ENSG00000143457

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000271732 ENSG00000143457 No_inf pgKDN_inf GOLPH3L protein_coding protein_coding 11.01102 14.63688 10.24667 0.8478506 0.1462642 -0.514031 7.5496330 6.690158 9.1155455 0.7639323 0.6898723 0.4457158 0.73325833 0.471950 0.88955 0.417600 0.05945537 0.02919642 FALSE TRUE
ENST00000479757 ENSG00000143457 No_inf pgKDN_inf GOLPH3L protein_coding protein_coding_CDS_not_defined 11.01102 14.63688 10.24667 0.8478506 0.1462642 -0.514031 0.4344679 1.303404 0.0000000 0.5079836 0.0000000 -7.0371665 0.02809167 0.084275 0.00000 -0.084275 0.12139371 0.02919642   FALSE
MSTRG.1826.2 ENSG00000143457 No_inf pgKDN_inf GOLPH3L protein_coding   11.01102 14.63688 10.24667 0.8478506 0.1462642 -0.514031 2.3983409 6.519521 0.6755018 1.1766710 0.6755018 -3.2517447 0.16783333 0.435800 0.06770 -0.368100 0.02919642 0.02919642 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000143457 E001 0.1265070 0.0123089540 7.623923e-01   1 150646230 150646231 2 - 0.000 0.081 8.460
ENSG00000143457 E002 98.9819318 0.0002867157 1.796385e-09 1.456936e-07 1 150646232 150647783 1552 - 1.903 2.039 0.456
ENSG00000143457 E003 40.3137686 0.0004346024 1.657518e-01 4.356347e-01 1 150647784 150648436 653 - 1.642 1.582 -0.206
ENSG00000143457 E004 23.2394468 0.0043500204 2.260068e-03 2.802491e-02 1 150648437 150648748 312 - 1.480 1.290 -0.659
ENSG00000143457 E005 9.7815212 0.0014383596 4.307962e-02 2.024032e-01 1 150661814 150661928 115 - 1.122 0.945 -0.651
ENSG00000143457 E006 7.4596219 0.0019603520 1.360340e-01 3.921985e-01 1 150663632 150663763 132 - 1.002 0.855 -0.554
ENSG00000143457 E007 0.9894559 0.0129578685 8.241664e-01 9.361749e-01 1 150693458 150693527 70 - 0.273 0.307 0.231
ENSG00000143457 E008 0.4892854 0.0158772331 7.296207e-01   1 150694108 150694173 66 - 0.200 0.149 -0.506
ENSG00000143457 E009 0.4991354 0.0152892907 5.138921e-01   1 150694512 150694655 144 - 0.111 0.208 1.079
ENSG00000143457 E010 11.3624335 0.0015354865 1.505117e-02 1.053153e-01 1 150694656 150694850 195 - 1.193 0.993 -0.724
ENSG00000143457 E011 0.1272623 0.0124827618 7.622103e-01   1 150695730 150695747 18 - 0.000 0.081 10.160
ENSG00000143457 E012 3.0637314 0.1555004097 5.113490e-01 7.685426e-01 1 150696992 150697154 163 - 0.681 0.540 -0.623

Help

Please Click HERE to learn more details about the results from DEXseq.