ENSG00000198517

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000343242 ENSG00000198517 No_inf pgKDN_inf MAFK protein_coding protein_coding 21.41149 17.81933 22.40112 0.2303014 0.1331398 0.3299617 18.499847 14.053731 21.5642209 0.8646565 0.2571818 0.6173291 0.86027500 0.787200 0.962625 0.175425 0.0006551849 0.0006551849 FALSE TRUE
ENST00000403150 ENSG00000198517 No_inf pgKDN_inf MAFK protein_coding nonsense_mediated_decay 21.41149 17.81933 22.40112 0.2303014 0.1331398 0.3299617 1.047160 1.876212 0.6195286 0.5719158 0.2924296 -1.5831479 0.05310833 0.104175 0.027625 -0.076550 0.4097162853 0.0006551849 TRUE TRUE
MSTRG.25733.4 ENSG00000198517 No_inf pgKDN_inf MAFK protein_coding   21.41149 17.81933 22.40112 0.2303014 0.1331398 0.3299617 1.021873 1.889391 0.2173667 1.1729508 0.2173667 -3.0624439 0.05237500 0.108650 0.009750 -0.098900 0.7396229009 0.0006551849 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000198517 E001 0.6088971 0.0158876069 7.348387e-01 8.948191e-01 7 1530702 1530756 55 + 0.229 0.181 -0.428
ENSG00000198517 E002 8.2655575 0.0017865796 1.880865e-01 4.663382e-01 7 1530757 1530898 142 + 1.021 0.902 -0.446
ENSG00000198517 E003 2.6273530 0.0056586457 1.753720e-03 2.306392e-02 7 1537487 1537757 271 + 0.285 0.732 2.244
ENSG00000198517 E004 9.5367447 0.0051674136 4.335482e-10 3.969947e-08 7 1537758 1538457 700 + 0.604 1.238 2.434
ENSG00000198517 E005 0.5074773 0.0161828261 3.576513e-02 1.813952e-01 7 1538708 1538826 119 + 0.000 0.308 10.594
ENSG00000198517 E006 10.6513330 0.0132381176 6.154866e-01 8.331406e-01 7 1539149 1539228 80 + 1.040 1.092 0.190
ENSG00000198517 E007 111.3113567 0.0001675524 4.757128e-01 7.423589e-01 7 1539941 1541274 1334 + 2.055 2.046 -0.030
ENSG00000198517 E008 81.4289971 0.0002209936 1.622966e-02 1.107033e-01 7 1541275 1542298 1024 + 1.944 1.885 -0.199
ENSG00000198517 E009 0.0000000       7 1542299 1543043 745 +      

Help

Please Click HERE to learn more details about the results from DEXseq.