ENSG00000186575

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000338641 ENSG00000186575 No_inf pgKDN_inf NF2 protein_coding protein_coding 16.48742 13.84741 17.53861 0.2971298 1.099051 0.340699 2.437325 0.000000 3.669618 0.0000000 1.394022 8.5234121 0.1418333 0.0000 0.223800 0.223800 0.03827400 0.02668639 FALSE TRUE
ENST00000672461 ENSG00000186575 No_inf pgKDN_inf NF2 protein_coding nonsense_mediated_decay 16.48742 13.84741 17.53861 0.2971298 1.099051 0.340699 5.274669 3.943068 6.418798 0.2088487 1.088588 0.7015762 0.3167583 0.2849 0.361300 0.076400 0.82741627 0.02668639 TRUE TRUE
MSTRG.19236.16 ENSG00000186575 No_inf pgKDN_inf NF2 protein_coding   16.48742 13.84741 17.53861 0.2971298 1.099051 0.340699 7.734751 9.475115 6.529519 0.2906410 1.358689 -0.5364806 0.4829083 0.6846 0.364475 -0.320125 0.02668639 0.02668639 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000186575 E001 0.1170040 0.0117136625 6.477505e-01   22 29603556 29603567 12 + 0.088 0.000 -9.070
ENSG00000186575 E002 0.1170040 0.0117136625 6.477505e-01   22 29603568 29603587 20 + 0.088 0.000 -11.357
ENSG00000186575 E003 0.1170040 0.0117136625 6.477505e-01   22 29603588 29603602 15 + 0.088 0.000 -11.357
ENSG00000186575 E004 0.2356421 0.0156368614 3.133575e-01   22 29603603 29603616 14 + 0.161 0.000 -12.277
ENSG00000186575 E005 0.3526461 0.0324528712 1.470184e-01   22 29603617 29603632 16 + 0.223 0.000 -12.731
ENSG00000186575 E006 2.2866542 0.0060418589 9.151017e-02 0.3141259576 22 29603633 29603726 94 + 0.616 0.369 -1.228
ENSG00000186575 E007 1.9412503 0.0092445378 5.351829e-01 0.7850027875 22 29603727 29603746 20 + 0.510 0.416 -0.480
ENSG00000186575 E008 5.5845142 0.0484772601 3.722055e-01 0.6600642437 22 29603747 29603948 202 + 0.875 0.744 -0.514
ENSG00000186575 E009 4.1466888 0.0913469683 8.107406e-01 0.9303506722 22 29603949 29603998 50 + 0.720 0.700 -0.083
ENSG00000186575 E010 5.6967778 0.0062981266 2.158755e-01 0.5018115210 22 29603999 29604085 87 + 0.887 0.744 -0.562
ENSG00000186575 E011 3.2380733 0.1836414356 6.626249e-02 0.2591964883 22 29604086 29604112 27 + 0.756 0.416 -1.551
ENSG00000186575 E012 0.0000000       22 29628658 29628773 116 +      
ENSG00000186575 E013 6.5572599 0.0322284499 4.072243e-01 0.6897350739 22 29636751 29636876 126 + 0.924 0.821 -0.395
ENSG00000186575 E014 5.3132534 0.0026991752 7.017598e-02 0.2680997321 22 29639090 29639212 123 + 0.887 0.676 -0.842
ENSG00000186575 E015 5.1622637 0.0034243010 2.977023e-03 0.0343659381 22 29642202 29642285 84 + 0.924 0.565 -1.465
ENSG00000186575 E016 4.8971233 0.0061203032 1.844845e-04 0.0039127301 22 29654657 29654725 69 + 0.935 0.458 -2.023
ENSG00000186575 E017 0.0000000       22 29654975 29655080 106 +      
ENSG00000186575 E018 6.7089716 0.0084739210 3.670330e-04 0.0068428947 22 29655594 29655676 83 + 1.035 0.624 -1.617
ENSG00000186575 E019 7.1733338 0.0056510038 1.880032e-05 0.0005847616 22 29658189 29658264 76 + 1.078 0.596 -1.898
ENSG00000186575 E020 1.5040155 0.0093625329 7.006958e-03 0.0630696418 22 29658521 29658586 66 + 0.161 0.565 2.579
ENSG00000186575 E021 13.8708931 0.0010553686 5.359113e-04 0.0092197262 22 29661205 29661339 135 + 1.282 1.004 -0.995
ENSG00000186575 E022 8.3906044 0.0017075869 4.307552e-01 0.7085511084 22 29664990 29665064 75 + 1.008 0.929 -0.293
ENSG00000186575 E023 12.4582700 0.0066248097 8.790345e-01 0.9590728087 22 29668333 29668446 114 + 1.124 1.133 0.031
ENSG00000186575 E024 11.7791689 0.0012015591 1.838054e-01 0.4607983642 22 29671826 29671912 87 + 1.053 1.158 0.378
ENSG00000186575 E025 9.7268972 0.0017009315 3.902682e-02 0.1912824902 22 29671913 29671948 36 + 0.935 1.115 0.662
ENSG00000186575 E026 25.3811950 0.0107555460 9.492009e-01 0.9867620019 22 29673269 29673486 218 + 1.424 1.418 -0.021
ENSG00000186575 E027 18.0505685 0.0316662142 8.569012e-01 0.9497888137 22 29674836 29674941 106 + 1.287 1.271 -0.056
ENSG00000186575 E028 22.1290511 0.0006453570 5.479256e-01 0.7932370644 22 29678196 29678323 128 + 1.348 1.380 0.114
ENSG00000186575 E029 18.8231476 0.0079355687 7.480094e-01 0.9005751771 22 29681439 29681601 163 + 1.287 1.307 0.070
ENSG00000186575 E030 1.7264706 0.0079183160 3.805644e-01 0.6670660752 22 29683020 29683064 45 + 0.370 0.497 0.672
ENSG00000186575 E031 0.8711647 0.0124012933 1.661318e-01 0.4362293912 22 29683065 29683079 15 + 0.161 0.369 1.579
ENSG00000186575 E032 1.4868310 0.0088275455 1.406551e-01 0.3989607678 22 29683080 29683700 621 + 0.278 0.497 1.258
ENSG00000186575 E033 0.2536433 0.0159905188 1.844961e-01   22 29683701 29684162 462 + 0.000 0.186 11.598
ENSG00000186575 E034 26.7180148 0.0035698362 6.791914e-01 0.8674285524 22 29694752 29695243 492 + 1.455 1.426 -0.100
ENSG00000186575 E035 92.9487373 0.0006098445 1.250510e-01 0.3749143263 22 29695244 29697260 2017 + 1.953 1.993 0.136
ENSG00000186575 E036 127.0411462 0.0002070245 7.175089e-05 0.0017949038 22 29697261 29698634 1374 + 2.063 2.151 0.294

Help

Please Click HERE to learn more details about the results from DEXseq.