ENSG00000144566

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000273047 ENSG00000144566 No_inf pgKDN_inf RAB5A protein_coding protein_coding 39.2088 37.74685 44.87845 1.426481 2.166974 0.2496057 18.7104468 11.546452 25.07183 0.5224538 1.649916 1.1179439 0.47582500 0.308175 0.560850 0.252675 0.01029365 0.01029365 FALSE TRUE
ENST00000412966 ENSG00000144566 No_inf pgKDN_inf RAB5A protein_coding nonsense_mediated_decay 39.2088 37.74685 44.87845 1.426481 2.166974 0.2496057 0.9311851 2.793555 0.00000 1.6876167 0.000000 -8.1311138 0.02455000 0.073650 0.000000 -0.073650 0.46553620 0.01029365 TRUE FALSE
ENST00000422242 ENSG00000144566 No_inf pgKDN_inf RAB5A protein_coding protein_coding 39.2088 37.74685 44.87845 1.426481 2.166974 0.2496057 2.5772265 0.000000 0.00000 0.0000000 0.000000 0.0000000 0.07389167 0.000000 0.000000 0.000000   0.01029365 FALSE TRUE
ENST00000473608 ENSG00000144566 No_inf pgKDN_inf RAB5A protein_coding retained_intron 39.2088 37.74685 44.87845 1.426481 2.166974 0.2496057 13.9703204 20.758343 16.44755 0.2459934 2.007377 -0.3356367 0.35060000 0.552000 0.367625 -0.184375 0.14606261 0.01029365 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000144566 E001 1.7870168 0.0088113192 1.081832e-02 0.0846390867 3 19947097 19947249 153 + 0.583 0.190 -2.364
ENSG00000144566 E002 7.2615123 0.0019826540 8.698928e-02 0.3056258263 3 19947250 19947378 129 + 0.987 0.813 -0.664
ENSG00000144566 E003 6.3201086 0.0026121394 4.036430e-01 0.6865380536 3 19947379 19947398 20 + 0.902 0.813 -0.343
ENSG00000144566 E004 6.0547901 0.0023413357 1.431691e-01 0.4029474347 3 19947399 19947404 6 + 0.913 0.754 -0.621
ENSG00000144566 E005 5.7915151 0.0024881548 3.320649e-02 0.1732068762 3 19947405 19947409 5 + 0.925 0.686 -0.945
ENSG00000144566 E006 14.6358380 0.0011003990 1.200214e-02 0.0905347701 3 19947410 19947521 112 + 1.271 1.079 -0.682
ENSG00000144566 E007 0.0000000       3 19947522 19947863 342 +      
ENSG00000144566 E008 32.3307008 0.0004549662 1.084348e-01 0.3454006308 3 19950806 19951000 195 + 1.557 1.475 -0.281
ENSG00000144566 E009 19.2928826 0.0007443849 6.636927e-02 0.2595012317 3 19951001 19951061 61 + 1.358 1.236 -0.426
ENSG00000144566 E010 0.8543273 0.4864465048 8.801583e-01 0.9595807428 3 19951062 19951225 164 + 0.272 0.261 -0.080
ENSG00000144566 E011 0.8622586 0.0151111853 4.991043e-01 0.7593853048 3 19970548 19970717 170 + 0.218 0.322 0.751
ENSG00000144566 E012 0.7434664 0.1259603532 3.241306e-01 0.6166259821 3 19975516 19975586 71 + 0.157 0.322 1.336
ENSG00000144566 E013 0.8801057 0.0130804114 2.425861e-02 0.1427565766 3 19975587 19975600 14 + 0.086 0.423 2.919
ENSG00000144566 E014 18.0647628 0.0008567082 9.287992e-01 0.9789545544 3 19975601 19975642 42 + 1.276 1.282 0.022
ENSG00000144566 E015 30.8717079 0.0004590283 7.875599e-01 0.9185445799 3 19975643 19975752 110 + 1.495 1.510 0.050
ENSG00000144566 E016 33.4351406 0.0004302343 1.459740e-01 0.4068714304 3 19976047 19976169 123 + 1.568 1.495 -0.249
ENSG00000144566 E017 28.0281713 0.0004844208 7.109055e-01 0.8831190413 3 19978310 19978403 94 + 1.470 1.451 -0.068
ENSG00000144566 E018 2.3693918 0.0087736430 1.051045e-02 0.0829850276 3 19978404 19978891 488 + 0.320 0.686 1.821
ENSG00000144566 E019 246.1884343 0.0001074943 2.088994e-05 0.0006395231 3 19983708 19985175 1468 + 2.365 2.421 0.189

Help

Please Click HERE to learn more details about the results from DEXseq.