ENSG00000140650

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000268261 ENSG00000140650 No_inf pgKDN_inf PMM2 protein_coding protein_coding 32.39778 29.28892 34.06916 4.659329 2.19955 0.2180424 17.077135 8.678290 21.0774774 0.1926446 0.6856284 1.2792424 0.53195000 0.327825 0.623550 0.295725 0.02612464 0.02612464 FALSE TRUE
ENST00000564919 ENSG00000140650 No_inf pgKDN_inf PMM2 protein_coding retained_intron 32.39778 29.28892 34.06916 4.659329 2.19955 0.2180424 5.298415 10.392920 2.9830766 3.6424015 1.8635115 -1.7972874 0.15106667 0.308100 0.079775 -0.228325 0.52084482 0.02612464   FALSE
ENST00000613908 ENSG00000140650 No_inf pgKDN_inf PMM2 protein_coding retained_intron 32.39778 29.28892 34.06916 4.659329 2.19955 0.2180424 2.044788 2.222715 1.7295714 1.0166908 1.0140397 -0.3600673 0.06221667 0.068975 0.050850 -0.018125 0.82830574 0.02612464   FALSE
ENST00000682008 ENSG00000140650 No_inf pgKDN_inf PMM2 protein_coding protein_coding 32.39778 29.28892 34.06916 4.659329 2.19955 0.2180424 1.321696 0.427925 2.3426490 0.3168697 0.4984533 2.4255305 0.03904167 0.011600 0.069825 0.058225 0.17296489 0.02612464 FALSE TRUE
ENST00000684347 ENSG00000140650 No_inf pgKDN_inf PMM2 protein_coding protein_coding_CDS_not_defined 32.39778 29.28892 34.06916 4.659329 2.19955 0.2180424 1.413236 2.376304 0.7829504 0.1339917 0.4684220 -1.5894751 0.04957500 0.092625 0.024850 -0.067775 0.37040762 0.02612464   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000140650 E001 0.0000000       16 8788823 8788839 17 +      
ENSG00000140650 E002 0.0000000       16 8788840 8789011 172 +      
ENSG00000140650 E003 0.0000000       16 8795210 8795662 453 +      
ENSG00000140650 E004 0.1170040 0.0116809447 1.000000e+00   16 8797716 8797809 94 + 0.075 0.000 -9.828
ENSG00000140650 E005 0.4804091 0.0157585480 6.278964e-01   16 8797810 8797820 11 + 0.195 0.120 -0.831
ENSG00000140650 E006 0.5991122 0.0143115077 4.169762e-01 0.696747689 16 8797821 8797827 7 + 0.244 0.120 -1.246
ENSG00000140650 E007 1.1982854 0.0103295923 2.381560e-01 0.527070502 16 8797828 8797836 9 + 0.399 0.214 -1.246
ENSG00000140650 E008 1.1982854 0.0103295923 2.381560e-01 0.527070502 16 8797837 8797837 1 + 0.399 0.214 -1.246
ENSG00000140650 E009 1.3247924 0.0095347100 4.828491e-01 0.747673321 16 8797838 8797838 1 + 0.399 0.291 -0.661
ENSG00000140650 E010 1.3247924 0.0095347100 4.828491e-01 0.747673321 16 8797839 8797841 3 + 0.399 0.291 -0.661
ENSG00000140650 E011 1.8237720 0.0076329225 8.360993e-01 0.941167919 16 8797842 8797849 8 + 0.431 0.463 0.169
ENSG00000140650 E012 2.5327083 0.0061783703 3.988642e-01 0.682693022 16 8797850 8797866 17 + 0.583 0.463 -0.568
ENSG00000140650 E013 5.3981138 0.0027234070 2.937217e-02 0.161040848 16 8797867 8797911 45 + 0.881 0.621 -1.054
ENSG00000140650 E014 5.6215450 0.0153398102 1.041446e-02 0.082456467 16 8797912 8797948 37 + 0.912 0.587 -1.324
ENSG00000140650 E015 14.5687545 0.0012959064 2.941613e-02 0.161147189 16 8801799 8801910 112 + 1.241 1.072 -0.602
ENSG00000140650 E016 0.0000000       16 8802081 8802145 65 +      
ENSG00000140650 E017 0.2346346 0.0156489796 4.769710e-01   16 8802146 8802260 115 + 0.139 0.000 -13.128
ENSG00000140650 E018 0.2346346 0.0156489796 4.769710e-01   16 8802261 8802289 29 + 0.139 0.000 -13.128
ENSG00000140650 E019 0.5889148 0.0149975684 7.550780e-02 0.280741585 16 8802290 8802389 100 + 0.288 0.000 -14.224
ENSG00000140650 E020 14.1510346 0.0017123586 3.582237e-01 0.647714754 16 8804767 8804843 77 + 1.196 1.127 -0.246
ENSG00000140650 E021 15.7497021 0.0008655643 6.320154e-01 0.842244744 16 8806316 8806407 92 + 1.226 1.194 -0.115
ENSG00000140650 E022 2.8209503 0.0053287003 1.528976e-01 0.417200160 16 8806408 8807034 627 + 0.488 0.683 0.879
ENSG00000140650 E023 11.7838713 0.0016521404 1.622608e-03 0.021726349 16 8807564 8811078 3515 + 0.977 1.236 0.934
ENSG00000140650 E024 14.3117478 0.0050291630 8.477073e-01 0.946013352 16 8811079 8811178 100 + 1.180 1.166 -0.049
ENSG00000140650 E025 8.1118709 0.0112154225 6.335642e-01 0.843282524 16 8811638 8811641 4 + 0.968 0.920 -0.182
ENSG00000140650 E026 13.6996715 0.0010975233 8.097897e-01 0.929822587 16 8811642 8811713 72 + 1.164 1.147 -0.059
ENSG00000140650 E027 9.1957394 0.0206765534 6.452289e-01 0.849832055 16 8812991 8813106 116 + 1.018 0.967 -0.189
ENSG00000140650 E028 0.1186381 0.0118413841 1.000000e+00   16 8813107 8813385 279 + 0.075 0.000 -12.242
ENSG00000140650 E029 0.0000000       16 8829193 8829258 66 +      
ENSG00000140650 E030 0.1268540 0.0123809402 3.126575e-01   16 8842207 8842379 173 + 0.000 0.120 12.479
ENSG00000140650 E031 48.5296988 0.0003367113 9.002443e-02 0.311641690 16 8847724 8848765 1042 + 1.709 1.643 -0.225
ENSG00000140650 E032 50.6670319 0.0003376583 5.616457e-01 0.801860837 16 8848766 8849338 573 + 1.710 1.690 -0.069
ENSG00000140650 E033 0.8358892 0.0136616861 1.829127e-01 0.459595340 16 8849339 8849368 30 + 0.329 0.120 -1.831
ENSG00000140650 E034 2.6890541 0.0244308325 2.518348e-01 0.543081056 16 8849369 8849655 287 + 0.488 0.653 0.754
ENSG00000140650 E035 1.3393937 0.2340447022 6.572321e-01 0.856614103 16 8849849 8849993 145 + 0.328 0.413 0.491
ENSG00000140650 E036 3.4389063 0.0042344397 8.412085e-02 0.299451366 16 8849994 8850932 939 + 0.538 0.761 0.960
ENSG00000140650 E037 0.5082629 0.2180697348 2.632742e-02 0.150338090 16 8850933 8851050 118 + 0.000 0.356 13.908
ENSG00000140650 E038 0.0000000       16 8853312 8853525 214 +      
ENSG00000140650 E039 0.0000000       16 8853526 8853636 111 +      
ENSG00000140650 E040 0.0000000       16 8854264 8854356 93 +      
ENSG00000140650 E041 0.0000000       16 8855034 8855217 184 +      
ENSG00000140650 E042 3.7356073 0.0046816021 7.366705e-05 0.001835456 16 8855218 8855990 773 + 0.399 0.903 2.213
ENSG00000140650 E043 2.4878500 0.0065723575 3.444093e-03 0.038298718 16 8855991 8856412 422 + 0.329 0.736 1.976
ENSG00000140650 E044 1.9847443 0.0069949203 1.179312e-02 0.089597182 16 8859813 8859946 134 + 0.288 0.653 1.891
ENSG00000140650 E045 1.1148939 0.2899873963 1.502129e-01 0.412704240 16 8859947 8860127 181 + 0.195 0.463 1.755
ENSG00000140650 E046 3.3591639 0.0083394736 6.532592e-04 0.010745009 16 8860128 8860536 409 + 0.399 0.848 2.002
ENSG00000140650 E047 3.6208707 0.0100670456 4.042162e-05 0.001110469 16 8862026 8862534 509 + 0.365 0.903 2.406

Help

Please Click HERE to learn more details about the results from DEXseq.