ENSG00000186591

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355621 ENSG00000186591 No_inf pgKDN_inf UBE2H protein_coding protein_coding 24.43069 23.11307 27.83884 1.787765 3.152272 0.2682842 15.805981 11.783836 20.040954 2.787348 0.3468123 0.7656379 0.6499167 0.49650 0.7468 0.25030 0.319019396 0.007771487 FALSE TRUE
ENST00000496698 ENSG00000186591 No_inf pgKDN_inf UBE2H protein_coding protein_coding 24.43069 23.11307 27.83884 1.787765 3.152272 0.2682842 3.263680 1.901888 5.261525 1.901888 3.3889294 1.4632222 0.1110583 0.06810 0.1590 0.09090 0.806300855 0.007771487 FALSE FALSE
ENST00000649897 ENSG00000186591 No_inf pgKDN_inf UBE2H protein_coding protein_coding 24.43069 23.11307 27.83884 1.787765 3.152272 0.2682842 2.963907 8.056586 0.000000 2.800067 0.0000000 -9.6558144 0.1367167 0.37455 0.0000 -0.37455 0.007771487 0.007771487 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000186591 E001 0.5998373 0.0150696198 1.676824e-01 4.384227e-01 7 129830732 129830743 12 - 0.298 0.094 -2.023
ENSG00000186591 E002 429.0802950 0.0001176041 2.027552e-09 1.629717e-07 7 129830744 129834936 4193 - 2.606 2.657 0.169
ENSG00000186591 E003 9.0947797 0.0043747308 2.788194e-02 1.558972e-01 7 129834937 129834940 4 - 1.100 0.892 -0.770
ENSG00000186591 E004 13.0009718 0.0012581791 2.150675e-02 1.328384e-01 7 129834941 129834977 37 - 1.231 1.049 -0.653
ENSG00000186591 E005 23.6231755 0.0007080325 3.325516e-02 1.733567e-01 7 129834978 129835061 84 - 1.453 1.325 -0.442
ENSG00000186591 E006 0.0000000       7 129839204 129839206 3 -      
ENSG00000186591 E007 17.1448748 0.0075088446 4.634144e-02 2.111497e-01 7 129839207 129839224 18 - 1.332 1.179 -0.540
ENSG00000186591 E008 22.1406532 0.0043294583 3.010164e-02 1.632152e-01 7 129839225 129839275 51 - 1.434 1.289 -0.503
ENSG00000186591 E009 19.9467883 0.0006778708 7.363225e-01 8.953403e-01 7 129839276 129839335 60 - 1.332 1.310 -0.076
ENSG00000186591 E010 0.8610026 0.0697060027 7.445090e-01 8.987986e-01 7 129839336 129839741 406 - 0.241 0.295 0.392
ENSG00000186591 E011 0.1268540 0.0123221400 5.468679e-01   7 129856973 129857078 106 - 0.000 0.094 10.137
ENSG00000186591 E012 0.9708253 0.0441063209 4.843007e-01 7.484747e-01 7 129857079 129857510 432 - 0.349 0.238 -0.760
ENSG00000186591 E013 12.4245513 0.0012405786 2.263660e-01 5.144239e-01 7 129857511 129857547 37 - 1.074 1.171 0.350
ENSG00000186591 E014 7.2490602 0.0060173171 5.692343e-01 8.062764e-01 7 129857548 129857563 16 - 0.884 0.943 0.222
ENSG00000186591 E015 14.7972991 0.0010118047 5.886348e-01 8.175137e-01 7 129858902 129858941 40 - 1.219 1.178 -0.142
ENSG00000186591 E016 0.0000000       7 129858942 129858969 28 -      
ENSG00000186591 E017 0.1187032 0.0119230566 5.295355e-01   7 129865015 129865065 51 - 0.096 0.000 -11.170
ENSG00000186591 E018 20.2498237 0.0006484529 1.322553e-01 3.860089e-01 7 129879568 129879642 75 - 1.375 1.278 -0.337
ENSG00000186591 E019 0.0000000       7 129880879 129880894 16 -      
ENSG00000186591 E020 16.7098846 0.0013644144 1.728176e-01 4.457586e-01 7 129880895 129880971 77 - 1.296 1.199 -0.340
ENSG00000186591 E021 0.0000000       7 129880972 129880976 5 -      
ENSG00000186591 E022 0.0000000       7 129924880 129924943 64 -      
ENSG00000186591 E023 0.0000000       7 129925528 129925549 22 -      
ENSG00000186591 E024 0.0000000       7 129937708 129937732 25 -      
ENSG00000186591 E025 0.1186381 0.0118260137 5.296813e-01   7 129948959 129949102 144 - 0.096 0.000 -11.171
ENSG00000186591 E026 0.1272623 0.0123322364 5.469329e-01   7 129951278 129951327 50 - 0.000 0.094 10.137
ENSG00000186591 E027 26.0310733 0.0011562637 4.493610e-03 4.599138e-02 7 129952503 129952960 458 - 1.510 1.345 -0.569

Help

Please Click HERE to learn more details about the results from DEXseq.