ENSG00000166454

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000299575 ENSG00000166454 No_inf pgKDN_inf ATMIN protein_coding protein_coding 11.41035 11.69627 12.7299 0.2337043 0.4457624 0.1220734 9.3786821 8.647102 10.7834394 0.5621852 0.98666062 0.3181986 0.82873333 0.737925 0.85730 0.119375 0.4243344 0.0249465 FALSE TRUE
ENST00000564241 ENSG00000166454 No_inf pgKDN_inf ATMIN protein_coding protein_coding 11.41035 11.69627 12.7299 0.2337043 0.4457624 0.1220734 0.3617289 0.000000 1.0851868 0.0000000 1.08518683 6.7750332 0.02576667 0.000000 0.07730 0.077300 0.8448565 0.0249465 FALSE TRUE
ENST00000566488 ENSG00000166454 No_inf pgKDN_inf ATMIN protein_coding protein_coding 11.41035 11.69627 12.7299 0.2337043 0.4457624 0.1220734 1.2485665 2.412481 0.5367385 0.1825397 0.01151293 -2.1475624 0.10965000 0.206325 0.04225 -0.164075 0.0249465 0.0249465 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000166454 E001 2.6877713 0.169307062 6.809540e-01 0.8681671485 16 81035842 81036057 216 + 0.605 0.528 -0.352
ENSG00000166454 E002 6.6565917 0.002087796 2.560540e-01 0.5481239095 16 81036058 81036206 149 + 0.816 0.934 0.453
ENSG00000166454 E003 0.1186381 0.011750887 5.062063e-01   16 81037182 81037186 5 + 0.098 0.000 -10.256
ENSG00000166454 E004 0.1186381 0.011750887 5.062063e-01   16 81037187 81037207 21 + 0.098 0.000 -10.256
ENSG00000166454 E005 0.4912665 0.046242259 9.574698e-01   16 81037208 81037475 268 + 0.177 0.169 -0.088
ENSG00000166454 E006 0.0000000       16 81037476 81037498 23 +      
ENSG00000166454 E007 5.7661734 0.002417571 1.107205e-05 0.0003736922 16 81040525 81041355 831 + 0.480 1.001 2.160
ENSG00000166454 E008 8.3873411 0.020581945 2.236662e-01 0.5112180206 16 81041356 81041481 126 + 0.893 1.031 0.515
ENSG00000166454 E009 0.0000000       16 81041482 81041711 230 +      
ENSG00000166454 E010 14.0869747 0.001374412 8.134388e-01 0.9317025459 16 81042281 81042480 200 + 1.187 1.169 -0.062
ENSG00000166454 E011 261.2060684 0.000126619 1.199806e-02 0.0905292794 16 81043161 81047350 4190 + 2.426 2.410 -0.055

Help

Please Click HERE to learn more details about the results from DEXseq.