ENSG00000168404

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000308807 ENSG00000168404 No_inf pgKDN_inf MLKL protein_coding protein_coding 5.844196 11.26934 2.263357 1.186454 0.4176026 -2.310787 1.5931272 2.1555600 1.5642833 0.8486822 0.5652669 -0.4600450 0.37799167 0.218675 0.633200 0.414525 5.186130e-01 9.754398e-05 FALSE TRUE
ENST00000571303 ENSG00000168404 No_inf pgKDN_inf MLKL protein_coding nonsense_mediated_decay 5.844196 11.26934 2.263357 1.186454 0.4176026 -2.310787 0.6989076 1.3843663 0.0000000 0.5107814 0.0000000 -7.1234658 0.10030000 0.121425 0.000000 -0.121425 3.163608e-01 9.754398e-05 TRUE TRUE
ENST00000573267 ENSG00000168404 No_inf pgKDN_inf MLKL protein_coding protein_coding 5.844196 11.26934 2.263357 1.186454 0.4176026 -2.310787 0.3215250 0.6457245 0.3188503 0.6457245 0.3188503 -0.9956588 0.04890833 0.046050 0.100675 0.054625 8.332610e-01 9.754398e-05 FALSE FALSE
MSTRG.11512.3 ENSG00000168404 No_inf pgKDN_inf MLKL protein_coding   5.844196 11.26934 2.263357 1.186454 0.4176026 -2.310787 2.4735800 5.8576519 0.0000000 1.2230213 0.0000000 -9.1966395 0.29606667 0.509200 0.000000 -0.509200 9.754398e-05 9.754398e-05 TRUE FALSE
MSTRG.11512.6 ENSG00000168404 No_inf pgKDN_inf MLKL protein_coding   5.844196 11.26934 2.263357 1.186454 0.4176026 -2.310787 0.4598837 0.6483402 0.2921919 0.4498632 0.2921919 -1.1233686 0.12093333 0.051050 0.210925 0.159875 1.000000e+00 9.754398e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000168404 E001 0.0000000       16 74671855 74671856 2 -      
ENSG00000168404 E002 4.2112963 0.020936000 0.077601042 0.2850316 16 74671857 74672097 241 - 0.810 0.591 -0.916
ENSG00000168404 E003 12.8360071 0.003751912 0.014521300 0.1027676 16 74672098 74672352 255 - 0.840 1.104 0.985
ENSG00000168404 E004 10.7801977 0.001480882 0.302643489 0.5957652 16 74672353 74672538 186 - 0.894 1.015 0.453
ENSG00000168404 E005 6.5108707 0.002404766 0.652771716 0.8538216 16 74674960 74675100 141 - 0.744 0.815 0.280
ENSG00000168404 E006 0.0000000       16 74675101 74675323 223 -      
ENSG00000168404 E007 0.1265070 0.013084047 1.000000000   16 74675324 74675354 31 - 0.000 0.054 10.103
ENSG00000168404 E008 2.6264378 0.006692079 0.765101996 0.9086608 16 74675355 74675404 50 - 0.450 0.510 0.297
ENSG00000168404 E009 0.1265070 0.013084047 1.000000000   16 74675405 74675612 208 - 0.000 0.054 10.103
ENSG00000168404 E010 1.6039622 0.010072739 0.168351480 0.4395328 16 74675613 74675617 5 - 0.515 0.312 -1.112
ENSG00000168404 E011 4.4577710 0.014301670 0.108501777 0.3455935 16 74675618 74675764 147 - 0.810 0.619 -0.790
ENSG00000168404 E012 1.3877393 0.009914553 0.283058360 0.5767025 16 74675765 74676300 536 - 0.163 0.365 1.532
ENSG00000168404 E013 1.2698565 0.010379990 0.069992542 0.2676909 16 74676301 74676425 125 - 0.000 0.365 12.897
ENSG00000168404 E014 2.9185099 0.005646506 0.001807309 0.0236304 16 74676426 74678413 1988 - 0.000 0.605 13.827
ENSG00000168404 E015 4.2585079 0.009449415 0.547575209 0.7930356 16 74678899 74678980 82 - 0.572 0.671 0.432
ENSG00000168404 E016 5.3925789 0.003150014 0.360804442 0.6503794 16 74682651 74682786 136 - 0.622 0.759 0.572
ENSG00000168404 E017 2.2479928 0.006808945 0.957534271 0.9898350 16 74685486 74685583 98 - 0.450 0.454 0.017
ENSG00000168404 E018 1.8781593 0.033214489 0.898602884 0.9666563 16 74691277 74691364 88 - 0.374 0.412 0.210
ENSG00000168404 E019 3.3669822 0.007262087 0.593853758 0.8211555 16 74691365 74691463 99 - 0.622 0.560 -0.276
ENSG00000168404 E020 0.1268540 0.012725632 1.000000000   16 74691464 74691469 6 - 0.000 0.054 10.103
ENSG00000168404 E021 2.8316504 0.062790310 0.036603942 0.1840915 16 74692342 74692416 75 - 0.744 0.433 -1.412
ENSG00000168404 E022 5.0809831 0.041777517 0.086945714 0.3055412 16 74695298 74695511 214 - 0.868 0.658 -0.842
ENSG00000168404 E023 3.9701854 0.042384867 0.258464554 0.5507933 16 74695512 74695721 210 - 0.744 0.591 -0.653
ENSG00000168404 E024 1.6305590 0.009276384 0.563811774 0.8030381 16 74695722 74695759 38 - 0.281 0.389 0.669
ENSG00000168404 E025 1.2413151 0.010545013 0.542575393 0.7897677 16 74700453 74700542 90 - 0.374 0.284 -0.568
ENSG00000168404 E026 1.2489929 0.012275528 0.904518154 0.9692883 16 74700543 74700682 140 - 0.281 0.312 0.210
ENSG00000168404 E027 0.8526669 0.013178481 0.043198421 0.2027202 16 74700683 74700960 278 - 0.450 0.145 -2.205

Help

Please Click HERE to learn more details about the results from DEXseq.