E016 30.2295520 3.255772e-03 5.261846e-01 7.786252e-01 11 9740181 9740342 162 + 1.489 1.452 -0.128
ENSG00000133789 E017 9.6673053 1.492271e-03 6.079852e-01 8.292158e-01 11 9740343 9740347 5 + 1.027 0.979 -0.178
ENSG00000133789 E018 5.6258325 8.735800e-03 6.251341e-02 2.511676e-01 11 9740348 9741953 1606 + 0.717 0.930 0.834
ENSG00000133789 E019 31.1735164 4.775767e-04 3.751188e-01 6.627219e-01 11 9747858 9748056 199 + 1.506 1.457 -0.168
ENSG00000133789 E020 19.2992621 7.822653e-04 2.139634e-01 4.991821e-01 11 9749087 9749183 97 + 1.319 1.232 -0.306
ENSG00000133789 E021 43.6623965 3.591474e-04 6.742968e-02 2.619573e-01 11 9749864 9750283 420 + 1.660 1.574 -0.293
ENSG00000133789 E022 337.4339525 7.755905e-05 7.349760e-08 4.419197e-06 11 9750284 9752993 2710 + 2.487 2.550 0.210

Help

Please Click HERE to learn more details about the results from DEXseq.