ENSG00000136280

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000258781 ENSG00000136280 No_inf pgKDN_inf CCM2 protein_coding protein_coding 40.0261 33.77021 42.59879 0.9087865 1.101641 0.3349729 24.545783 13.790446 30.453661 1.724260 1.398831 1.1423744 0.5983083 0.407575 0.715725 0.308150 0.001989437 0.001989437 FALSE TRUE
ENST00000381112 ENSG00000136280 No_inf pgKDN_inf CCM2 protein_coding protein_coding 40.0261 33.77021 42.59879 0.9087865 1.101641 0.3349729 5.811795 8.637210 4.572882 1.151841 1.501750 -0.9159797 0.1544000 0.255700 0.109825 -0.145875 0.224399525 0.001989437 FALSE TRUE
ENST00000541586 ENSG00000136280 No_inf pgKDN_inf CCM2 protein_coding protein_coding 40.0261 33.77021 42.59879 0.9087865 1.101641 0.3349729 4.301021 4.293018 4.080579 1.490246 2.419069 -0.0730439 0.1081250 0.128175 0.092800 -0.035375 0.771519160 0.001989437 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000136280 E001 0.6354303 0.0229777873 1.787882e-02 0.1178102028 7 44999475 44999818 344 + 0.000 0.356 12.078
ENSG00000136280 E002 0.8598093 0.4443473397 6.500848e-01 0.8526049827 7 44999819 44999857 39 + 0.232 0.305 0.531
ENSG00000136280 E003 0.0000000       7 45000188 45000188 1 +      
ENSG00000136280 E004 0.0000000       7 45000189 45000200 12 +      
ENSG00000136280 E005 2.9168687 0.0165706048 5.232523e-01 0.7766547987 7 45000201 45000248 48 + 0.633 0.550 -0.373
ENSG00000136280 E006 8.5349816 0.0329721087 5.986169e-01 0.8240431137 7 45000249 45000299 51 + 1.008 0.949 -0.219
ENSG00000136280 E007 12.8967145 0.0011561719 1.013780e-01 0.3324673374 7 45000300 45000363 64 + 1.200 1.077 -0.439
ENSG00000136280 E008 0.2539903 0.0161047749 2.224183e-01   7 45027015 45027025 11 + 0.000 0.179 12.857
ENSG00000136280 E009 0.4981306 0.0263099874 2.941216e-01   7 45027026 45027266 241 + 0.092 0.246 1.697
ENSG00000136280 E010 0.5073513 0.0162322722 3.906639e-02 0.1913720673 7 45027267 45027633 367 + 0.000 0.305 13.787
ENSG00000136280 E011 0.2536433 0.0160840826 2.224513e-01   7 45027634 45027671 38 + 0.000 0.179 12.857
ENSG00000136280 E012 0.3722815 0.0166637841 5.470992e-01   7 45027672 45027700 29 + 0.092 0.179 1.112
ENSG00000136280 E013 4.4747278 0.0056079448 1.265131e-02 0.0935716241 7 45027701 45027797 97 + 0.555 0.867 1.296
ENSG00000136280 E014 0.0000000       7 45029444 45029509 66 +      
ENSG00000136280 E015 9.5119796 0.0230949148 3.617435e-01 0.6511052328 7 45038253 45038260 8 + 1.064 0.973 -0.336
ENSG00000136280 E016 34.3830717 0.0004709146 9.295386e-02 0.3167153263 7 45038261 45038426 166 + 1.585 1.509 -0.258
ENSG00000136280 E017 0.2536433 0.0160840826 2.224513e-01   7 45063093 45063215 123 + 0.000 0.179 12.857
ENSG00000136280 E018 30.4926691 0.0005321311 1.469665e-01 0.4080351178 7 45063918 45064001 84 + 1.531 1.462 -0.236
ENSG00000136280 E019 37.1717340 0.0089688191 1.281087e-01 0.3793881858 7 45064463 45064602 140 + 1.620 1.539 -0.278
ENSG00000136280 E020 15.9421376 0.0009385217 9.380183e-02 0.3185033941 7 45064603 45064646 44 + 1.282 1.169 -0.400
ENSG00000136280 E021 4.8419415 0.0031141057 9.476396e-03 0.0776747648 7 45067636 45068442 807 + 0.583 0.896 1.282
ENSG00000136280 E022 19.8805018 0.0007239759 2.646828e-01 0.5577935853 7 45068443 45068493 51 + 1.351 1.286 -0.226
ENSG00000136280 E023 29.0624988 0.0093921688 4.142856e-01 0.6946193155 7 45068494 45068579 86 + 1.448 1.506 0.197
ENSG00000136280 E024 46.4577897 0.0043879908 9.261288e-01 0.9777979842 7 45069826 45069961 136 + 1.676 1.677 0.006
ENSG00000136280 E025 0.5074127 0.0158919760 3.914265e-02 0.1915629643 7 45069962 45070093 132 + 0.000 0.305 13.789
ENSG00000136280 E026 0.5070043 0.0161742784 3.907463e-02 0.1913950771 7 45070094 45070168 75 + 0.000 0.305 13.787
ENSG00000136280 E027 0.5067220 0.0785818199 4.532510e-02 0.2082074504 7 45070169 45070388 220 + 0.000 0.305 13.541
ENSG00000136280 E028 5.6094845 0.0025663377 7.767572e-04 0.0123398007 7 45070389 45071749 1361 + 0.583 0.973 1.571
ENSG00000136280 E029 2.9630953 0.0048487244 1.729018e-01 0.4458648892 7 45071750 45071872 123 + 0.494 0.683 0.849
ENSG00000136280 E030 4.0245342 0.0039665136 3.991489e-06 0.0001548755 7 45071873 45072337 465 + 0.288 0.910 2.919
ENSG00000136280 E031 3.7277727 0.0038342141 1.824960e-02 0.1192927544 7 45072338 45072725 388 + 0.494 0.802 1.334
ENSG00000136280 E032 27.5077413 0.0005237020 3.441390e-02 0.1771744474 7 45072726 45072783 58 + 1.506 1.397 -0.378
ENSG00000136280 E033 5.1457586 0.0982289698 3.283157e-04 0.0062562500 7 45072784 45073459 676 + 0.382 0.996 2.656
ENSG00000136280 E034 34.2641882 0.0036724289 1.118648e-01 0.3513014144 7 45073460 45073571 112 + 1.585 1.506 -0.270
ENSG00000136280 E035 6.8747745 0.0021040572 7.097496e-06 0.0002543497 7 45073572 45074269 698 + 0.583 1.077 1.953
ENSG00000136280 E036 39.2429215 0.0003959186 7.582140e-01 0.9051041796 7 45074270 45074408 139 + 1.608 1.601 -0.023
ENSG00000136280 E037 107.1037883 0.0002047919 6.756339e-01 0.8656553892 7 45075777 45076469 693 + 2.024 2.043 0.063

Help

Please Click HERE to learn more details about the results from DEXseq.