ENSG00000134317

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000324907 ENSG00000134317 No_inf pgKDN_inf GRHL1 protein_coding protein_coding 0.5955449 0.7353847 0.5049792 0.08247952 0.01441122 -0.533471 0.07266947 0.00000000 0.2180084 0.00000000 0.12679968 4.5110151 0.1514000 0.000000 0.4542 0.454200 0.54269804 0.03292067 FALSE TRUE
ENST00000405379 ENSG00000134317 No_inf pgKDN_inf GRHL1 protein_coding protein_coding 0.5955449 0.7353847 0.5049792 0.08247952 0.01441122 -0.533471 0.06491082 0.03631353 0.0000000 0.03631353 0.00000000 -2.2114338 0.1270083 0.041475 0.0000 -0.041475 0.92768127 0.03292067 FALSE TRUE
ENST00000472167 ENSG00000134317 No_inf pgKDN_inf GRHL1 protein_coding nonsense_mediated_decay 0.5955449 0.7353847 0.5049792 0.08247952 0.01441122 -0.533471 0.06745451 0.00000000 0.1476276 0.00000000 0.08561818 3.9784483 0.1273667 0.000000 0.2788 0.278800 0.47784533 0.03292067 TRUE TRUE
ENST00000480736 ENSG00000134317 No_inf pgKDN_inf GRHL1 protein_coding protein_coding 0.5955449 0.7353847 0.5049792 0.08247952 0.01441122 -0.533471 0.27046324 0.54649488 0.0000000 0.10407786 0.00000000 -5.7982965 0.3813667 0.727250 0.0000 -0.727250 0.03292067 0.03292067 FALSE FALSE
ENST00000497403 ENSG00000134317 No_inf pgKDN_inf GRHL1 protein_coding retained_intron 0.5955449 0.7353847 0.5049792 0.08247952 0.01441122 -0.533471 0.12004686 0.15257629 0.1393432 0.04194277 0.05798868 -0.1224854 0.2128583 0.231275 0.2670 0.035725 0.85314455 0.03292067 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000134317 E001 0.1170040 0.012449162 0.697569599   2 9951693 9951781 89 + 0.099 0.000 -11.538
ENSG00000134317 E002 0.1170040 0.012449162 0.697569599   2 9951782 9951853 72 + 0.099 0.000 -13.274
ENSG00000134317 E003 0.0000000       2 9952907 9953060 154 +      
ENSG00000134317 E004 0.1176306 0.012574876 0.697195375   2 9954915 9955101 187 + 0.099 0.000 -13.274
ENSG00000134317 E005 0.3533378 0.017971204 0.158354767   2 9958786 9958856 71 + 0.248 0.000 -14.143
ENSG00000134317 E006 0.0000000       2 9958857 9958964 108 +      
ENSG00000134317 E007 0.0000000       2 9958965 9960963 1999 +      
ENSG00000134317 E008 0.0000000       2 9960964 9961045 82 +      
ENSG00000134317 E009 0.4812643 0.022017688 0.454429360   2 9961046 9961164 119 + 0.248 0.091 -1.728
ENSG00000134317 E010 0.7273180 0.020333412 0.597483365 0.8233137 2 9961165 9961436 272 + 0.307 0.166 -1.144
ENSG00000134317 E011 0.3542802 0.020874760 0.159178358   2 9962455 9962531 77 + 0.248 0.000 -14.143
ENSG00000134317 E012 0.1265070 0.013382280 0.399266685   2 9963886 9964042 157 + 0.000 0.091 11.336
ENSG00000134317 E013 0.2451451 0.018639190 0.826200465   2 9964235 9964346 112 + 0.099 0.091 -0.143
ENSG00000134317 E014 0.0000000       2 9964347 9965286 940 +      
ENSG00000134317 E015 0.2459004 0.018116031 0.828978434   2 9965287 9965381 95 + 0.099 0.091 -0.143
ENSG00000134317 E016 0.0000000       2 9965382 9966401 1020 +      
ENSG00000134317 E017 0.1272623 0.013218549 0.400230180   2 9986124 9986282 159 + 0.000 0.091 11.336
ENSG00000134317 E018 0.1176306 0.012574876 0.697195375   2 9990696 9990747 52 + 0.099 0.000 -13.274
ENSG00000134317 E019 0.0000000       2 9990748 9990773 26 +      
ENSG00000134317 E020 0.2346346 0.017211331 0.342271107   2 9992007 9992146 140 + 0.180 0.000 -13.848
ENSG00000134317 E021 0.1170040 0.012449162 0.697569599   2 9993207 9993244 38 + 0.099 0.000 -13.274
ENSG00000134317 E022 0.0000000       2 9995306 9995360 55 +      
ENSG00000134317 E023 0.2441403 0.018051644 0.825639203   2 9995879 9995970 92 + 0.099 0.091 -0.143
ENSG00000134317 E024 0.0000000       2 9996316 9996401 86 +      
ENSG00000134317 E025 0.0000000       2 9998965 9999029 65 +      
ENSG00000134317 E026 3.5827566 0.005008682 0.004556117 0.0463991 2 10000593 10002277 1685 + 0.583 0.715 0.567

Help

Please Click HERE to learn more details about the results from DEXseq.