ENSG00000149948

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000403681 ENSG00000149948 No_inf pgKDN_inf HMGA2 protein_coding protein_coding 23.50236 15.52107 29.43999 0.2773257 0.8472525 0.9231097 7.8577488 2.052134 10.7987952 0.3710036 1.1201657 2.3899956 0.30825833 0.132925 0.367075 0.234150 0.03176321 0.03176321 FALSE FALSE
ENST00000537275 ENSG00000149948 No_inf pgKDN_inf HMGA2 protein_coding nonsense_mediated_decay 23.50236 15.52107 29.43999 0.2773257 0.8472525 0.9231097 0.7774389 1.101123 0.4878662 0.3742893 0.3156757 -1.1581880 0.03794167 0.070050 0.016275 -0.053775 0.54185321 0.03176321 TRUE FALSE
ENST00000539662 ENSG00000149948 No_inf pgKDN_inf HMGA2 protein_coding nonsense_mediated_decay 23.50236 15.52107 29.43999 0.2773257 0.8472525 0.9231097 12.7279809 10.164226 15.6748316 0.3550775 0.9182530 0.6244509 0.55567500 0.655425 0.533175 -0.122250 0.52730250 0.03176321   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000149948 E001 0.2451451 0.0164052361 6.414812e-01   12 65824460 65824482 23 + 0.072 0.124 0.868
ENSG00000149948 E002 3.6052457 0.0106731988 1.620086e-01 4.303473e-01 12 65824483 65824810 328 + 0.713 0.521 -0.847
ENSG00000149948 E003 1.5789087 0.0083181280 8.250692e-01 9.366253e-01 12 65824811 65824897 87 + 0.389 0.424 0.191
ENSG00000149948 E004 6.9980287 0.0027203040 4.783186e-01 7.443272e-01 12 65824898 65825122 225 + 0.916 0.842 -0.283
ENSG00000149948 E005 20.9901600 0.0006815789 1.127514e-01 3.532463e-01 12 65825123 65825381 259 + 1.363 1.260 -0.361
ENSG00000149948 E006 14.4053790 0.0012185575 8.151112e-01 9.323955e-01 12 65828001 65828087 87 + 1.180 1.163 -0.059
ENSG00000149948 E007 1.9795445 0.0076411518 3.020179e-02 1.634781e-01 12 65828088 65829013 926 + 0.319 0.634 1.606
ENSG00000149948 E008 10.2956250 0.0014003167 9.713499e-01 9.945061e-01 12 65838519 65838569 51 + 1.040 1.038 -0.005
ENSG00000149948 E009 0.9895209 0.0119007219 1.246912e-01 3.743683e-01 12 65842134 65842254 121 + 0.188 0.424 1.606
ENSG00000149948 E010 7.5670980 0.0018361372 5.329805e-07 2.632397e-05 12 65842591 65843523 933 + 0.665 1.163 1.905
ENSG00000149948 E011 1.4963689 0.0093773392 5.807141e-03 5.513555e-02 12 65867489 65867807 319 + 0.188 0.600 2.454
ENSG00000149948 E012 0.0000000       12 65881743 65881890 148 +      
ENSG00000149948 E013 0.0000000       12 65881891 65882126 236 +      
ENSG00000149948 E014 0.8553059 0.0171251308 6.921496e-01 8.740235e-01 12 65914720 65915058 339 + 0.237 0.299 0.454
ENSG00000149948 E015 2.1794278 0.2122260365 9.363934e-01 9.818623e-01 12 65915059 65915527 469 + 0.502 0.475 -0.131
ENSG00000149948 E016 6.6495881 0.0119930432 9.051760e-01 9.696144e-01 12 65951383 65951415 33 + 0.876 0.862 -0.052
ENSG00000149948 E017 1.2240931 0.0129350608 3.544793e-01 6.442246e-01 12 65951416 65952355 940 + 0.280 0.424 0.869
ENSG00000149948 E018 9.8206739 0.0171605237 3.474706e-03 3.855272e-02 12 65952356 65958854 6499 + 0.886 1.183 1.087
ENSG00000149948 E019 305.5274830 0.0001284052 1.107233e-02 8.593807e-02 12 65963245 65966291 3047 + 2.479 2.459 -0.068

Help

Please Click HERE to learn more details about the results from DEXseq.