ENSG00000135446

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000257904 ENSG00000135446 No_inf pgKDN_inf CDK4 protein_coding protein_coding 65.21773 37.44157 78.39014 0.7924648 3.732735 1.06583 44.543823 30.622501 49.714228 1.0574596 1.6097562 0.6988858 0.71024167 0.820225 0.641350 -0.178875 1.463377e-01 1.827306e-10 FALSE TRUE
ENST00000546489 ENSG00000135446 No_inf pgKDN_inf CDK4 protein_coding protein_coding 65.21773 37.44157 78.39014 0.7924648 3.732735 1.06583 5.854410 0.000000 9.812846 0.0000000 0.8297927 9.9399973 0.07407500 0.000000 0.126200 0.126200 1.827306e-10 1.827306e-10 FALSE FALSE
ENST00000547853 ENSG00000135446 No_inf pgKDN_inf CDK4 protein_coding protein_coding 65.21773 37.44157 78.39014 0.7924648 3.732735 1.06583 3.766101 3.213737 3.660984 2.0509033 2.3415727 0.1874329 0.06110833 0.083675 0.044025 -0.039650 9.557912e-01 1.827306e-10   FALSE
ENST00000552254 ENSG00000135446 No_inf pgKDN_inf CDK4 protein_coding protein_coding 65.21773 37.44157 78.39014 0.7924648 3.732735 1.06583 4.946825 1.108330 5.003651 0.7700652 2.3039610 2.1645157 0.06654167 0.029575 0.062650 0.033075 8.210889e-01 1.827306e-10 FALSE FALSE
ENST00000553237 ENSG00000135446 No_inf pgKDN_inf CDK4 protein_coding nonsense_mediated_decay 65.21773 37.44157 78.39014 0.7924648 3.732735 1.06583 3.044648 0.000000 7.150448 0.0000000 2.6738712 9.4839060 0.03820833 0.000000 0.087175 0.087175 3.118522e-02 1.827306e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000135446 E001 0.0000000       12 57747727 57748410 684 -      
ENSG00000135446 E002 0.0000000       12 57748411 57748425 15 -      
ENSG00000135446 E003 0.0000000       12 57748426 57748519 94 -      
ENSG00000135446 E004 0.0000000       12 57748520 57748590 71 -      
ENSG00000135446 E005 0.0000000       12 57748591 57748617 27 -      
ENSG00000135446 E006 0.0000000       12 57749182 57749190 9 -      
ENSG00000135446 E007 0.0000000       12 57749191 57749219 29 -      
ENSG00000135446 E008 0.0000000       12 57749220 57749233 14 -      
ENSG00000135446 E009 0.0000000       12 57749234 57749317 84 -      
ENSG00000135446 E010 0.0000000       12 57749454 57749504 51 -      
ENSG00000135446 E011 0.0000000       12 57749505 57749795 291 -      
ENSG00000135446 E012 1.4764467 0.0090067412 0.109286993 0.34701018 12 57750442 57750563 122 - 0.279 0.521 1.363
ENSG00000135446 E013 5.9499701 0.0025510023 0.620750729 0.83611133 12 57750656 57750668 13 - 0.807 0.864 0.219
ENSG00000135446 E014 5.4779942 0.0028569902 0.344732447 0.63586160 12 57750669 57750671 3 - 0.755 0.864 0.425
ENSG00000135446 E015 8.1589323 0.0017385760 0.181718770 0.45773544 12 57750672 57750678 7 - 0.895 1.026 0.488
ENSG00000135446 E016 39.9844898 0.0003716461 0.081037135 0.29248858 12 57750679 57750765 87 - 1.565 1.648 0.282
ENSG00000135446 E017 0.6339843 0.0156175636 0.003045191 0.03489823 12 57750827 57750922 96 - 0.000 0.425 12.274
ENSG00000135446 E018 31.2225049 0.0004857161 0.177915686 0.45269164 12 57750923 57750933 11 - 1.465 1.538 0.251
ENSG00000135446 E019 74.9237959 0.0002179311 0.551676856 0.79550521 12 57750934 57751090 157 - 1.857 1.879 0.073
ENSG00000135446 E020 23.3719570 0.0005918622 0.971554315 0.99453344 12 57751207 57751214 8 - 1.372 1.372 -0.001
ENSG00000135446 E021 44.2524498 0.0003514871 0.279703333 0.57292608 12 57751215 57751296 82 - 1.657 1.611 -0.158
ENSG00000135446 E022 32.4376333 0.0004526040 0.619758935 0.83549117 12 57751297 57751342 46 - 1.518 1.494 -0.082
ENSG00000135446 E023 1.9861512 0.2464101037 0.069968608 0.26763014 12 57751343 57751499 157 - 0.279 0.667 2.015
ENSG00000135446 E024 55.3728331 0.0002972833 0.302040270 0.59523810 12 57751500 57751659 160 - 1.750 1.711 -0.132
ENSG00000135446 E025 22.3693685 0.0007333514 0.490624242 0.75317587 12 57751660 57751696 37 - 1.369 1.327 -0.146
ENSG00000135446 E026 14.3593165 0.0057457930 0.263538914 0.55661450 12 57751697 57751711 15 - 1.204 1.112 -0.327
ENSG00000135446 E027 19.3356548 0.0084190579 0.393020919 0.67798465 12 57751712 57751736 25 - 1.316 1.253 -0.218
ENSG00000135446 E028 0.3724725 0.0166961890 0.278146081   12 57751737 57751752 16 - 0.072 0.221 1.878
ENSG00000135446 E029 0.6088063 0.0243037877 0.833173097 0.93979625 12 57751753 57751877 125 - 0.188 0.221 0.293
ENSG00000135446 E030 1.2082353 0.0136954071 0.722651933 0.88859398 12 57751913 57752174 262 - 0.355 0.300 -0.345
ENSG00000135446 E031 29.6805960 0.0005109407 0.052816435 0.22843638 12 57752175 57752447 273 - 1.508 1.402 -0.367
ENSG00000135446 E032 0.0000000       12 57755932 57756013 82 -      

Help

Please Click HERE to learn more details about the results from DEXseq.