ENSG00000197046

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000389474 ENSG00000197046 No_inf pgKDN_inf SIGLEC15 protein_coding protein_coding 38.09269 49.61421 27.28412 18.74411 0.9701855 -0.8624542 18.9599275 2.456787 23.234161 0.4558866 1.2441273 3.236163 0.638750 0.222600 0.850225 0.627625 0.0004139451 0.0004139451 FALSE TRUE
MSTRG.13889.1 ENSG00000197046 No_inf pgKDN_inf SIGLEC15 protein_coding   38.09269 49.61421 27.28412 18.74411 0.9701855 -0.8624542 0.9152589 0.000000 1.494093 0.0000000 0.3903177 7.232750 0.029300 0.000000 0.054800 0.054800 0.0010267456 0.0004139451 FALSE TRUE
MSTRG.13889.6 ENSG00000197046 No_inf pgKDN_inf SIGLEC15 protein_coding   38.09269 49.61421 27.28412 18.74411 0.9701855 -0.8624542 15.3475545 46.042663 0.000000 18.7558308 0.0000000 -12.169069 0.234775 0.704325 0.000000 -0.704325 0.0115332749 0.0004139451   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000197046 E001 0.8253137 0.0124131001 5.178271e-01 0.77325672 18 45825565 45825674 110 + 0.216 0.000 -10.049
ENSG00000197046 E002 6.6350275 0.0038113106 7.161749e-02 0.27121315 18 45825675 45825780 106 + 0.768 0.471 -1.314
ENSG00000197046 E003 0.3727544 0.0167600256 2.445932e-02   18 45829088 45829090 3 + 0.038 0.363 3.828
ENSG00000197046 E004 0.8543620 0.0153039719 4.679919e-02 0.21242418 18 45829091 45829183 93 + 0.136 0.471 2.413
ENSG00000197046 E005 0.5071304 0.0158506922 9.710774e-05 0.00231526 18 45835231 45835281 51 + 0.000 0.557 14.395
ENSG00000197046 E006 10.4692045 0.0013359475 7.388072e-01 0.89640123 18 45837029 45837088 60 + 0.912 0.876 -0.135
ENSG00000197046 E007 25.3466171 0.0005820988 7.204847e-01 0.88744162 18 45837513 45837840 328 + 1.262 1.238 -0.082
ENSG00000197046 E008 6.9441388 0.0020581735 1.594547e-01 0.42687193 18 45837841 45837885 45 + 0.726 0.913 0.733
ENSG00000197046 E009 3.6105675 0.0040983660 3.713653e-02 0.18555880 18 45837886 45837896 11 + 0.480 0.794 1.369
ENSG00000197046 E010 0.8338078 0.0136957277 9.273348e-01 0.97838175 18 45838522 45838717 196 + 0.191 0.218 0.244
ENSG00000197046 E011 27.6372909 0.0005286044 8.384330e-01 0.94210680 18 45838718 45839095 378 + 1.291 1.313 0.077
ENSG00000197046 E012 9.5268415 0.0016433899 9.995663e-01 1.00000000 18 45840211 45840241 31 + 0.871 0.876 0.021
ENSG00000197046 E013 0.6154789 0.0176557543 1.205357e-02 0.09079567 18 45840886 45841094 209 + 0.073 0.471 3.414
ENSG00000197046 E014 171.5757003 0.0001856736 1.388889e-01 0.39629859 18 45842106 45844551 2446 + 2.071 2.046 -0.084

Help

Please Click HERE to learn more details about the results from DEXseq.