ENSG00000137845

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000260408 ENSG00000137845 No_inf pgKDN_inf ADAM10 protein_coding protein_coding 131.1772 146.0584 137.6816 5.051557 6.524278 -0.08520382 24.550821 34.260116 22.22196 0.04789013 0.2252227 -0.62431597 0.18516667 0.235400 0.162675 -0.072725 1.850617e-01 9.281059e-07 FALSE  
ENST00000396136 ENSG00000137845 No_inf pgKDN_inf ADAM10 protein_coding nonsense_mediated_decay 131.1772 146.0584 137.6816 5.051557 6.524278 -0.08520382 47.373375 48.462281 50.84830 2.60079045 0.9185825 0.06932321 0.36572500 0.332625 0.371750 0.039125 8.075180e-01 9.281059e-07 FALSE  
ENST00000402627 ENSG00000137845 No_inf pgKDN_inf ADAM10 protein_coding protein_coding 131.1772 146.0584 137.6816 5.051557 6.524278 -0.08520382 37.168074 44.308982 39.11963 2.50635759 3.9873628 -0.17966347 0.28203333 0.305025 0.282075 -0.022950 8.695059e-01 9.281059e-07 TRUE  
ENST00000462061 ENSG00000137845 No_inf pgKDN_inf ADAM10 protein_coding retained_intron 131.1772 146.0584 137.6816 5.051557 6.524278 -0.08520382 10.283569 11.053839 10.08446 4.83015077 2.9678384 -0.13228826 0.07532500 0.072575 0.071725 -0.000850 9.329377e-01 9.281059e-07 FALSE  
ENST00000558733 ENSG00000137845 No_inf pgKDN_inf ADAM10 protein_coding protein_coding_CDS_not_defined 131.1772 146.0584 137.6816 5.051557 6.524278 -0.08520382 8.131804 1.878273 13.88854 0.51219507 0.9178285 2.87979420 0.06394167 0.012825 0.101050 0.088225 9.281059e-07 9.281059e-07 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000137845 E001 1121.5706547 0.0000925695 2.321954e-29 1.318235e-26 15 58588809 58596871 8063 - 2.981 3.075 0.312
ENSG00000137845 E002 204.3551608 0.0001504359 6.806972e-01 8.681671e-01 15 58596872 58597163 292 - 2.297 2.306 0.033
ENSG00000137845 E003 51.7818461 0.0096240243 9.175441e-01 9.740666e-01 15 58597164 58597164 1 - 1.718 1.709 -0.030
ENSG00000137845 E004 74.6354393 0.0095239980 8.535380e-01 9.483216e-01 15 58597165 58597201 37 - 1.865 1.871 0.019
ENSG00000137845 E005 280.1389484 0.0004240988 8.967964e-01 9.659631e-01 15 58597202 58597518 317 - 2.437 2.440 0.011
ENSG00000137845 E006 119.7474497 0.0001573459 7.233733e-01 8.889136e-01 15 58597519 58597641 123 - 2.077 2.068 -0.030
ENSG00000137845 E007 115.8320466 0.0010804550 8.701595e-01 9.552531e-01 15 58599598 58599724 127 - 2.060 2.056 -0.013
ENSG00000137845 E008 2.6299279 0.4912202576 1.744595e-01 4.481802e-01 15 58609158 58610296 1139 - 0.337 0.651 1.568
ENSG00000137845 E009 156.3867509 0.0001154126 3.042059e-01 5.976417e-01 15 58610297 58610517 221 - 2.201 2.177 -0.081
ENSG00000137845 E010 6.3123268 0.0082165998 3.533718e-07 1.820320e-05 15 58610518 58610926 409 - 0.337 1.018 3.008
ENSG00000137845 E011 2.9866006 0.0069189605 2.333072e-01 5.221241e-01 15 58610927 58610998 72 - 0.484 0.651 0.765
ENSG00000137845 E012 105.2379290 0.0045039842 4.064881e-01 6.891374e-01 15 58610999 58611107 109 - 2.035 2.004 -0.105
ENSG00000137845 E013 1.3795885 0.0093128558 1.069314e-01 3.426557e-01 15 58611108 58611275 168 - 0.200 0.454 1.654
ENSG00000137845 E014 5.0431973 0.0027684593 1.425306e-05 4.636457e-04 15 58611276 58611807 532 - 0.337 0.923 2.654
ENSG00000137845 E015 69.0428483 0.0032591486 4.033994e-01 6.864039e-01 15 58611808 58611853 46 - 1.856 1.822 -0.117
ENSG00000137845 E016 106.3159340 0.0047000547 4.029980e-01 6.860456e-01 15 58611854 58611991 138 - 2.041 2.007 -0.112
ENSG00000137845 E017 117.6751888 0.0001417719 3.259854e-02 1.711239e-01 15 58621471 58621621 151 - 2.099 2.040 -0.198
ENSG00000137845 E018 41.6764943 0.0003349021 1.368498e-01 3.937662e-01 15 58627700 58627711 12 - 1.661 1.592 -0.234
ENSG00000137845 E019 118.2016808 0.0001661365 4.273132e-04 7.718255e-03 15 58627712 58627883 172 - 2.123 2.025 -0.326
ENSG00000137845 E020 0.0000000       15 58629264 58629464 201 -      
ENSG00000137845 E021 79.6348834 0.0008422419 7.309886e-02 2.747013e-01 15 58633196 58633314 119 - 1.934 1.871 -0.212
ENSG00000137845 E022 47.9160708 0.0013969439 8.363591e-01 9.413297e-01 15 58633315 58633359 45 - 1.685 1.676 -0.029
ENSG00000137845 E023 55.1654285 0.0003494034 5.373071e-02 2.307030e-01 15 58640777 58640830 54 - 1.785 1.707 -0.264
ENSG00000137845 E024 72.7339647 0.0002049043 2.735206e-02 1.539560e-01 15 58640831 58640960 130 - 1.903 1.826 -0.261
ENSG00000137845 E025 49.6932603 0.0012817458 1.844014e-01 4.615722e-01 15 58643886 58643978 93 - 1.730 1.671 -0.200
ENSG00000137845 E026 62.8444696 0.0002236173 1.310192e-01 3.839804e-01 15 58646055 58646204 150 - 1.829 1.772 -0.192
ENSG00000137845 E027 2.4572209 0.0128355972 7.318504e-01 8.933865e-01 15 58655243 58655416 174 - 0.560 0.512 -0.226
ENSG00000137845 E028 30.8897076 0.0013805214 5.501045e-01 7.946602e-01 15 58665097 58665145 49 - 1.513 1.481 -0.111
ENSG00000137845 E029 17.9744861 0.0010400947 7.424852e-01 8.982570e-01 15 58665146 58665151 6 - 1.282 1.260 -0.077
ENSG00000137845 E030 27.2059565 0.0004749571 1.726808e-02 1.150082e-01 15 58665152 58665181 30 - 1.517 1.383 -0.463
ENSG00000137845 E031 24.6350877 0.0008977801 3.134993e-05 8.960399e-04 15 58665182 58665197 16 - 1.532 1.284 -0.860
ENSG00000137845 E032 0.3804973 0.0158237822 1.932847e-01   15 58676143 58676293 151 - 0.000 0.208 11.147
ENSG00000137845 E033 28.7087374 0.0080582250 1.312537e-03 1.847348e-02 15 58679124 58679158 35 - 1.578 1.368 -0.725
ENSG00000137845 E034 54.6349956 0.0004957651 2.888230e-04 5.631736e-03 15 58679159 58679282 124 - 1.819 1.671 -0.503
ENSG00000137845 E035 29.3595368 0.0015490355 9.972208e-04 1.497747e-02 15 58682196 58682251 56 - 1.575 1.390 -0.636
ENSG00000137845 E036 38.1860920 0.0107789055 6.761872e-03 6.163508e-02 15 58682252 58682314 63 - 1.680 1.507 -0.590
ENSG00000137845 E037 0.2536433 0.0160120646 3.921959e-01   15 58698280 58698404 125 - 0.000 0.149 10.560
ENSG00000137845 E038 0.1265070 0.0122987584 7.742416e-01   15 58707307 58707380 74 - 0.000 0.081 9.673
ENSG00000137845 E039 50.1843110 0.0002758909 9.485393e-05 2.278776e-03 15 58717577 58717727 151 - 1.791 1.627 -0.558
ENSG00000137845 E040 5.9874310 0.0023310084 2.075647e-02 1.298098e-01 15 58747345 58748794 1450 - 0.654 0.923 1.069
ENSG00000137845 E041 1.1249367 0.0109558134 2.361397e-01 5.254188e-01 15 58748795 58749036 242 - 0.200 0.386 1.292
ENSG00000137845 E042 33.0528649 0.0004201922 1.569347e-03 2.117617e-02 15 58749480 58749791 312 - 1.614 1.451 -0.558

Help

Please Click HERE to learn more details about the results from DEXseq.