ENSG00000213593

Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000278422 ENSG00000213593 No_inf pgKDN_inf TMX2 protein_coding protein_coding 120.6095 69.34125 144.0133 1.187195 0.5263159 1.054308 81.253647 42.096762 94.066036 1.0108114 4.3614072 1.159775 0.66172500 0.607225 0.653375 0.04615 0.779811731 0.004207557 FALSE  
ENST00000378312 ENSG00000213593 No_inf pgKDN_inf TMX2 protein_coding protein_coding 120.6095 69.34125 144.0133 1.187195 0.5263159 1.054308 31.409059 17.986455 44.051838 0.6283591 4.5062265 1.291817 0.26080833 0.259350 0.305750 0.04640 0.806300855 0.004207557 FALSE  
ENST00000524972 ENSG00000213593 No_inf pgKDN_inf TMX2 protein_coding nonsense_mediated_decay 120.6095 69.34125 144.0133 1.187195 0.5263159 1.054308 3.364047 4.726771 1.538616 0.2209724 0.4461179 -1.612924 0.03479167 0.068275 0.010675 -0.05760 0.004207557 0.004207557 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results from IsoformSwitchAnalyzeR.