ENSG00000168476

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000306306 ENSG00000168476 No_inf pgKDN_inf REEP4 protein_coding protein_coding 39.53034 34.34113 38.32273 1.28529 0.531139 0.1582189 24.221668 13.265051 25.226355 2.4312554 1.4305627 0.9267861 0.60101667 0.393175 0.658400 0.265225 0.10635313 0.03740576 FALSE TRUE
ENST00000334530 ENSG00000168476 No_inf pgKDN_inf REEP4 protein_coding protein_coding 39.53034 34.34113 38.32273 1.28529 0.531139 0.1582189 2.041541 3.902020 0.000000 1.8058926 0.0000000 -8.6117698 0.05596667 0.117100 0.000000 -0.117100 0.03740576 0.03740576 TRUE TRUE
ENST00000519074 ENSG00000168476 No_inf pgKDN_inf REEP4 protein_coding retained_intron 39.53034 34.34113 38.32273 1.28529 0.531139 0.1582189 4.178118 5.834985 2.921248 0.6191526 0.6303103 -0.9956846 0.10970833 0.170925 0.075600 -0.095325 0.28189773 0.03740576 FALSE TRUE
MSTRG.27366.4 ENSG00000168476 No_inf pgKDN_inf REEP4 protein_coding   39.53034 34.34113 38.32273 1.28529 0.531139 0.1582189 7.584657 10.591666 9.179553 4.0407297 1.5525919 -0.2062244 0.19829167 0.298600 0.239825 -0.058775 1.00000000 0.03740576 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000168476 E001 0.2362687 0.0156871158 2.622206e-01   8 22138020 22138020 1 - 0.169 0.000 -11.842
ENSG00000168476 E002 32.5574273 0.0004853638 4.007464e-02 0.1940376938 8 22138021 22138250 230 - 1.470 1.575 0.360
ENSG00000168476 E003 64.3472420 0.0005894197 2.387789e-02 0.1414561940 8 22138251 22138552 302 - 1.772 1.854 0.274
ENSG00000168476 E004 38.8236486 0.0004218233 3.225770e-01 0.6155895068 8 22138639 22138793 155 - 1.622 1.578 -0.150
ENSG00000168476 E005 0.5077596 0.0150493647 3.929549e-02 0.1919553512 8 22138903 22138906 4 - 0.000 0.303 12.911
ENSG00000168476 E006 0.6348960 0.0143091224 1.730627e-02 0.1151631573 8 22138907 22138925 19 - 0.000 0.354 13.232
ENSG00000168476 E007 30.6356047 0.0006293625 3.045584e-01 0.5979880683 8 22138926 22139061 136 - 1.526 1.474 -0.178
ENSG00000168476 E008 11.2076664 0.0082326338 2.022429e-05 0.0006240142 8 22139062 22139415 354 - 0.841 1.240 1.465
ENSG00000168476 E009 36.5332917 0.0004446421 3.250017e-01 0.6174882904 8 22139416 22139529 114 - 1.549 1.598 0.164
ENSG00000168476 E010 0.9892386 0.0114135642 4.337907e-01 0.7110617873 8 22139802 22139962 161 - 0.234 0.354 0.824
ENSG00000168476 E011 32.4481382 0.0008262193 1.606974e-01 0.4287012938 8 22139963 22140064 102 - 1.558 1.488 -0.240
ENSG00000168476 E012 18.1305052 0.0245095660 1.873328e-01 0.4653782071 8 22140065 22140083 19 - 1.336 1.221 -0.401
ENSG00000168476 E013 21.7430941 0.0007831151 5.979994e-01 0.8237344805 8 22140172 22140205 34 - 1.372 1.341 -0.108
ENSG00000168476 E014 25.1623204 0.0005693489 5.620040e-01 0.8021134930 8 22140206 22140248 43 - 1.433 1.402 -0.110
ENSG00000168476 E015 0.9861876 0.0126988196 4.347777e-01 0.7118575142 8 22140607 22140624 18 - 0.234 0.354 0.824
ENSG00000168476 E016 26.2481874 0.0006721685 3.698029e-01 0.6580537542 8 22140625 22140697 73 - 1.459 1.410 -0.169
ENSG00000168476 E017 35.3204820 0.0004603227 4.021510e-02 0.1944036009 8 22141451 22141659 209 - 1.607 1.509 -0.334
ENSG00000168476 E018 21.8407399 0.0006118308 2.900290e-01 0.5836542141 8 22141660 22141884 225 - 1.389 1.326 -0.221
ENSG00000168476 E019 2.8132612 0.0050095212 9.431519e-01 0.9842108906 8 22141885 22141951 67 - 0.585 0.577 -0.039

Help

Please Click HERE to learn more details about the results from DEXseq.