ENSG00000177666

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000336615 ENSG00000177666 No_inf pgKDN_inf PNPLA2 protein_coding protein_coding 59.76076 86.9638 38.79167 0.67176 2.922051 -1.164462 32.919728 37.440622 30.017853 0.5039886 0.7748796 -0.3186884 0.60492500 0.430650 0.783775 0.353125 5.509036e-06 5.509036e-06 FALSE TRUE
ENST00000526083 ENSG00000177666 No_inf pgKDN_inf PNPLA2 protein_coding retained_intron 59.76076 86.9638 38.79167 0.67176 2.922051 -1.164462 13.777854 26.317386 2.691800 1.3495227 2.6918005 -3.2845712 0.19052500 0.302350 0.057450 -0.244900 9.537004e-03 5.509036e-06   FALSE
ENST00000534561 ENSG00000177666 No_inf pgKDN_inf PNPLA2 protein_coding retained_intron 59.76076 86.9638 38.79167 0.67176 2.922051 -1.164462 3.398018 5.513002 1.388201 0.6426662 0.6989773 -1.9818805 0.05393333 0.063500 0.035100 -0.028400 6.355132e-01 5.509036e-06 FALSE FALSE
MSTRG.4218.2 ENSG00000177666 No_inf pgKDN_inf PNPLA2 protein_coding   59.76076 86.9638 38.79167 0.67176 2.922051 -1.164462 5.090960 9.105508 1.889203 0.3342778 0.3346430 -2.2629291 0.07813333 0.104725 0.049175 -0.055550 2.880955e-01 5.509036e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000177666 E001 0.1186381 0.0118751751 2.725379e-01   11 818914 818958 45 + 0.126 0.000 -9.129
ENSG00000177666 E002 33.3177818 0.0006979464 9.308365e-04 1.420592e-02 11 819574 819905 332 + 1.617 1.446 -0.586
ENSG00000177666 E003 27.7624213 0.0005112463 2.569863e-11 2.766527e-09 11 819999 820834 836 + 1.083 1.538 1.593
ENSG00000177666 E004 29.8505194 0.0004716141 5.090431e-10 4.606498e-08 11 820835 821627 793 + 1.160 1.559 1.390
ENSG00000177666 E005 50.0615891 0.0003078207 2.492711e-01 5.401597e-01 11 821628 821773 146 + 1.714 1.665 -0.167
ENSG00000177666 E006 37.5145824 0.0031306267 9.949662e-01 1.000000e+00 11 821774 821860 87 + 1.560 1.559 -0.002
ENSG00000177666 E007 35.0922852 0.0004657515 4.047260e-01 6.874249e-01 11 821958 822015 58 + 1.560 1.517 -0.148
ENSG00000177666 E008 24.2474048 0.0009422243 2.925319e-02 1.605027e-01 11 822016 822023 8 + 1.461 1.328 -0.459
ENSG00000177666 E009 9.1285539 0.0015033496 8.463681e-03 7.182286e-02 11 822024 822396 373 + 0.781 1.054 1.034
ENSG00000177666 E010 83.7059391 0.0001840205 1.998234e-02 1.269403e-01 11 822397 822606 210 + 1.950 1.876 -0.250
ENSG00000177666 E011 16.3888241 0.0257674239 2.505529e-01 5.417042e-01 11 823527 823542 16 + 1.290 1.173 -0.413
ENSG00000177666 E012 11.7071905 0.0261405162 3.143199e-01 6.073998e-01 11 823543 823587 45 + 1.150 1.040 -0.395
ENSG00000177666 E013 1.6127052 0.2355658559 6.844591e-01 8.693877e-01 11 823588 823647 60 + 0.370 0.415 0.253
ENSG00000177666 E014 0.0000000       11 823648 823693 46 +      
ENSG00000177666 E015 0.0000000       11 823694 823855 162 +      
ENSG00000177666 E016 3.1192190 0.0043823720 2.537074e-01 5.452402e-01 11 823856 823997 142 + 0.480 0.642 0.746
ENSG00000177666 E017 44.5733859 0.0012672095 1.385525e-01 3.958621e-01 11 823998 824130 133 + 1.584 1.655 0.243
ENSG00000177666 E018 25.7928363 0.0007335129 7.789436e-03 6.785906e-02 11 824314 824421 108 + 1.282 1.451 0.585
ENSG00000177666 E019 0.0000000       11 824422 824436 15 +      
ENSG00000177666 E020 0.0000000       11 824437 824437 1 +      
ENSG00000177666 E021 0.0000000       11 824523 824535 13 +      
ENSG00000177666 E022 141.1529432 0.0001606091 3.862746e-02 1.901198e-01 11 824536 825573 1038 + 2.158 2.110 -0.163

Help

Please Click HERE to learn more details about the results from DEXseq.