ENSG00000142192

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000346798 ENSG00000142192 No_inf pgKDN_inf APP protein_coding protein_coding 123.5193 74.73131 133.2895 1.452928 2.097921 0.8346931 31.93480 21.283972 34.799229 1.494732 2.394438 0.7090248 0.26350833 0.285075 0.26115 -0.023925 0.864231317 0.005984994 FALSE TRUE
ENST00000354192 ENSG00000142192 No_inf pgKDN_inf APP protein_coding protein_coding 123.5193 74.73131 133.2895 1.452928 2.097921 0.8346931 5.91915 6.176347 5.693775 4.386002 2.273449 -0.1171707 0.05328333 0.081325 0.04200 -0.039325 0.863088374 0.005984994 FALSE TRUE
ENST00000357903 ENSG00000142192 No_inf pgKDN_inf APP protein_coding protein_coding 123.5193 74.73131 133.2895 1.452928 2.097921 0.8346931 71.65797 30.689648 78.485451 0.483528 3.417377 1.3543869 0.55047500 0.411125 0.58920 0.178075 0.005984994 0.005984994 FALSE TRUE
MSTRG.18678.5 ENSG00000142192 No_inf pgKDN_inf APP protein_coding   123.5193 74.73131 133.2895 1.452928 2.097921 0.8346931 10.52868 14.298930 12.019703 2.174165 1.323681 -0.2503147 0.10513333 0.192475 0.09040 -0.102075 0.153536683 0.005984994 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000142192 E001 0.2459004 1.658612e-02 0.7171976752   21 25880550 25880550 1 - 0.077 0.117 0.676
ENSG00000142192 E002 409.1142902 2.300089e-04 0.0001928394 0.004062734 21 25880551 25881330 780 - 2.581 2.638 0.190
ENSG00000142192 E003 65.4245826 2.176138e-04 0.0345782808 0.177686661 21 25881331 25881331 1 - 1.780 1.860 0.271
ENSG00000142192 E004 225.9675049 1.290630e-03 0.1973669556 0.478632616 21 25881332 25881513 182 - 2.335 2.366 0.106
ENSG00000142192 E005 147.0694940 9.572026e-04 0.7689868172 0.910627621 21 25881514 25881609 96 - 2.159 2.167 0.030
ENSG00000142192 E006 170.9042700 9.775034e-05 0.7947787721 0.921880474 21 25881610 25881771 162 - 2.224 2.231 0.024
ENSG00000142192 E007 162.6285351 1.212173e-04 0.8706248762 0.955410896 21 25891722 25891868 147 - 2.203 2.208 0.016
ENSG00000142192 E008 115.8455431 1.442093e-04 0.9844557371 0.998792468 21 25897573 25897673 101 - 2.059 2.060 0.005
ENSG00000142192 E009 0.8428717 1.459031e-01 0.6184490715 0.834957666 21 25897674 25897983 310 - 0.294 0.209 -0.645
ENSG00000142192 E010 55.6357722 3.039741e-04 0.8138127252 0.931893323 21 25905024 25905077 54 - 1.741 1.751 0.036
ENSG00000142192 E011 149.0943346 2.518610e-03 0.7386464821 0.896401233 21 25911741 25911962 222 - 2.163 2.175 0.038
ENSG00000142192 E012 0.7435278 1.379004e-02 0.1682733917 0.439417637 21 25945524 25945975 452 - 0.142 0.350 1.676
ENSG00000142192 E013 94.6868203 4.485776e-03 0.6672598733 0.861528839 21 25954590 25954689 100 - 1.965 1.984 0.064
ENSG00000142192 E014 109.7501576 1.573616e-04 0.2755548356 0.569154967 21 25955627 25955755 129 - 2.048 2.017 -0.104
ENSG00000142192 E015 89.6525079 1.680117e-04 0.0646209945 0.256232077 21 25975070 25975189 120 - 1.972 1.913 -0.200
ENSG00000142192 E016 45.4136435 3.305449e-04 0.1502135512 0.412704240 21 25975190 25975228 39 - 1.683 1.618 -0.221
ENSG00000142192 E017 57.0700990 1.255167e-03 0.8422905754 0.943431216 21 25975954 25976028 75 - 1.759 1.751 -0.025
ENSG00000142192 E018 92.1083590 2.237945e-04 0.0124850260 0.092750330 21 25982344 25982477 134 - 1.991 1.911 -0.270
ENSG00000142192 E019 0.4910497 9.545059e-02 0.6507495123   21 25997188 25997359 172 - 0.142 0.209 0.676
ENSG00000142192 E020 17.9827826 7.258929e-04 0.8733997349 0.956854384 21 25997360 25997416 57 - 1.265 1.278 0.042
ENSG00000142192 E021 113.7937106 2.305082e-04 0.0808372375 0.292198638 21 26000015 26000182 168 - 2.071 2.021 -0.167
ENSG00000142192 E022 0.2362687 1.573037e-02 0.4483579421   21 26009596 26009913 318 - 0.142 0.000 -11.411
ENSG00000142192 E023 72.3437348 3.127186e-04 0.6909883371 0.873200729 21 26021840 26021921 82 - 1.862 1.849 -0.045
ENSG00000142192 E024 98.1145475 1.626189e-04 0.3871417412 0.673030643 21 26021922 26022042 121 - 1.976 2.004 0.093
ENSG00000142192 E025 72.8332500 2.064241e-04 0.7190250805 0.886807486 21 26051000 26051159 160 - 1.865 1.853 -0.040
ENSG00000142192 E026 26.9229182 7.329072e-04 0.5316157899 0.782195712 21 26051160 26051193 34 - 1.452 1.416 -0.123
ENSG00000142192 E027 46.6288770 3.404398e-04 0.1605895033 0.428477010 21 26053236 26053348 113 - 1.694 1.631 -0.213
ENSG00000142192 E028 0.0000000       21 26053349 26053502 154 -      
ENSG00000142192 E029 0.2441403 1.642377e-02 0.7167863044   21 26068125 26068338 214 - 0.077 0.117 0.676
ENSG00000142192 E030 0.2372762 3.009072e-01 0.5242508852   21 26089511 26089942 432 - 0.142 0.000 -9.973
ENSG00000142192 E031 55.9646570 2.259375e-03 0.1912418652 0.470683356 21 26089943 26090072 130 - 1.770 1.711 -0.199
ENSG00000142192 E032 24.2900851 1.537398e-03 0.0549475477 0.233459984 21 26111979 26111984 6 - 1.440 1.318 -0.422
ENSG00000142192 E033 59.9781614 5.644538e-04 0.2095229790 0.493920729 21 26111985 26112146 162 - 1.796 1.746 -0.169
ENSG00000142192 E034 0.0000000       21 26140153 26140460 308 -      
ENSG00000142192 E035 0.0000000       21 26169218 26169429 212 -      
ENSG00000142192 E036 49.5900796 5.342798e-03 0.1111487145 0.350034729 21 26170564 26170812 249 - 1.728 1.644 -0.287
ENSG00000142192 E037 0.0000000       21 26170985 26171128 144 -      

Help

Please Click HERE to learn more details about the results from DEXseq.