ENSG00000153989

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000368494 ENSG00000153989 No_inf pgKDN_inf NUS1 protein_coding protein_coding 49.00378 34.37346 60.80887 0.4271533 1.033384 0.8228044 31.60082 16.09808 41.70827 1.188736 2.386678 1.3728950 0.6233583 0.469525 0.6856 0.216075 0.03621529 0.03621529 FALSE TRUE
MSTRG.25206.2 ENSG00000153989 No_inf pgKDN_inf NUS1 protein_coding   49.00378 34.37346 60.80887 0.4271533 1.033384 0.8228044 15.40236 16.67521 19.10060 2.667610 2.128039 0.1958027 0.3320917 0.482875 0.3144 -0.168475 0.41637798 0.03621529 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000153989 E001 8.2188176 0.0240640344 0.3752517758 0.662786430 6 117675469 117676085 617 + 0.991 0.888 -0.390
ENSG00000153989 E002 0.6088049 0.1674828129 0.9050452872 0.969544999 6 117689804 117689843 40 + 0.194 0.215 0.188
ENSG00000153989 E003 0.4999558 0.0153225265 0.1268124150 0.377456339 6 117691730 117691777 48 + 0.075 0.292 2.358
ENSG00000153989 E004 17.8448592 0.0094111241 0.0677671438 0.262717777 6 117693042 117693167 126 + 1.315 1.169 -0.515
ENSG00000153989 E005 49.9089129 0.0003842008 0.0269904489 0.152669415 6 117694031 117694180 150 + 1.729 1.636 -0.317
ENSG00000153989 E006 17.4029357 0.0008805800 0.1502197049 0.412704240 6 117703605 117703704 100 + 1.291 1.188 -0.364
ENSG00000153989 E007 339.4150525 0.0002428524 0.0003713532 0.006896888 6 117706925 117710727 3803 + 2.509 2.538 0.095

Help

Please Click HERE to learn more details about the results from DEXseq.