ENSG00000140968

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000268638 ENSG00000140968 No_inf pgKDN_inf IRF8 protein_coding protein_coding 11.57997 21.98748 5.70662 0.8656126 0.1953204 -1.944104 5.2620605 7.2611239 3.2378234 2.5789915 1.1387614 -1.1627052 0.55106667 0.320750 0.586850 0.266100 7.821909e-01 1.151864e-05 FALSE TRUE
ENST00000566369 ENSG00000140968 No_inf pgKDN_inf IRF8 protein_coding protein_coding 11.57997 21.98748 5.70662 0.8656126 0.1953204 -1.944104 2.4039432 6.5349720 0.0000000 0.7773684 0.0000000 -9.3542432 0.13262500 0.297150 0.000000 -0.297150 1.151864e-05 1.151864e-05 FALSE TRUE
ENST00000696884 ENSG00000140968 No_inf pgKDN_inf IRF8 protein_coding nonsense_mediated_decay 11.57997 21.98748 5.70662 0.8656126 0.1953204 -1.944104 0.5035319 0.5470257 0.9635702 0.3196637 0.9635702 0.8055412 0.06422500 0.025450 0.167225 0.141775 1.000000e+00 1.151864e-05 FALSE TRUE
ENST00000696890 ENSG00000140968 No_inf pgKDN_inf IRF8 protein_coding protein_coding_CDS_not_defined 11.57997 21.98748 5.70662 0.8656126 0.1953204 -1.944104 0.3434655 0.0000000 1.0303964 0.0000000 1.0303964 6.7009895 0.05521667 0.000000 0.165650 0.165650 6.861872e-01 1.151864e-05 FALSE TRUE
MSTRG.11671.9 ENSG00000140968 No_inf pgKDN_inf IRF8 protein_coding   11.57997 21.98748 5.70662 0.8656126 0.1953204 -1.944104 1.1381898 3.4145694 0.0000000 2.3661264 0.0000000 -8.4197788 0.05535833 0.166075 0.000000 -0.166075 7.954296e-01 1.151864e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000140968 E001 0.0000000       16 85899116 85899161 46 +      
ENSG00000140968 E002 0.0000000       16 85899162 85899162 1 +      
ENSG00000140968 E003 0.8697828 0.0131812985 0.664125682 0.86032258 16 85899163 85899172 10 + 0.285 0.216 -0.523
ENSG00000140968 E004 0.8697828 0.0131812985 0.664125682 0.86032258 16 85899173 85899174 2 + 0.285 0.216 -0.523
ENSG00000140968 E005 1.4778635 0.0086469884 0.120449139 0.36715108 16 85899175 85899187 13 + 0.521 0.280 -1.359
ENSG00000140968 E006 2.6024220 0.0059854453 0.216098163 0.50222081 16 85899188 85899223 36 + 0.628 0.448 -0.845
ENSG00000140968 E007 0.6351783 0.0246256427 0.330466751 0.62297519 16 85900928 85901246 319 + 0.000 0.216 12.839
ENSG00000140968 E008 0.0000000       16 85902052 85902069 18 +      
ENSG00000140968 E009 0.3813786 0.0379557746 0.741940647   16 85902314 85902339 26 + 0.000 0.142 12.181
ENSG00000140968 E010 0.0000000       16 85902689 85902814 126 +      
ENSG00000140968 E011 0.0000000       16 85902815 85902825 11 +      
ENSG00000140968 E012 0.0000000       16 85902826 85902867 42 +      
ENSG00000140968 E013 0.0000000       16 85902868 85902889 22 +      
ENSG00000140968 E014 0.1271363 0.0123901987 1.000000000   16 85902890 85902966 77 + 0.000 0.053 10.768
ENSG00000140968 E015 0.1271363 0.0123901987 1.000000000   16 85902967 85903014 48 + 0.000 0.053 10.768
ENSG00000140968 E016 3.4918427 0.0049235509 0.665788165 0.86099407 16 85903015 85903022 8 + 0.628 0.570 -0.260
ENSG00000140968 E017 6.8231302 0.0032955012 0.106959349 0.34270454 16 85903023 85903130 108 + 0.949 0.771 -0.684
ENSG00000140968 E018 6.2944064 0.0383179490 0.030366528 0.16397560 16 85903131 85903189 59 + 0.992 0.710 -1.092
ENSG00000140968 E019 0.1187032 0.0119475941 0.115496850   16 85903190 85903531 342 + 0.166 0.000 -14.099
ENSG00000140968 E020 0.3804973 0.0159006557 0.741340639   16 85908636 85908756 121 + 0.000 0.142 12.213
ENSG00000140968 E021 11.9505977 0.0011234939 0.191528589 0.47114722 16 85908990 85909173 184 + 1.116 1.002 -0.416
ENSG00000140968 E022 1.0161183 0.1252747951 0.153771082 0.41865167 16 85909174 85909483 310 + 0.000 0.308 13.299
ENSG00000140968 E023 0.1268540 0.0123836621 1.000000000   16 85909484 85909486 3 + 0.000 0.053 10.768
ENSG00000140968 E024 3.1642836 0.0070525955 0.012702316 0.09382628 16 85909487 85910354 868 + 0.166 0.613 2.740
ENSG00000140968 E025 3.6622243 0.0039175933 0.030306061 0.16384594 16 85910355 85911569 1215 + 0.285 0.652 1.910
ENSG00000140968 E026 7.4767931 0.0032350753 0.346959526 0.63757663 16 85911570 85911658 89 + 0.925 0.825 -0.385
ENSG00000140968 E027 3.1401775 0.0053035852 0.485052716 0.74887937 16 85911894 85912500 607 + 0.456 0.570 0.548
ENSG00000140968 E028 1.6317211 0.0084221595 0.574959638 0.80964543 16 85912501 85913130 630 + 0.285 0.384 0.615
ENSG00000140968 E029 4.8426084 0.0030172561 0.179896575 0.45519784 16 85913131 85913164 34 + 0.817 0.652 -0.675
ENSG00000140968 E030 7.8756881 0.0020675186 0.900216496 0.96758472 16 85913165 85913236 72 + 0.875 0.865 -0.037
ENSG00000140968 E031 0.3807797 0.0226816426 0.743659851   16 85913237 85913312 76 + 0.000 0.142 12.203
ENSG00000140968 E032 0.0000000       16 85913826 85913973 148 +      
ENSG00000140968 E033 0.0000000       16 85913974 85914042 69 +      
ENSG00000140968 E034 0.0000000       16 85914043 85914141 99 +      
ENSG00000140968 E035 0.0000000       16 85914142 85914171 30 +      
ENSG00000140968 E036 0.2537694 0.0161319605 1.000000000   16 85914172 85914472 301 + 0.000 0.100 11.688
ENSG00000140968 E037 6.7355854 0.0189530558 0.474138372 0.74091939 16 85914473 85914520 48 + 0.875 0.790 -0.330
ENSG00000140968 E038 16.4612443 0.0008884019 0.330171493 0.62268233 16 85918417 85918803 387 + 1.212 1.139 -0.260
ENSG00000140968 E039 0.0000000       16 85918804 85918807 4 +      
ENSG00000140968 E040 10.4704017 0.0016670392 0.446318934 0.72071154 16 85920109 85920224 116 + 1.031 0.961 -0.260
ENSG00000140968 E041 106.9890922 0.0002544129 0.002071028 0.02623269 16 85921106 85922606 1501 + 1.871 1.959 0.294

Help

Please Click HERE to learn more details about the results from DEXseq.