ENSG00000151062

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000536846 ENSG00000151062 No_inf pgKDN_inf CACNA2D4 protein_coding protein_coding 46.06172 62.76675 40.32227 2.320213 1.357809 -0.6382959 0.8229149 0.000000 2.468745 0.0000000 2.4687446 7.953465830 0.02176667 0.000000 0.065300 0.065300 8.259883e-01 6.671307e-05 FALSE TRUE
ENST00000537923 ENSG00000151062 No_inf pgKDN_inf CACNA2D4 protein_coding nonsense_mediated_decay 46.06172 62.76675 40.32227 2.320213 1.357809 -0.6382959 0.8555837 0.000000 2.566751 0.0000000 2.5667511 8.009409369 0.02172500 0.000000 0.065175 0.065175 8.249640e-01 6.671307e-05 FALSE FALSE
ENST00000538027 ENSG00000151062 No_inf pgKDN_inf CACNA2D4 protein_coding protein_coding 46.06172 62.76675 40.32227 2.320213 1.357809 -0.6382959 4.8804217 6.360460 2.178322 3.6726311 2.1783224 -1.541572249 0.11559167 0.105175 0.055325 -0.049850 8.616254e-01 6.671307e-05 FALSE TRUE
ENST00000542340 ENSG00000151062 No_inf pgKDN_inf CACNA2D4 protein_coding retained_intron 46.06172 62.76675 40.32227 2.320213 1.357809 -0.6382959 3.5981499 3.817064 3.812193 2.2111618 2.3010211 -0.001837523 0.08030000 0.058925 0.092025 0.033100 9.864361e-01 6.671307e-05 FALSE FALSE
ENST00000543405 ENSG00000151062 No_inf pgKDN_inf CACNA2D4 protein_coding retained_intron 46.06172 62.76675 40.32227 2.320213 1.357809 -0.6382959 7.7054820 7.573735 9.441408 0.5949606 1.2585976 0.317620754 0.17231667 0.121475 0.234575 0.113100 2.682777e-01 6.671307e-05 FALSE TRUE
ENST00000585385 ENSG00000151062 No_inf pgKDN_inf CACNA2D4 protein_coding nonsense_mediated_decay 46.06172 62.76675 40.32227 2.320213 1.357809 -0.6382959 3.5959305 0.000000 7.419876 0.0000000 3.2736007 9.537194283 0.09073333 0.000000 0.179525 0.179525 6.682597e-03 6.671307e-05 FALSE TRUE
ENST00000588896 ENSG00000151062 No_inf pgKDN_inf CACNA2D4 protein_coding retained_intron 46.06172 62.76675 40.32227 2.320213 1.357809 -0.6382959 2.6158528 5.863843 0.000000 2.0027381 0.0000000 -9.198160782 0.04830000 0.091525 0.000000 -0.091525 6.671307e-05 6.671307e-05   FALSE
MSTRG.5818.1 ENSG00000151062 No_inf pgKDN_inf CACNA2D4 protein_coding   46.06172 62.76675 40.32227 2.320213 1.357809 -0.6382959 6.7024409 9.634800 5.321135 1.3679453 0.5318648 -0.855308637 0.14345833 0.151875 0.132575 -0.019300 8.914166e-01 6.671307e-05 FALSE TRUE
MSTRG.5818.20 ENSG00000151062 No_inf pgKDN_inf CACNA2D4 protein_coding   46.06172 62.76675 40.32227 2.320213 1.357809 -0.6382959 3.6860987 5.190880 1.509264 1.2581959 1.0286920 -1.775383214 0.08015000 0.082950 0.038775 -0.044175 5.260328e-01 6.671307e-05 FALSE TRUE
MSTRG.5818.6 ENSG00000151062 No_inf pgKDN_inf CACNA2D4 protein_coding   46.06172 62.76675 40.32227 2.320213 1.357809 -0.6382959 3.7080228 7.980663 1.376374 1.5157762 0.4744029 -2.526998611 0.07273333 0.127200 0.033625 -0.093575 9.955995e-02 6.671307e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000151062 E001 0.2536433 0.0160875346 1.000000e+00   12 1791962 1791962 1 - 0.000 0.114 10.216
ENSG00000151062 E002 2.9825079 0.0484645183 8.016851e-01 0.925993194 12 1791963 1792003 41 - 0.579 0.551 -0.127
ENSG00000151062 E003 78.8224992 0.0002135020 1.234248e-02 0.092033672 12 1792004 1792772 769 - 1.760 1.872 0.377
ENSG00000151062 E004 13.1732577 0.0014641083 2.178977e-02 0.133957528 12 1792773 1792801 29 - 0.912 1.149 0.866
ENSG00000151062 E005 28.1717748 0.0005048973 1.218120e-02 0.091386981 12 1792802 1793042 241 - 1.268 1.450 0.633
ENSG00000151062 E006 12.0374290 0.0011186925 3.914890e-02 0.191567470 12 1793043 1793168 126 - 0.891 1.110 0.809
ENSG00000151062 E007 40.8304631 0.0003356001 1.499421e-01 0.412453533 12 1793169 1793507 339 - 1.495 1.588 0.317
ENSG00000151062 E008 9.5824085 0.0434503414 7.118466e-01 0.883487764 12 1793508 1793522 15 - 0.990 0.967 -0.084
ENSG00000151062 E009 11.6801593 0.0330654333 4.377041e-01 0.713943971 12 1793523 1793565 43 - 1.099 1.032 -0.242
ENSG00000151062 E010 8.9369007 0.0147970813 3.521893e-01 0.642232594 12 1793566 1793602 37 - 1.007 0.923 -0.316
ENSG00000151062 E011 5.4724024 0.0250334253 6.928859e-01 0.874425668 12 1793603 1793613 11 - 0.791 0.753 -0.153
ENSG00000151062 E012 19.2256368 0.0007596522 3.504338e-01 0.640666390 12 1793614 1793759 146 - 1.186 1.273 0.306
ENSG00000151062 E013 0.6162956 0.0183196235 5.189766e-01 0.773773543 12 1795060 1795108 49 - 0.255 0.162 -0.822
ENSG00000151062 E014 0.7428026 0.0137570557 7.190766e-01 0.886807486 12 1795109 1795113 5 - 0.255 0.204 -0.407
ENSG00000151062 E015 1.2325001 0.0100891818 3.650374e-01 0.653476157 12 1795114 1795118 5 - 0.414 0.279 -0.822
ENSG00000151062 E016 2.8289396 0.0073353897 8.728876e-02 0.306260210 12 1795119 1795142 24 - 0.698 0.470 -1.028
ENSG00000151062 E017 13.9669629 0.0010042689 1.466054e-02 0.103427263 12 1795143 1795298 156 - 1.249 1.067 -0.649
ENSG00000151062 E018 18.2721181 0.0016370566 4.834309e-01 0.747986310 12 1795299 1795335 37 - 1.259 1.221 -0.133
ENSG00000151062 E019 20.9702638 0.0006705006 1.246925e-01 0.374368250 12 1795336 1795381 46 - 1.353 1.262 -0.316
ENSG00000151062 E020 4.4824005 0.0043032986 8.796048e-01 0.959365092 12 1795382 1795667 286 - 0.698 0.691 -0.028
ENSG00000151062 E021 13.2621717 0.0020852466 1.149833e-01 0.357413032 12 1795668 1795672 5 - 1.186 1.067 -0.427
ENSG00000151062 E022 36.9816014 0.0003766735 4.163036e-02 0.198329902 12 1795673 1795780 108 - 1.590 1.498 -0.311
ENSG00000151062 E023 1.0150463 0.0121394240 6.390796e-02 0.254621565 12 1795781 1795949 169 - 0.000 0.343 14.228
ENSG00000151062 E024 46.5825490 0.0003225131 8.138868e-04 0.012782810 12 1797418 1797535 118 - 1.719 1.581 -0.470
ENSG00000151062 E025 1.6942172 0.0121653561 3.861974e-03 0.041451081 12 1797536 1797660 125 - 0.662 0.243 -2.255
ENSG00000151062 E026 19.0246795 0.0007661257 5.579916e-01 0.799689583 12 1799675 1799675 1 - 1.268 1.240 -0.098
ENSG00000151062 E027 22.7857782 0.0006235373 9.696318e-01 0.993764751 12 1799676 1799688 13 - 1.312 1.325 0.044
ENSG00000151062 E028 18.8169785 0.0012440222 8.189253e-01 0.934039279 12 1799689 1799695 7 - 1.219 1.251 0.115
ENSG00000151062 E029 22.9054807 0.0006412304 2.688664e-02 0.152273844 12 1799696 1799999 304 - 1.186 1.364 0.623
ENSG00000151062 E030 16.0200591 0.0026698456 3.748630e-01 0.662549641 12 1800000 1800006 7 - 1.219 1.162 -0.200
ENSG00000151062 E031 19.3381309 0.0007602851 9.409275e-02 0.319290211 12 1800007 1800052 46 - 1.329 1.225 -0.365
ENSG00000151062 E032 6.0352703 0.0056259433 4.871418e-02 0.217470077 12 1800053 1800179 127 - 0.579 0.855 1.143
ENSG00000151062 E033 3.0234581 0.1023364482 1.732119e-01 0.446295716 12 1800180 1800206 27 - 0.342 0.619 1.400
ENSG00000151062 E034 3.6593917 0.1217614713 9.764591e-02 0.325711833 12 1800207 1800227 21 - 0.342 0.691 1.708
ENSG00000151062 E035 8.1468077 0.0024710360 1.244524e-01 0.373856408 12 1800228 1800385 158 - 0.762 0.953 0.736
ENSG00000151062 E036 22.4321458 0.0006682423 5.238735e-02 0.227456079 12 1800386 1800438 53 - 1.396 1.283 -0.395
ENSG00000151062 E037 0.0000000       12 1800613 1800756 144 -      
ENSG00000151062 E038 14.4245414 0.0013657764 6.672208e-01 0.861525876 12 1801043 1801048 6 - 1.151 1.130 -0.076
ENSG00000151062 E039 27.1600119 0.0006473072 5.719710e-02 0.239016357 12 1801049 1801118 70 - 1.467 1.366 -0.347
ENSG00000151062 E040 12.6657014 0.0206731102 2.815609e-01 0.574932947 12 1801574 1801644 71 - 1.151 1.056 -0.343
ENSG00000151062 E041 0.3717172 0.2369768780 7.566435e-01   12 1802961 1803079 119 - 0.146 0.114 -0.408
ENSG00000151062 E042 0.2539903 0.0160945415 1.000000e+00   12 1809379 1809567 189 - 0.000 0.114 12.461
ENSG00000151062 E043 23.6917771 0.0006302499 4.755500e-05 0.001279262 12 1810278 1810340 63 - 1.501 1.262 -0.828
ENSG00000151062 E044 15.0341074 0.0159964178 3.408776e-03 0.038032467 12 1810543 1810587 45 - 1.321 1.073 -0.880
ENSG00000151062 E045 16.4180411 0.0093533504 4.603735e-03 0.046708205 12 1811662 1811723 62 - 1.337 1.120 -0.767
ENSG00000151062 E046 4.1954771 0.0886765944 3.019423e-01 0.595199341 12 1811724 1811798 75 - 0.791 0.619 -0.713
ENSG00000151062 E047 0.6354303 0.0257834272 2.090321e-01 0.493216341 12 1832262 1832293 32 - 0.000 0.243 13.624
ENSG00000151062 E048 2.0208087 0.1312767832 7.531303e-02 0.280169197 12 1840739 1840819 81 - 0.146 0.512 2.500
ENSG00000151062 E049 1.3948194 0.1012115987 3.491420e-02 0.178726492 12 1844402 1844424 23 - 0.000 0.424 14.457
ENSG00000151062 E050 3.5536580 0.0071939912 8.097722e-05 0.001991530 12 1844425 1844529 105 - 0.000 0.717 15.645
ENSG00000151062 E051 3.6699989 0.0068659853 9.082857e-04 0.013936695 12 1846594 1846689 96 - 0.146 0.717 3.400
ENSG00000151062 E052 3.2814134 0.0043571941 1.443860e-02 0.102397283 12 1853951 1854044 94 - 0.255 0.663 2.178
ENSG00000151062 E053 2.7740034 0.0258433805 4.727350e-02 0.213634391 12 1856012 1856109 98 - 0.255 0.603 1.915
ENSG00000151062 E054 1.8945556 0.0073008238 4.895470e-02 0.218064324 12 1856184 1856229 46 - 0.146 0.492 2.400
ENSG00000151062 E055 1.9046879 0.0074973442 5.474558e-03 0.052858006 12 1858577 1858644 68 - 0.000 0.513 14.966
ENSG00000151062 E056 1.1335609 0.0109886997 2.613218e-01 0.554014550 12 1860145 1860206 62 - 0.146 0.343 1.593
ENSG00000151062 E057 1.7694028 0.0801779580 9.194092e-02 0.314877123 12 1874604 1874675 72 - 0.146 0.470 2.294
ENSG00000151062 E058 2.1503060 0.0063919896 2.776003e-02 0.155505774 12 1875251 1875337 87 - 0.146 0.532 2.593
ENSG00000151062 E059 1.7689888 0.0097034564 6.576663e-02 0.258324765 12 1878315 1878389 75 - 0.146 0.470 2.293
ENSG00000151062 E060 0.1271363 0.0124024640 1.000000e+00   12 1878390 1878441 52 - 0.000 0.061 11.533
ENSG00000151062 E061 2.1596855 0.0066714102 2.793909e-03 0.032715305 12 1878956 1879036 81 - 0.000 0.551 15.107
ENSG00000151062 E062 2.2859102 0.0061758034 1.991483e-03 0.025494571 12 1879804 1879881 78 - 0.000 0.569 15.171
ENSG00000151062 E063 2.0294331 0.0191382594 4.378035e-03 0.045191372 12 1882867 1882986 120 - 0.000 0.532 15.017
ENSG00000151062 E064 1.1424347 0.0108117627 4.431521e-02 0.205852700 12 1882987 1883000 14 - 0.000 0.372 14.371
ENSG00000151062 E065 0.8889477 0.0139770929 9.337412e-02 0.317671103 12 1884030 1884242 213 - 0.000 0.312 14.064
ENSG00000151062 E066 2.3943487 0.0059725415 8.384784e-02 0.298745446 12 1884243 1884321 79 - 0.255 0.551 1.681
ENSG00000151062 E067 2.9007541 0.0078126277 3.200910e-02 0.169169885 12 1884768 1884881 114 - 0.255 0.619 1.985
ENSG00000151062 E068 0.1272623 0.0123325004 1.000000e+00   12 1884978 1884986 9 - 0.000 0.061 11.533
ENSG00000151062 E069 1.6483368 0.0975337263 1.981352e-02 0.126195353 12 1884987 1885076 90 - 0.000 0.470 14.657
ENSG00000151062 E070 1.5211390 0.0617374559 2.060729e-02 0.129331138 12 1885965 1885999 35 - 0.000 0.448 14.617
ENSG00000151062 E071 1.1419649 0.0117915583 4.433961e-02 0.205852700 12 1886000 1886039 40 - 0.000 0.372 14.369
ENSG00000151062 E072 2.8997570 0.0463010003 4.496309e-02 0.207303743 12 1886223 1886373 151 - 0.255 0.619 1.985
ENSG00000151062 E073 1.0084707 0.0130274691 3.436368e-01 0.634889955 12 1887009 1887069 61 - 0.146 0.312 1.400
ENSG00000151062 E074 2.3758786 0.0059225757 5.745024e-01 0.809478316 12 1907440 1907571 132 - 0.414 0.513 0.500
ENSG00000151062 E075 2.3589796 0.0059424119 6.359740e-01 0.844730284 12 1907875 1908037 163 - 0.530 0.470 -0.291
ENSG00000151062 E076 1.1356680 0.0281819816 2.702425e-01 0.563970640 12 1909906 1909965 60 - 0.146 0.343 1.593
ENSG00000151062 E077 1.8865954 0.0073001483 2.142266e-01 0.499450045 12 1913023 1913139 117 - 0.255 0.470 1.294
ENSG00000151062 E078 1.8848670 0.0892536358 2.718891e-01 0.565655956 12 1914854 1914935 82 - 0.255 0.470 1.293
ENSG00000151062 E079 0.0000000       12 1915193 1915227 35 -      
ENSG00000151062 E080 4.6660668 0.0054061045 4.697173e-03 0.047394881 12 1918247 1918666 420 - 0.342 0.786 2.096

Help

Please Click HERE to learn more details about the results from DEXseq.