ENSG00000180370

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000327134 ENSG00000180370 No_inf pgKDN_inf PAK2 protein_coding protein_coding 49.16364 49.38193 55.70977 0.7752685 0.9333182 0.173914 37.367381 28.49666 44.770882 1.298554 1.590431 0.6515839 0.7665583 0.578375 0.80365 0.225275 0.00184893 0.00184893 FALSE TRUE
ENST00000426668 ENSG00000180370 No_inf pgKDN_inf PAK2 protein_coding protein_coding 49.16364 49.38193 55.70977 0.7752685 0.9333182 0.173914 8.481696 14.37712 9.159308 1.118789 1.735811 -0.6498932 0.1672917 0.291825 0.16460 -0.127225 0.28045828 0.00184893 FALSE TRUE
MSTRG.21347.4 ENSG00000180370 No_inf pgKDN_inf PAK2 protein_coding   49.16364 49.38193 55.70977 0.7752685 0.9333182 0.173914 3.314561 6.50815 1.779583 2.190628 1.779583 -1.8648390 0.0661500 0.129800 0.03175 -0.098050 0.26179527 0.00184893 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000180370 E001 17.9883547 0.0068149256 0.0604245702 0.2466570317 3 196739857 196740157 301 + 1.333 1.213 -0.422
ENSG00000180370 E002 36.6740598 0.0004242943 0.0004761577 0.0084007495 3 196782626 196782833 208 + 1.643 1.493 -0.510
ENSG00000180370 E003 18.4971648 0.0007327307 0.0860816021 0.3039029343 3 196801927 196802027 101 + 1.333 1.240 -0.327
ENSG00000180370 E004 39.0121330 0.0004440820 0.1476704483 0.4091050933 3 196803017 196803164 148 + 1.624 1.578 -0.155
ENSG00000180370 E005 16.4958240 0.0008167185 0.6825418131 0.8685848222 3 196805352 196805383 32 + 1.246 1.240 -0.022
ENSG00000180370 E006 32.4595473 0.0004398539 0.3373373075 0.6290913296 3 196806579 196806686 108 + 1.537 1.511 -0.090
ENSG00000180370 E007 45.6214602 0.0018952827 0.2025160182 0.4849271411 3 196807782 196807914 133 + 1.686 1.650 -0.123
ENSG00000180370 E008 0.0000000       3 196807915 196808044 130 +      
ENSG00000180370 E009 26.7380286 0.0157206931 0.4827683384 0.7476733211 3 196810590 196810653 64 + 1.458 1.427 -0.107
ENSG00000180370 E010 0.2530140 0.2196405698 0.2683631219   3 196812218 196812218 1 + 0.000 0.182 9.612
ENSG00000180370 E011 23.7131895 0.0008725923 0.0280541824 0.1565171518 3 196812219 196812267 49 + 1.443 1.333 -0.383
ENSG00000180370 E012 0.4988535 0.0215698086 0.2921057190   3 196812694 196812738 45 + 0.090 0.250 1.756
ENSG00000180370 E013 45.4077354 0.0003197207 0.0139320357 0.0996962207 3 196812739 196812851 113 + 1.706 1.621 -0.289
ENSG00000180370 E014 52.2149906 0.0003583113 0.1671807057 0.4377139256 3 196814451 196814568 118 + 1.742 1.709 -0.113
ENSG00000180370 E015 50.2592679 0.0005343198 0.9926790687 1.0000000000 3 196818057 196818156 100 + 1.698 1.722 0.080
ENSG00000180370 E016 22.2635260 0.0009083325 0.9805446874 0.9978433022 3 196820371 196820393 23 + 1.356 1.378 0.076
ENSG00000180370 E017 60.4333030 0.0029159465 0.3492194910 0.6395992970 3 196820394 196820567 174 + 1.796 1.780 -0.057
ENSG00000180370 E018 49.0767271 0.0003076498 0.2835109027 0.5772538422 3 196827196 196827333 138 + 1.710 1.688 -0.074
ENSG00000180370 E019 1083.5887057 0.0016639437 0.0000211851 0.0006462397 3 196828319 196832647 4329 + 3.006 3.064 0.193

Help

Please Click HERE to learn more details about the results from DEXseq.