ENSG00000175354

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000309660 ENSG00000175354 No_inf pgKDN_inf PTPN2 protein_coding protein_coding 45.39369 29.73497 70.53107 2.154903 33.72205 1.245818 2.8062751 2.436502 2.7697697 0.3328124 0.5063616 0.1842451 0.07634167 0.082625 0.056750 -0.025875 8.107489e-01 8.719326e-05 FALSE  
ENST00000327283 ENSG00000175354 No_inf pgKDN_inf PTPN2 protein_coding protein_coding 45.39369 29.73497 70.53107 2.154903 33.72205 1.245818 5.6557098 2.782104 5.8628185 1.6163327 2.5896238 1.0727005 0.16381667 0.102425 0.156475 0.054050 8.353706e-01 8.719326e-05 FALSE  
ENST00000585666 ENSG00000175354 No_inf pgKDN_inf PTPN2 protein_coding protein_coding 45.39369 29.73497 70.53107 2.154903 33.72205 1.245818 0.6040470 1.812141 0.0000000 0.4111359 0.0000000 -7.5094907 0.02093333 0.062800 0.000000 -0.062800 8.719326e-05 8.719326e-05 FALSE  
ENST00000587497 ENSG00000175354 No_inf pgKDN_inf PTPN2 protein_coding protein_coding_CDS_not_defined 45.39369 29.73497 70.53107 2.154903 33.72205 1.245818 0.9705773 1.785416 0.3971158 0.5814251 0.2355847 -2.1408074 0.02860833 0.059425 0.007400 -0.052025 1.051256e-01 8.719326e-05    
ENST00000587703 ENSG00000175354 No_inf pgKDN_inf PTPN2 protein_coding protein_coding 45.39369 29.73497 70.53107 2.154903 33.72205 1.245818 0.7250274 2.175082 0.0000000 2.1750823 0.0000000 -7.7715438 0.02010000 0.060300 0.000000 -0.060300 8.113044e-01 8.719326e-05 FALSE  
ENST00000589444 ENSG00000175354 No_inf pgKDN_inf PTPN2 protein_coding retained_intron 45.39369 29.73497 70.53107 2.154903 33.72205 1.245818 4.1583841 5.277528 2.9653175 0.5409839 0.2466713 -0.8295498 0.12145000 0.180400 0.065825 -0.114575 2.391121e-01 8.719326e-05    
ENST00000591901 ENSG00000175354 No_inf pgKDN_inf PTPN2 protein_coding protein_coding 45.39369 29.73497 70.53107 2.154903 33.72205 1.245818 2.3128520 1.817035 1.4519495 0.4188158 0.3302820 -0.3216107 0.06567500 0.064350 0.034125 -0.030225 7.688815e-01 8.719326e-05 FALSE  
ENST00000643900 ENSG00000175354 No_inf pgKDN_inf PTPN2 protein_coding protein_coding_CDS_not_defined 45.39369 29.73497 70.53107 2.154903 33.72205 1.245818 11.7631512 0.000000 35.2894535 0.0000000 35.2894535 11.7854301 0.06852500 0.000000 0.205575 0.205575 9.465617e-01 8.719326e-05    
MSTRG.13664.1 ENSG00000175354 No_inf pgKDN_inf PTPN2 protein_coding   45.39369 29.73497 70.53107 2.154903 33.72205 1.245818 13.7373130 10.016623 18.0054994 1.0208463 0.7219249 0.8454028 0.36378333 0.335625 0.386500 0.050875 9.579687e-01 8.719326e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000175354 E001 0.4730484 0.0158866210 7.113618e-02   18 12785478 12785480 3 - 0.274 0.000 -11.275
ENSG00000175354 E002 0.4730484 0.0158866210 7.113618e-02   18 12785481 12785482 2 - 0.274 0.000 -13.488
ENSG00000175354 E003 0.4730484 0.0158866210 7.113618e-02   18 12785483 12785505 23 - 0.274 0.000 -13.488
ENSG00000175354 E004 1.0721580 0.0110653701 2.941775e-02 1.611472e-01 18 12785506 12785533 28 - 0.441 0.105 -2.693
ENSG00000175354 E005 17.7824088 0.0200510071 7.090311e-01 8.821885e-01 18 12785534 12785684 151 - 1.285 1.259 -0.090
ENSG00000175354 E006 37.0074819 0.0004191895 6.533209e-01 8.542733e-01 18 12785685 12785844 160 - 1.567 1.592 0.088
ENSG00000175354 E007 41.2771140 0.0031440360 6.996913e-14 1.063018e-11 18 12785845 12787741 1897 - 1.409 1.787 1.288
ENSG00000175354 E008 2.3761642 0.0059389358 2.694161e-03 3.183762e-02 18 12788065 12788150 86 - 0.274 0.706 2.214
ENSG00000175354 E009 1.0909141 0.0121113327 4.828916e-01 7.476733e-01 18 12792152 12792301 150 - 0.366 0.259 -0.693
ENSG00000175354 E010 12.0451902 0.0252090030 7.398754e-02 2.771142e-01 18 12792302 12793481 1180 - 1.019 1.203 0.663
ENSG00000175354 E011 3.4297791 0.0045710535 5.959661e-01 8.224249e-01 18 12793482 12793574 93 - 0.611 0.682 0.307
ENSG00000175354 E012 4.3888319 0.0095071236 9.508957e-01 9.875478e-01 18 12793575 12793834 260 - 0.732 0.729 -0.015
ENSG00000175354 E013 7.2751461 0.0106961470 2.164310e-01 5.025180e-01 18 12793835 12794111 277 - 0.971 0.844 -0.481
ENSG00000175354 E014 11.4039505 0.0012448251 1.285127e-01 3.801461e-01 18 12794112 12794383 272 - 1.146 1.022 -0.446
ENSG00000175354 E015 28.3080802 0.0005092479 4.489774e-02 2.071217e-01 18 12794384 12794485 102 - 1.511 1.407 -0.361
ENSG00000175354 E016 14.2302051 0.0012944913 2.163998e-01 5.025180e-01 18 12801970 12801988 19 - 1.221 1.131 -0.319
ENSG00000175354 E017 33.0601641 0.0006284840 4.027564e-02 1.945742e-01 18 12801989 12802151 163 - 1.574 1.475 -0.340
ENSG00000175354 E018 0.0000000       18 12802152 12802153 2 -      
ENSG00000175354 E019 0.0000000       18 12814197 12814202 6 -      
ENSG00000175354 E020 24.6171244 0.0006790084 6.827979e-01 8.685848e-01 18 12814203 12814324 122 - 1.416 1.397 -0.066
ENSG00000175354 E021 14.8607327 0.0009340198 6.000988e-01 8.247937e-01 18 12814325 12814355 31 - 1.215 1.181 -0.121
ENSG00000175354 E022 12.5144039 0.0011311213 2.072927e-01 4.909516e-01 18 12817156 12817180 25 - 1.172 1.075 -0.348
ENSG00000175354 E023 20.3533737 0.0007015900 6.254472e-01 8.389012e-01 18 12817181 12817265 85 - 1.341 1.314 -0.093
ENSG00000175354 E024 20.8205964 0.0007031719 3.582403e-01 6.477148e-01 18 12817266 12817365 100 - 1.362 1.308 -0.187
ENSG00000175354 E025 1.3748034 0.2213044395 6.828016e-02 2.637415e-01 18 12818944 12819213 270 - 0.158 0.538 2.477
ENSG00000175354 E026 1.1047621 0.0811763578 5.727010e-01 8.085071e-01 18 12819214 12819282 69 - 0.274 0.373 0.629
ENSG00000175354 E027 0.6046553 0.3781001467 9.927149e-01 1.000000e+00 18 12821336 12821425 90 - 0.220 0.189 -0.275
ENSG00000175354 E028 0.0000000       18 12825804 12825809 6 -      
ENSG00000175354 E029 18.4448593 0.0008198578 4.058234e-02 1.954082e-01 18 12825810 12825944 135 - 1.345 1.211 -0.470
ENSG00000175354 E030 13.2921039 0.0014858551 6.978713e-01 8.766924e-01 18 12830943 12831041 99 - 1.166 1.140 -0.092
ENSG00000175354 E031 7.8436590 0.0444122028 3.946228e-01 6.794224e-01 18 12836791 12836823 33 - 0.893 0.999 0.398
ENSG00000175354 E032 12.4536039 0.0093998144 8.455970e-01 9.450825e-01 18 12836824 12836891 68 - 1.117 1.140 0.081
ENSG00000175354 E033 0.2356421 0.0156465200 3.196729e-01   18 12839502 12839557 56 - 0.158 0.000 -12.589
ENSG00000175354 E034 0.3715287 0.2293459350 5.199489e-01   18 12840714 12840962 249 - 0.086 0.189 1.308
ENSG00000175354 E035 0.0000000       18 12843905 12843981 77 -      
ENSG00000175354 E036 9.2479544 0.0014739954 4.628190e-01 7.329899e-01 18 12859164 12859254 91 - 1.037 0.975 -0.230
ENSG00000175354 E037 0.3812526 0.0158517659 6.977206e-02   18 12860472 12860525 54 - 0.000 0.259 12.958
ENSG00000175354 E038 0.3635961 0.0166507469 7.162541e-01   18 12862084 12862639 556 - 0.158 0.105 -0.693
ENSG00000175354 E039 0.2448930 0.0164734539 8.753085e-01   18 12862640 12862716 77 - 0.086 0.105 0.307
ENSG00000175354 E040 0.0000000       18 12862717 12862744 28 -      
ENSG00000175354 E041 0.1265070 0.0123802986 4.387912e-01   18 12863197 12864194 998 - 0.000 0.105 11.479
ENSG00000175354 E042 0.2459004 0.0164047645 8.745010e-01   18 12869025 12869122 98 - 0.086 0.105 0.307
ENSG00000175354 E043 0.2459004 0.0164047645 8.745010e-01   18 12872228 12872269 42 - 0.086 0.105 0.307
ENSG00000175354 E044 0.1187032 0.0118406916 6.570475e-01   18 12880496 12880692 197 - 0.086 0.000 -11.655
ENSG00000175354 E045 0.1170040 0.0117893590 6.569664e-01   18 12883618 12884072 455 - 0.086 0.000 -11.655
ENSG00000175354 E046 8.1453726 0.0018212883 3.102385e-01 6.034733e-01 18 12884073 12884338 266 - 1.001 0.907 -0.350
ENSG00000175354 E047 0.0000000       18 12929499 12929643 145 -      

Help

Please Click HERE to learn more details about the results from DEXseq.