ENSG00000137462

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000260010 ENSG00000137462 No_inf pgKDN_inf TLR2 protein_coding protein_coding 65.56259 38.81518 83.14962 0.9222109 1.313268 1.09889 6.464802 8.560862 4.863951 0.3008633 0.2218265 -0.8143484 0.11984167 0.220525 0.058475 -0.162050 4.582213e-05 4.582213e-05 FALSE TRUE
ENST00000642580 ENSG00000137462 No_inf pgKDN_inf TLR2 protein_coding protein_coding 65.56259 38.81518 83.14962 0.9222109 1.313268 1.09889 15.512041 7.254644 23.875559 1.3477563 6.4180697 1.7171746 0.22771667 0.187925 0.288775 0.100850 7.331428e-01 4.582213e-05 FALSE TRUE
ENST00000642700 ENSG00000137462 No_inf pgKDN_inf TLR2 protein_coding protein_coding 65.56259 38.81518 83.14962 0.9222109 1.313268 1.09889 33.893049 19.096879 41.225499 1.5754891 6.6404505 1.1097947 0.51332500 0.492400 0.493975 0.001575 1.000000e+00 4.582213e-05 FALSE TRUE
ENST00000646900 ENSG00000137462 No_inf pgKDN_inf TLR2 protein_coding protein_coding 65.56259 38.81518 83.14962 0.9222109 1.313268 1.09889 6.250897 1.965401 9.509243 0.8178482 1.4489733 2.2687010 0.08714167 0.049750 0.114600 0.064850 4.879158e-01 4.582213e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000137462 E001 0.0000000       4 153683963 153684069 107 +      
ENSG00000137462 E002 0.3716209 1.651695e-02 2.994108e-01   4 153684070 153684260 191 + 0.074 0.216 1.794
ENSG00000137462 E003 0.6072630 1.475421e-02 8.763496e-01 9.580621e-01 4 153684261 153684264 4 + 0.192 0.216 0.209
ENSG00000137462 E004 1.6910338 8.651397e-03 5.299409e-01 7.812177e-01 4 153684265 153684279 15 + 0.456 0.360 -0.528
ENSG00000137462 E005 2.2983619 6.315966e-03 6.496072e-01 8.523771e-01 4 153684280 153684289 10 + 0.534 0.467 -0.321
ENSG00000137462 E006 7.3848343 6.771561e-02 7.624573e-01 9.073018e-01 4 153684290 153684360 71 + 0.926 0.890 -0.136
ENSG00000137462 E007 3.7947425 5.822878e-02 2.465471e-01 5.371550e-01 4 153687902 153687916 15 + 0.599 0.766 0.701
ENSG00000137462 E008 5.7218628 2.368707e-02 4.601622e-01 7.315879e-01 4 153687917 153687935 19 + 0.779 0.872 0.361
ENSG00000137462 E009 11.4623037 3.968893e-03 2.284383e-01 5.170852e-01 4 153687936 153687988 53 + 1.123 1.015 -0.392
ENSG00000137462 E010 12.7664784 1.260880e-03 7.308863e-02 2.746821e-01 4 153687989 153688047 59 + 1.180 1.028 -0.547
ENSG00000137462 E011 2.5418391 6.523700e-03 7.563107e-01 9.040127e-01 4 153688093 153688669 577 + 0.557 0.513 -0.206
ENSG00000137462 E012 26.8800834 5.003386e-04 2.429939e-18 5.748085e-16 4 153701500 153702226 727 + 1.169 1.673 1.745
ENSG00000137462 E013 16.0476214 8.584639e-04 1.048134e-08 7.438166e-07 4 153702227 153702510 284 + 1.013 1.428 1.472
ENSG00000137462 E014 13.3766627 1.017352e-03 1.141572e-09 9.605234e-08 4 153702511 153702891 381 + 0.896 1.378 1.735
ENSG00000137462 E015 12.8053445 2.449414e-02 5.648082e-01 8.039685e-01 4 153702892 153702907 16 + 1.152 1.089 -0.225
ENSG00000137462 E016 57.6217055 2.539146e-04 3.210430e-01 6.140553e-01 4 153702908 153703128 221 + 1.771 1.731 -0.133
ENSG00000137462 E017 625.6560345 7.688416e-05 1.383023e-03 1.922473e-02 4 153703129 153704850 1722 + 2.795 2.768 -0.090
ENSG00000137462 E018 337.1114524 1.154833e-04 2.268275e-01 5.150372e-01 4 153704851 153706326 1476 + 2.523 2.506 -0.057

Help

Please Click HERE to learn more details about the results from DEXseq.