ENSG00000137497

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000540626 ENSG00000137497 No_inf pgKDN_inf NUMA1 protein_coding retained_intron 34.54991 41.86904 32.05792 1.122718 1.658476 -0.3850976 5.705215 12.908112 1.2807104 0.6994614 1.2807104 -3.3231580 0.14797500 0.309725 0.035425 -0.274300 0.006395663 0.006395663 FALSE TRUE
ENST00000545721 ENSG00000137497 No_inf pgKDN_inf NUMA1 protein_coding nonsense_mediated_decay 34.54991 41.86904 32.05792 1.122718 1.658476 -0.3850976 3.529601 5.998230 1.8780696 0.3141972 0.3586469 -1.6700281 0.09800833 0.143275 0.059525 -0.083750 0.256040198 0.006395663 TRUE TRUE
ENST00000620566 ENSG00000137497 No_inf pgKDN_inf NUMA1 protein_coding protein_coding 34.54991 41.86904 32.05792 1.122718 1.658476 -0.3850976 4.645536 1.166837 8.6493134 1.1668365 0.7794363 2.8793387 0.14595000 0.029925 0.269300 0.239375 0.007421546 0.006395663 FALSE TRUE
MSTRG.5134.11 ENSG00000137497 No_inf pgKDN_inf NUMA1 protein_coding   34.54991 41.86904 32.05792 1.122718 1.658476 -0.3850976 10.658848 8.487144 13.2401021 1.4182284 0.1510709 0.6409535 0.32072500 0.200675 0.416975 0.216300 0.030653766 0.006395663 FALSE TRUE
MSTRG.5134.2 ENSG00000137497 No_inf pgKDN_inf NUMA1 protein_coding   34.54991 41.86904 32.05792 1.122718 1.658476 -0.3850976 3.010881 6.599779 0.5343543 2.4103369 0.3702610 -3.6019844 0.07848333 0.155100 0.016650 -0.138450 0.363661040 0.006395663 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000137497 E001 0.0000000       11 72002864 72002864 1 -      
ENSG00000137497 E002 0.0000000       11 72002865 72002871 7 -      
ENSG00000137497 E003 0.0000000       11 72002872 72003538 667 -      
ENSG00000137497 E004 48.0192129 0.0045607233 9.489644e-01 9.867620e-01 11 72003887 72004099 213 - 1.681 1.685 0.012
ENSG00000137497 E005 32.9221516 0.0058297769 4.431093e-01 7.182254e-01 11 72004225 72004341 117 - 1.549 1.504 -0.154
ENSG00000137497 E006 37.6002208 0.0006877170 2.857572e-01 5.793700e-01 11 72004640 72004816 177 - 1.608 1.558 -0.170
ENSG00000137497 E007 13.9919300 0.0032222724 3.973669e-01 6.814928e-01 11 72005233 72005242 10 - 1.206 1.141 -0.232
ENSG00000137497 E008 19.4019540 0.0019504253 4.358081e-01 7.122678e-01 11 72005243 72005285 43 - 1.332 1.281 -0.179
ENSG00000137497 E009 15.8413959 0.0009294086 4.490803e-01 7.229411e-01 11 72005286 72005369 84 - 1.250 1.197 -0.189
ENSG00000137497 E010 0.0000000       11 72006035 72006263 229 -      
ENSG00000137497 E011 18.9817165 0.0008135383 7.012603e-01 8.783159e-01 11 72007189 72007435 247 - 1.277 1.304 0.095
ENSG00000137497 E012 27.8334572 0.0005706636 1.448341e-15 2.569566e-13 11 72007436 72007925 490 - 1.083 1.597 1.795
ENSG00000137497 E013 7.5165036 0.0018470327 7.771331e-05 1.926190e-03 11 72007926 72008091 166 - 0.616 1.054 1.720
ENSG00000137497 E014 4.6590506 0.0031391238 2.637982e-05 7.780580e-04 11 72008092 72008145 54 - 0.330 0.900 2.609
ENSG00000137497 E015 12.0511489 0.0086086983 1.370635e-07 7.756958e-06 11 72008146 72008437 292 - 0.722 1.257 1.998
ENSG00000137497 E016 8.6881357 0.0375539035 5.523532e-06 2.050283e-04 11 72008438 72008687 250 - 0.515 1.141 2.495
ENSG00000137497 E017 27.6688297 0.0005130547 2.057084e-02 1.291930e-01 11 72008688 72008845 158 - 1.521 1.394 -0.435
ENSG00000137497 E018 8.5710254 0.0016401443 2.057459e-01 4.891214e-01 11 72008967 72008987 21 - 1.040 0.923 -0.435
ENSG00000137497 E019 27.0428798 0.0135284767 5.290401e-01 7.804870e-01 11 72008988 72009185 198 - 1.465 1.423 -0.146
ENSG00000137497 E020 21.5491317 0.0006630370 9.691690e-01 9.936412e-01 11 72009268 72009387 120 - 1.344 1.348 0.014
ENSG00000137497 E021 18.1388812 0.0007767995 4.631830e-01 7.332020e-01 11 72010786 72010854 69 - 1.243 1.295 0.183
ENSG00000137497 E022 0.3709916 0.0166456509 7.913913e-01   11 72012259 72012400 142 - 0.109 0.153 0.565
ENSG00000137497 E023 5.3618507 0.0028632360 2.270989e-02 1.371939e-01 11 72012401 72012442 42 - 0.616 0.889 1.105
ENSG00000137497 E024 106.2266121 0.0018705219 4.956973e-03 4.929008e-02 11 72012895 72014947 2053 - 2.071 1.987 -0.282
ENSG00000137497 E025 0.0000000       11 72014948 72015428 481 -      
ENSG00000137497 E026 0.0000000       11 72015429 72016260 832 -      
ENSG00000137497 E027 0.0000000       11 72016408 72016530 123 -      
ENSG00000137497 E028 1.2431366 0.0101838347 4.226938e-01 7.019496e-01 11 72016976 72017279 304 - 0.268 0.393 0.787
ENSG00000137497 E029 0.4897584 0.0158507093 7.622659e-01   11 72017280 72017686 407 - 0.196 0.153 -0.435
ENSG00000137497 E030 0.0000000       11 72017687 72017827 141 -      
ENSG00000137497 E031 0.1176306 0.0117342326 3.935334e-01   11 72018183 72018300 118 - 0.109 0.000 -13.009
ENSG00000137497 E032 7.7750498 0.0017796915 6.611176e-01 8.585572e-01 11 72018396 72018513 118 - 0.909 0.954 0.169
ENSG00000137497 E033 5.5716594 0.0027227499 3.523629e-01 6.424169e-01 11 72018823 72018902 80 - 0.745 0.852 0.423
ENSG00000137497 E034 0.0000000       11 72018903 72018961 59 -      
ENSG00000137497 E035 0.0000000       11 72018962 72018980 19 -      
ENSG00000137497 E036 2.2363145 0.1262150325 2.778253e-01 5.710889e-01 11 72019494 72019555 62 - 0.384 0.572 0.944
ENSG00000137497 E037 4.9012078 0.0426731851 6.227636e-01 8.375111e-01 11 72019556 72019598 43 - 0.807 0.734 -0.290
ENSG00000137497 E038 5.1382292 0.0031800486 3.304890e-01 6.229761e-01 11 72019599 72019600 2 - 0.844 0.734 -0.435
ENSG00000137497 E039 6.3536422 0.0241193224 2.305419e-01 5.190056e-01 11 72019601 72019617 17 - 0.939 0.797 -0.546
ENSG00000137497 E040 6.5542585 0.0280762294 1.939985e-02 1.245016e-01 11 72021204 72021225 22 - 1.017 0.734 -1.087
ENSG00000137497 E041 6.9179704 0.0021243204 4.343441e-03 4.493749e-02 11 72021226 72021291 66 - 1.040 0.751 -1.105
ENSG00000137497 E042 0.1187032 0.0119261012 3.933463e-01   11 72022202 72022338 137 - 0.109 0.000 -13.008
ENSG00000137497 E043 3.9085813 0.0036758966 2.294200e-01 5.180464e-01 11 72022339 72022382 44 - 0.766 0.619 -0.616
ENSG00000137497 E044 2.6969551 0.0069670504 4.810798e-01 7.462126e-01 11 72022383 72022419 37 - 0.616 0.521 -0.435
ENSG00000137497 E045 2.5853381 0.0152778705 9.673966e-01 9.934121e-01 11 72023065 72023081 17 - 0.552 0.547 -0.020
ENSG00000137497 E046 4.7968748 0.0031022820 8.846694e-01 9.611682e-01 11 72023082 72023107 26 - 0.766 0.751 -0.063
ENSG00000137497 E047 5.2697361 0.0026577831 4.020664e-01 6.851950e-01 11 72023108 72023129 22 - 0.844 0.751 -0.368
ENSG00000137497 E048 5.2582792 0.0027090632 2.543056e-01 5.460079e-01 11 72023130 72023137 8 - 0.861 0.734 -0.502
ENSG00000137497 E049 5.2667774 0.0028878827 4.030583e-01 6.861048e-01 11 72023138 72023147 10 - 0.844 0.751 -0.368
ENSG00000137497 E050 0.3813786 0.0360292405 1.805723e-01   11 72024071 72024273 203 - 0.000 0.213 13.097
ENSG00000137497 E051 5.5302086 0.0055718264 7.921565e-01 9.205811e-01 11 72024274 72024298 25 - 0.826 0.797 -0.113
ENSG00000137497 E052 3.7928763 0.0065639583 3.142805e-01 6.073876e-01 11 72024299 72024304 6 - 0.745 0.619 -0.528
ENSG00000137497 E053 3.3225346 0.0098906407 8.349525e-01 9.405711e-01 11 72024305 72024312 8 - 0.645 0.619 -0.113
ENSG00000137497 E054 5.0392280 0.0293509839 6.500726e-01 8.526050e-01 11 72024313 72024353 41 - 0.807 0.751 -0.224
ENSG00000137497 E055 0.1272623 0.0124159313 7.317836e-01   11 72024354 72024850 497 - 0.000 0.083 11.670
ENSG00000137497 E056 5.3218817 0.0209003192 5.338126e-01 7.841658e-01 11 72029205 72029290 86 - 0.745 0.825 0.319
ENSG00000137497 E057 4.1924377 0.0035583479 8.850652e-01 9.613160e-01 11 72035902 72035975 74 - 0.698 0.717 0.079
ENSG00000137497 E058 0.0000000       11 72035976 72035987 12 -      
ENSG00000137497 E059 0.0000000       11 72039735 72039825 91 -      
ENSG00000137497 E060 0.0000000       11 72040605 72040958 354 -      
ENSG00000137497 E061 0.0000000       11 72040959 72041137 179 -      
ENSG00000137497 E062 0.0000000       11 72041428 72041525 98 -      
ENSG00000137497 E063 0.0000000       11 72041722 72041822 101 -      
ENSG00000137497 E064 0.0000000       11 72041823 72042142 320 -      
ENSG00000137497 E065 0.8703145 0.1183667775 5.042771e-01 7.634749e-01 11 72049419 72049539 121 - 0.196 0.312 0.886
ENSG00000137497 E066 0.1265070 0.0123171844 7.318240e-01   11 72050662 72050833 172 - 0.000 0.083 11.671
ENSG00000137497 E067 0.1268540 0.0123365139 7.318515e-01   11 72062589 72062686 98 - 0.000 0.083 11.671
ENSG00000137497 E068 0.1271363 0.0123519106 7.318941e-01   11 72065199 72068078 2880 - 0.000 0.083 11.671
ENSG00000137497 E069 0.0000000       11 72068079 72068104 26 -      
ENSG00000137497 E070 0.6247610 0.0151095964 3.008965e-01 5.938868e-01 11 72068105 72068231 127 - 0.109 0.265 1.565
ENSG00000137497 E071 0.0000000       11 72068496 72068617 122 -      
ENSG00000137497 E072 3.0460048 0.0495591739 2.362370e-01 5.254188e-01 11 72069842 72069911 70 - 0.698 0.521 -0.783
ENSG00000137497 E073 1.9507248 0.0079518871 2.740817e-01 5.676355e-01 11 72069912 72070093 182 - 0.552 0.393 -0.798
ENSG00000137497 E074 0.0000000       11 72076568 72076757 190 -      
ENSG00000137497 E075 0.0000000       11 72080320 72080457 138 -      
ENSG00000137497 E076 0.0000000       11 72080458 72080693 236 -      

Help

Please Click HERE to learn more details about the results from DEXseq.