ENSG00000168010

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000435507 ENSG00000168010 No_inf pgKDN_inf ATG16L2 protein_coding nonsense_mediated_decay 25.42972 54.03205 8.50508 6.330903 1.523527 -2.66599 0.5088656 0.3523038 1.1742930 0.2169818 0.6929863 1.708754 0.05225000 0.007800 0.148950 0.141150 0.550366359 0.002068489 FALSE TRUE
ENST00000534905 ENSG00000168010 No_inf pgKDN_inf ATG16L2 protein_coding protein_coding 25.42972 54.03205 8.50508 6.330903 1.523527 -2.66599 1.9325431 3.0589569 1.1751788 0.1290008 0.4566721 -1.372644 0.09944167 0.059425 0.125175 0.065750 0.607293165 0.002068489 FALSE TRUE
ENST00000536995 ENSG00000168010 No_inf pgKDN_inf ATG16L2 protein_coding retained_intron 25.42972 54.03205 8.50508 6.330903 1.523527 -2.66599 1.5735551 2.6012350 0.6847004 0.1201415 0.1197257 -1.910269 0.08237500 0.050350 0.091150 0.040800 0.819939105 0.002068489   FALSE
ENST00000540222 ENSG00000168010 No_inf pgKDN_inf ATG16L2 protein_coding protein_coding 25.42972 54.03205 8.50508 6.330903 1.523527 -2.66599 2.4502959 3.6918824 0.0000000 2.1346017 0.0000000 -8.532115 0.11064167 0.073425 0.000000 -0.073425 0.829478471 0.002068489 FALSE TRUE
ENST00000541367 ENSG00000168010 No_inf pgKDN_inf ATG16L2 protein_coding protein_coding 25.42972 54.03205 8.50508 6.330903 1.523527 -2.66599 0.3000076 0.0000000 0.9000227 0.0000000 0.9000227 6.507831 0.03423333 0.000000 0.102700 0.102700 0.552182952 0.002068489 FALSE TRUE
ENST00000541554 ENSG00000168010 No_inf pgKDN_inf ATG16L2 protein_coding protein_coding 25.42972 54.03205 8.50508 6.330903 1.523527 -2.66599 5.4656963 16.3970890 0.0000000 5.6357079 0.0000000 -10.680104 0.09275833 0.278275 0.000000 -0.278275 0.044928582 0.002068489 FALSE FALSE
MSTRG.5162.14 ENSG00000168010 No_inf pgKDN_inf ATG16L2 protein_coding   25.42972 54.03205 8.50508 6.330903 1.523527 -2.66599 2.4745881 6.6880217 0.0000000 1.6662963 0.0000000 -9.387591 0.05732500 0.122000 0.000000 -0.122000 0.002068489 0.002068489 FALSE TRUE
MSTRG.5162.18 ENSG00000168010 No_inf pgKDN_inf ATG16L2 protein_coding   25.42972 54.03205 8.50508 6.330903 1.523527 -2.66599 0.3980861 0.0000000 1.1942582 0.0000000 0.6981019 6.912001 0.04508333 0.000000 0.135250 0.135250 0.111441498 0.002068489 TRUE FALSE
MSTRG.5162.28 ENSG00000168010 No_inf pgKDN_inf ATG16L2 protein_coding   25.42972 54.03205 8.50508 6.330903 1.523527 -2.66599 0.8196919 2.4590758 0.0000000 1.4248242 0.0000000 -7.947827 0.01675000 0.050250 0.000000 -0.050250 0.834711985 0.002068489   FALSE
MSTRG.5162.4 ENSG00000168010 No_inf pgKDN_inf ATG16L2 protein_coding   25.42972 54.03205 8.50508 6.330903 1.523527 -2.66599 1.2963520 2.3077941 0.0000000 1.4075710 0.0000000 -7.856609 0.05645833 0.054325 0.000000 -0.054325 0.840127184 0.002068489 FALSE FALSE
MSTRG.5162.5 ENSG00000168010 No_inf pgKDN_inf ATG16L2 protein_coding   25.42972 54.03205 8.50508 6.330903 1.523527 -2.66599 3.6980457 8.3367005 1.4312683 0.9723051 0.5099153 -2.533867 0.15260000 0.155025 0.205050 0.050025 0.999181536 0.002068489 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000168010 E001 0.1186381 0.0117247632 6.281278e-02   11 72814406 72814410 5 + 0.196 0.000 -11.858
ENSG00000168010 E002 0.1186381 0.0117247632 6.281278e-02   11 72814411 72814414 4 + 0.196 0.000 -14.456
ENSG00000168010 E003 0.1186381 0.0117247632 6.281278e-02   11 72814415 72814417 3 + 0.196 0.000 -14.456
ENSG00000168010 E004 0.2454921 0.0161804855 1.871648e-01   11 72814418 72814418 1 + 0.196 0.043 -2.443
ENSG00000168010 E005 0.6262717 0.0151094767 7.784284e-01 0.9148664358 11 72814419 72814424 6 + 0.196 0.152 -0.443
ENSG00000168010 E006 0.6262717 0.0151094767 7.784284e-01 0.9148664358 11 72814425 72814426 2 + 0.196 0.152 -0.443
ENSG00000168010 E007 0.8701297 0.0130088624 3.889330e-01 0.6748394665 11 72814427 72814431 5 + 0.331 0.183 -1.121
ENSG00000168010 E008 5.3752579 0.0072485577 3.723814e-01 0.6603109909 11 72814432 72814563 132 + 0.788 0.660 -0.525
ENSG00000168010 E009 0.8703181 0.0130567655 3.876777e-01 0.6733768846 11 72815887 72816349 463 + 0.331 0.183 -1.121
ENSG00000168010 E010 3.7364929 0.0038797356 1.262214e-01 0.3767154285 11 72816728 72816744 17 + 0.746 0.520 -0.984
ENSG00000168010 E011 6.3682189 0.0023036069 1.453102e-01 0.4056292401 11 72816745 72816827 83 + 0.895 0.707 -0.742
ENSG00000168010 E012 6.1779225 0.0028206704 2.683824e-01 0.5618934740 11 72817756 72817855 100 + 0.586 0.750 0.695
ENSG00000168010 E013 88.5897221 0.0002369600 7.885041e-06 0.0002781372 11 72817856 72820136 2281 + 1.624 1.828 0.689
ENSG00000168010 E014 53.7535277 0.0030054246 2.122677e-02 0.1317672894 11 72820137 72821198 1062 + 1.470 1.608 0.472
ENSG00000168010 E015 17.9133175 0.0009957822 2.149221e-02 0.1327834027 11 72821199 72821547 349 + 0.925 1.163 0.868
ENSG00000168010 E016 7.3966059 0.0022151145 5.403955e-01 0.7884458305 11 72821548 72821667 120 + 0.862 0.781 -0.317
ENSG00000168010 E017 7.3666455 0.0029420108 1.097108e-01 0.3476174157 11 72821668 72821741 74 + 0.954 0.758 -0.758
ENSG00000168010 E018 4.8058534 0.0029243944 4.570480e-02 0.2093143468 11 72821888 72821918 31 + 0.331 0.679 1.727
ENSG00000168010 E019 5.1861299 0.0027396789 3.003209e-02 0.1630420433 11 72821919 72822043 125 + 0.331 0.707 1.842
ENSG00000168010 E020 11.9609374 0.0040694284 2.597900e-01 0.5523577380 11 72822044 72822188 145 + 0.862 0.992 0.490
ENSG00000168010 E021 4.8063324 0.0139993782 5.101124e-02 0.2235508332 11 72822189 72822214 26 + 0.331 0.679 1.727
ENSG00000168010 E022 4.4077327 0.0175629414 4.930469e-01 0.7550252437 11 72822215 72822233 19 + 0.516 0.629 0.511
ENSG00000168010 E023 6.5074572 0.0335362937 3.490342e-01 0.6395418828 11 72822234 72822295 62 + 0.862 0.725 -0.545
ENSG00000168010 E024 0.0000000       11 72822322 72822340 19 +      
ENSG00000168010 E025 0.1170040 0.0117344325 6.274577e-02   11 72822341 72822430 90 + 0.196 0.000 -14.456
ENSG00000168010 E026 0.1170040 0.0117344325 6.274577e-02   11 72822431 72822438 8 + 0.196 0.000 -14.456
ENSG00000168010 E027 0.2442663 0.0163769215 1.870003e-01   11 72822439 72822476 38 + 0.196 0.043 -2.443
ENSG00000168010 E028 0.3715287 0.1504308856 3.842973e-01   11 72822477 72822477 1 + 0.196 0.083 -1.442
ENSG00000168010 E029 4.7095462 0.0204946263 7.916291e-03 0.0686426435 11 72822478 72822482 5 + 0.925 0.559 -1.500
ENSG00000168010 E030 4.5815958 0.0382565758 8.698748e-03 0.0732487530 11 72822483 72822487 5 + 0.925 0.546 -1.558
ENSG00000168010 E031 9.7466727 0.0015537807 8.819211e-02 0.3079672069 11 72822488 72822543 56 + 1.052 0.863 -0.706
ENSG00000168010 E032 8.8765764 0.0018236073 1.310173e-01 0.3839803517 11 72822544 72822847 304 + 1.006 0.831 -0.662
ENSG00000168010 E033 12.2822972 0.0047997523 6.586049e-01 0.8573372533 11 72822848 72822961 114 + 1.029 0.978 -0.190
ENSG00000168010 E034 27.9578835 0.0039602625 5.760763e-01 0.8104148948 11 72822962 72823543 582 + 1.356 1.310 -0.159
ENSG00000168010 E035 13.2606478 0.0029917100 1.673824e-01 0.4380630378 11 72823544 72823765 222 + 1.132 0.992 -0.510
ENSG00000168010 E036 4.1323483 0.0038076756 6.967079e-01 0.8761686032 11 72823766 72823797 32 + 0.646 0.584 -0.273
ENSG00000168010 E037 7.5250325 0.0019574213 8.323280e-01 0.9394870967 11 72823798 72823894 97 + 0.827 0.796 -0.121
ENSG00000168010 E038 12.3144593 0.0011404836 7.018026e-01 0.8786806107 11 72823895 72824059 165 + 0.954 0.992 0.142
ENSG00000168010 E039 10.5661420 0.0012803765 5.051616e-01 0.7641267688 11 72824060 72824122 63 + 0.862 0.938 0.287
ENSG00000168010 E040 0.8796629 0.0134827176 1.000000e+00 1.0000000000 11 72824123 72824126 4 + 0.196 0.212 0.142
ENSG00000168010 E041 1.2611979 0.0735795943 6.571250e-01 0.8565376194 11 72824127 72824206 80 + 0.196 0.289 0.727
ENSG00000168010 E042 6.0386341 0.0031649808 5.362480e-01 0.7856463399 11 72824207 72824491 285 + 0.646 0.733 0.364
ENSG00000168010 E043 4.0289385 0.0037038508 6.137626e-01 0.8320808098 11 72824492 72824733 242 + 0.516 0.595 0.364
ENSG00000168010 E044 17.6895268 0.0072199438 6.751652e-01 0.8654245874 11 72824734 72824842 109 + 1.167 1.123 -0.157
ENSG00000168010 E045 12.6953237 0.0065279501 8.201621e-01 0.9346983870 11 72825302 72825348 47 + 0.981 1.001 0.076
ENSG00000168010 E046 11.4416816 0.0036674258 7.159435e-01 0.8854739852 11 72825349 72825407 59 + 0.925 0.963 0.142
ENSG00000168010 E047 14.0648451 0.0031096438 8.856481e-01 0.9616004746 11 72826173 72826243 71 + 1.029 1.040 0.039
ENSG00000168010 E048 16.1976294 0.0009101115 9.586554e-01 0.9901969289 11 72826518 72826589 72 + 1.094 1.095 0.003
ENSG00000168010 E049 1.2536159 0.0101127914 7.171620e-01 0.8860850367 11 72826590 72826702 113 + 0.331 0.265 -0.443
ENSG00000168010 E050 25.0899917 0.0117997042 6.353905e-01 0.8443797399 11 72826703 72826823 121 + 1.310 1.265 -0.156
ENSG00000168010 E051 3.0025614 0.0093649332 5.101792e-01 0.7678020616 11 72826824 72827187 364 + 0.586 0.476 -0.517
ENSG00000168010 E052 21.5802577 0.0006548990 8.236328e-01 0.9359741824 11 72827188 72827293 106 + 1.230 1.207 -0.080
ENSG00000168010 E053 25.2692050 0.0008044703 4.864866e-01 0.7501242050 11 72828359 72828508 150 + 1.230 1.282 0.184
ENSG00000168010 E054 2.2568927 0.0062546081 9.081153e-01 0.9707321566 11 72828509 72828728 220 + 0.433 0.411 -0.121
ENSG00000168010 E055 9.7275113 0.0016735188 4.738184e-02 0.2139203119 11 72828729 72828776 48 + 1.074 0.857 -0.808
ENSG00000168010 E056 17.3136474 0.0020673494 2.067288e-03 0.0262145747 11 72828883 72828984 102 + 1.333 1.072 -0.926
ENSG00000168010 E057 24.6840464 0.0046648197 3.403418e-01 0.6319630721 11 72829303 72829688 386 + 1.333 1.253 -0.282
ENSG00000168010 E058 1.2509441 0.0100985054 7.160964e-01 0.8855145670 11 72842617 72843674 1058 + 0.331 0.265 -0.443

Help

Please Click HERE to learn more details about the results from DEXseq.