ENSG00000166949

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000327367 ENSG00000166949 No_inf pgKDN_inf SMAD3 protein_coding protein_coding 12.47768 10.6407 13.29564 0.403971 1.419509 0.3210899 4.1034058 3.945522 5.159010 0.5079526 0.5811272 0.386020 0.33868333 0.367400 0.409725 0.042325 9.437286e-01 1.251405e-05 FALSE TRUE
ENST00000558827 ENSG00000166949 No_inf pgKDN_inf SMAD3 protein_coding protein_coding 12.47768 10.6407 13.29564 0.403971 1.419509 0.3210899 0.5266152 0.000000 1.579846 0.0000000 0.9169735 7.312743 0.03567500 0.000000 0.107025 0.107025 4.809617e-01 1.251405e-05 FALSE FALSE
ENST00000558894 ENSG00000166949 No_inf pgKDN_inf SMAD3 protein_coding protein_coding 12.47768 10.6407 13.29564 0.403971 1.419509 0.3210899 0.6305584 0.000000 1.891675 0.0000000 1.1128624 7.571127 0.04205833 0.000000 0.126175 0.126175 4.778182e-01 1.251405e-05 FALSE FALSE
ENST00000560402 ENSG00000166949 No_inf pgKDN_inf SMAD3 protein_coding retained_intron 12.47768 10.6407 13.29564 0.403971 1.419509 0.3210899 1.4496128 3.230186 0.721959 0.6368284 0.4198192 -2.146242 0.12360000 0.299000 0.051700 -0.247300 8.225837e-02 1.251405e-05 FALSE FALSE
ENST00000679624 ENSG00000166949 No_inf pgKDN_inf SMAD3 protein_coding protein_coding 12.47768 10.6407 13.29564 0.403971 1.419509 0.3210899 2.2974845 3.076780 0.000000 0.6778996 0.0000000 -8.269959 0.20575833 0.297225 0.000000 -0.297225 1.251405e-05 1.251405e-05 FALSE TRUE
ENST00000681239 ENSG00000166949 No_inf pgKDN_inf SMAD3 protein_coding protein_coding 12.47768 10.6407 13.29564 0.403971 1.419509 0.3210899 0.9837729 0.000000 2.951319 0.0000000 1.0953354 8.210096 0.07810000 0.000000 0.234300 0.234300 3.987972e-02 1.251405e-05 FALSE TRUE
MSTRG.9824.3 ENSG00000166949 No_inf pgKDN_inf SMAD3 protein_coding   12.47768 10.6407 13.29564 0.403971 1.419509 0.3210899 0.6189545 0.000000 0.000000 0.0000000 0.0000000 0.000000 0.05027500 0.000000 0.000000 0.000000   1.251405e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000166949 E001 0.0000000       15 67063763 67063944 182 +      
ENSG00000166949 E002 1.6024514 0.0900597031 4.536547e-01 0.7263808536 15 67065602 67065820 219 + 0.345 0.473 0.702
ENSG00000166949 E003 12.9545957 0.0036509949 6.450943e-01 0.8497378862 15 67065821 67066360 540 + 1.164 1.125 -0.140
ENSG00000166949 E004 0.0000000       15 67067785 67067913 129 +      
ENSG00000166949 E005 0.0000000       15 67077986 67078041 56 +      
ENSG00000166949 E006 0.0000000       15 67098582 67098678 97 +      
ENSG00000166949 E007 0.0000000       15 67098679 67098768 90 +      
ENSG00000166949 E008 0.1265070 0.0122505906 5.263042e-01   15 67098769 67099024 256 + 0.000 0.096 11.656
ENSG00000166949 E009 0.0000000       15 67125716 67125984 269 +      
ENSG00000166949 E010 0.0000000       15 67128103 67128151 49 +      
ENSG00000166949 E011 0.0000000       15 67138001 67138100 100 +      
ENSG00000166949 E012 0.2356421 0.0156582187 2.499961e-01   15 67138235 67138522 288 + 0.172 0.000 -13.507
ENSG00000166949 E013 0.0000000       15 67139566 67139722 157 +      
ENSG00000166949 E014 12.4982600 0.0151167582 4.223112e-02 0.2000433321 15 67164895 67165088 194 + 1.218 1.026 -0.691
ENSG00000166949 E015 10.1335349 0.0014868230 5.045320e-01 0.7636493866 15 67165253 67165384 132 + 1.076 1.016 -0.220
ENSG00000166949 E016 0.1271363 0.0123166221 5.262393e-01   15 67166019 67166193 175 + 0.000 0.096 11.656
ENSG00000166949 E017 0.1186381 0.0117878498 5.502451e-01   15 67166531 67166691 161 + 0.094 0.000 -12.581
ENSG00000166949 E018 0.0000000       15 67166692 67166778 87 +      
ENSG00000166949 E019 7.7769209 0.0018815715 9.599744e-02 0.3227197181 15 67166779 67166853 75 + 1.020 0.855 -0.618
ENSG00000166949 E020 8.4316819 0.0080338244 6.255471e-01 0.8389419146 15 67170554 67170604 51 + 0.999 0.949 -0.186
ENSG00000166949 E021 0.1272623 0.0123828453 5.261214e-01   15 67170605 67170675 71 + 0.000 0.096 11.656
ENSG00000166949 E022 0.2543986 0.0160699118 2.345905e-01   15 67174303 67174584 282 + 0.000 0.174 12.592
ENSG00000166949 E023 1.1245934 0.0111732410 8.370751e-02 0.2984188972 15 67180880 67181240 361 + 0.172 0.436 1.831
ENSG00000166949 E024 16.4904459 0.0016679931 4.133749e-01 0.6941794376 15 67181241 67181453 213 + 1.272 1.212 -0.212
ENSG00000166949 E025 7.5197262 0.0020506988 5.111305e-02 0.2238151456 15 67184727 67184774 48 + 1.020 0.824 -0.738
ENSG00000166949 E026 8.2624843 0.0126080923 1.368698e-01 0.3937662048 15 67184775 67184864 90 + 1.040 0.884 -0.579
ENSG00000166949 E027 0.4828984 0.0255155453 3.326454e-01   15 67186662 67187019 358 + 0.238 0.096 -1.562
ENSG00000166949 E028 0.2340080 0.2534090834 3.052919e-01   15 67187020 67187130 111 + 0.172 0.000 -12.885
ENSG00000166949 E029 0.3526461 0.0279783768 1.090654e-01   15 67187131 67187364 234 + 0.238 0.000 -13.986
ENSG00000166949 E030 7.4618760 0.0053088092 7.772103e-01 0.9144537577 15 67187365 67187509 145 + 0.943 0.911 -0.119
ENSG00000166949 E031 11.3690815 0.0017477264 6.823584e-01 0.8685848222 15 67190413 67190590 178 + 1.110 1.074 -0.132
ENSG00000166949 E032 11.4214390 0.0064419959 9.618537e-02 0.3230376549 15 67190591 67190705 115 + 1.164 1.016 -0.536
ENSG00000166949 E033 82.3485746 0.0002592497 8.083392e-01 0.9292359816 15 67190706 67192872 2167 + 1.926 1.916 -0.032
ENSG00000166949 E034 128.3366664 0.0001723744 6.334165e-06 0.0002300518 15 67192873 67195182 2310 + 2.061 2.154 0.312

Help

Please Click HERE to learn more details about the results from DEXseq.