ENSG00000163513

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000295754 ENSG00000163513 No_inf pgKDN_inf TGFBR2 protein_coding protein_coding 46.91699 80.99809 37.7739 0.4146219 0.3684888 -1.100294 16.432940 23.906958 13.719573 0.5532612 1.7118178 -0.80074721 0.39624167 0.295200 0.362975 0.067775 7.873303e-01 7.820876e-06 FALSE TRUE
ENST00000359013 ENSG00000163513 No_inf pgKDN_inf TGFBR2 protein_coding protein_coding 46.91699 80.99809 37.7739 0.4146219 0.3684888 -1.100294 3.510672 4.991393 4.866128 0.7266077 1.3507531 -0.03659396 0.07373333 0.061550 0.128975 0.067425 5.515686e-01 7.820876e-06 FALSE TRUE
ENST00000672050 ENSG00000163513 No_inf pgKDN_inf TGFBR2 protein_coding protein_coding_CDS_not_defined 46.91699 80.99809 37.7739 0.4146219 0.3684888 -1.100294 4.264300 10.389212 0.000000 3.7545878 0.0000000 -10.02225854 0.08080000 0.128925 0.000000 -0.128925 7.820876e-06 7.820876e-06   FALSE
ENST00000673203 ENSG00000163513 No_inf pgKDN_inf TGFBR2 protein_coding retained_intron 46.91699 80.99809 37.7739 0.4146219 0.3684888 -1.100294 22.623051 41.472360 19.188202 4.0927439 0.4290698 -1.11152677 0.44794167 0.511400 0.508025 -0.003375 1.000000e+00 7.820876e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000163513 E001 17.940536 0.0007279954 1.534057e-01 4.180035e-01 3 30606601 30606977 377 + 1.307 1.205 -0.361
ENSG00000163513 E002 0.000000       3 30614564 30614706 143 +      
ENSG00000163513 E003 3.800267 0.0037785658 3.757306e-02 1.868743e-01 3 30623199 30623273 75 + 0.817 0.554 -1.106
ENSG00000163513 E004 1.141271 0.0113390101 2.609328e-02 1.493965e-01 3 30631157 30632846 1690 + 0.000 0.390 11.878
ENSG00000163513 E005 26.298906 0.0005642591 7.281616e-03 6.482777e-02 3 30644747 30644915 169 + 1.502 1.342 -0.552
ENSG00000163513 E006 33.524397 0.0005947969 7.755292e-01 9.138019e-01 3 30650270 30650460 191 + 1.507 1.492 -0.053
ENSG00000163513 E007 125.966765 0.0001525962 2.085382e-03 2.638353e-02 3 30671638 30672437 800 + 2.119 2.035 -0.282
ENSG00000163513 E008 0.117004 0.0116933851 2.148887e-01   3 30673973 30674104 132 + 0.137 0.000 -11.330
ENSG00000163513 E009 31.802433 0.0056849337 9.445015e-02 3.198188e-01 3 30674105 30674246 142 + 1.546 1.442 -0.357
ENSG00000163513 E010 3.420449 0.0449977931 1.152934e-03 1.670875e-02 3 30681220 30681499 280 + 0.137 0.716 3.501
ENSG00000163513 E011 37.744131 0.0030182918 4.556521e-02 2.088643e-01 3 30688384 30688511 128 + 1.621 1.512 -0.374
ENSG00000163513 E012 909.773442 0.0000508960 2.557663e-07 1.357726e-05 3 30691420 30694142 2723 + 2.896 2.925 0.097

Help

Please Click HERE to learn more details about the results from DEXseq.