ENSG00000161547

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000359995 ENSG00000161547 No_inf pgKDN_inf SRSF2 protein_coding protein_coding 171.4214 169.889 176.2647 4.708475 5.764982 0.05314829 104.19434 71.10488 128.781863 3.970900 3.537350 0.8568181 0.60713333 0.418075 0.731550 0.313475 2.894387e-16 2.894387e-16 FALSE TRUE
ENST00000392485 ENSG00000161547 No_inf pgKDN_inf SRSF2 protein_coding protein_coding 171.4214 169.889 176.2647 4.708475 5.764982 0.05314829 18.94995 23.80558 16.384381 2.432328 2.286780 -0.5387042 0.11183333 0.141275 0.094300 -0.046975 5.258284e-01 2.894387e-16 FALSE TRUE
ENST00000582449 ENSG00000161547 No_inf pgKDN_inf SRSF2 protein_coding retained_intron 171.4214 169.889 176.2647 4.708475 5.764982 0.05314829 15.24039 25.57288 9.993017 2.628442 2.430160 -1.3547434 0.08931667 0.151525 0.056900 -0.094625 3.027233e-02 2.894387e-16 TRUE FALSE
ENST00000586778 ENSG00000161547 No_inf pgKDN_inf SRSF2 protein_coding retained_intron 171.4214 169.889 176.2647 4.708475 5.764982 0.05314829 19.87787 32.41657 11.912465 2.240053 2.539894 -1.4434939 0.11577500 0.190250 0.066825 -0.123425 1.034268e-03 2.894387e-16   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000161547 E001 3.533825 9.285815e-03 4.668270e-01 7.354417e-01 17 76734115 76734122 8 - 0.704 0.609 -0.404
ENSG00000161547 E002 8.661067 2.547735e-03 2.648456e-01 5.578450e-01 17 76734123 76734146 24 - 1.037 0.932 -0.390
ENSG00000161547 E003 10.520783 1.310527e-03 5.849181e-01 8.155353e-01 17 76734147 76734162 16 - 1.085 1.038 -0.172
ENSG00000161547 E004 61.000456 3.891301e-03 6.995428e-01 8.775976e-01 17 76734163 76734251 89 - 1.801 1.783 -0.058
ENSG00000161547 E005 83.020599 2.398220e-04 8.025099e-01 9.264424e-01 17 76734252 76734302 51 - 1.919 1.927 0.027
ENSG00000161547 E006 337.683875 6.837093e-05 3.836703e-02 1.891488e-01 17 76734303 76734562 260 - 2.545 2.514 -0.102
ENSG00000161547 E007 69.493845 1.698386e-03 9.928676e-02 3.290685e-01 17 76734563 76734576 14 - 1.880 1.816 -0.217
ENSG00000161547 E008 420.701090 5.925759e-05 2.741185e-08 1.792814e-06 17 76734577 76735060 484 - 2.660 2.590 -0.235
ENSG00000161547 E009 126.209931 1.579302e-04 4.533562e-01 7.261400e-01 17 76735061 76735136 76 - 2.114 2.094 -0.066
ENSG00000161547 E010 64.959369 2.279629e-04 3.940217e-02 1.923531e-01 17 76735137 76735158 22 - 1.775 1.852 0.258
ENSG00000161547 E011 104.960128 1.551453e-04 7.877720e-27 3.726991e-24 17 76735159 76735617 459 - 1.821 2.145 1.089
ENSG00000161547 E012 45.702986 3.104890e-04 8.476240e-08 5.008727e-06 17 76735618 76735771 154 - 1.522 1.764 0.825
ENSG00000161547 E013 30.157179 4.630159e-04 4.012086e-07 2.029905e-05 17 76735772 76735875 104 - 1.318 1.601 0.976
ENSG00000161547 E014 11.427141 1.220528e-03 6.085700e-04 1.017125e-02 17 76735876 76736153 278 - 0.909 1.207 1.088
ENSG00000161547 E015 20.465430 7.279353e-04 8.145957e-01 9.323260e-01 17 76736154 76736379 226 - 1.339 1.324 -0.053
ENSG00000161547 E016 0.000000       17 76736380 76736404 25 -      
ENSG00000161547 E017 0.000000       17 76736405 76736443 39 -      
ENSG00000161547 E018 0.000000       17 76736444 76736449 6 -      
ENSG00000161547 E019 0.000000       17 76736450 76736464 15 -      
ENSG00000161547 E020 0.000000       17 76736465 76736555 91 -      
ENSG00000161547 E021 0.000000       17 76736799 76736834 36 -      
ENSG00000161547 E022 67.888702 2.436806e-04 9.663348e-05 2.306119e-03 17 76736835 76737333 499 - 1.907 1.766 -0.475

Help

Please Click HERE to learn more details about the results from DEXseq.