ENSG00000227057

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000374617 ENSG00000227057 No_inf pgKDN_inf WDR46 protein_coding protein_coding 52.31042 43.82373 55.91614 1.133014 2.274389 0.3514813 37.492778 26.09175 44.949928 0.7667101 0.364565 0.7844931 0.7111 0.597125 0.80780 0.210675 0.007827669 0.007827669 FALSE TRUE
MSTRG.24538.5 ENSG00000227057 No_inf pgKDN_inf WDR46 protein_coding   52.31042 43.82373 55.91614 1.133014 2.274389 0.3514813 6.313043 8.05391 3.635624 1.5048686 0.825357 -1.1453139 0.1242 0.182000 0.06395 -0.118050 0.140677936 0.007827669 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000227057 E001 0.4828984 0.0264226298 0.4581707301   6 33279108 33279117 10 - 0.216 0.107 -1.210
ENSG00000227057 E002 44.1080662 0.0003448023 0.2699090022 0.563536394 6 33279118 33279374 257 - 1.628 1.680 0.175
ENSG00000227057 E003 1.9473238 0.0081529392 0.9963248522 1.000000000 6 33279375 33279496 122 - 0.467 0.470 0.013
ENSG00000227057 E004 33.2961583 0.0004273753 0.8345874445 0.940368923 6 33279497 33279570 74 - 1.527 1.541 0.046
ENSG00000227057 E005 23.5759267 0.0005756055 0.2563131425 0.548375304 6 33279571 33279610 40 - 1.417 1.351 -0.228
ENSG00000227057 E006 40.1780885 0.0003709389 0.3544627522 0.644224648 6 33279764 33279859 96 - 1.592 1.637 0.156
ENSG00000227057 E007 33.8875311 0.0070384765 0.1932517614 0.473098838 6 33280428 33280522 95 - 1.502 1.584 0.281
ENSG00000227057 E008 9.9398092 0.0260435530 0.0001039265 0.002449812 6 33280523 33280673 151 - 0.789 1.220 1.598
ENSG00000227057 E009 28.5751988 0.0005200566 0.4473874283 0.721508045 6 33280674 33280814 141 - 1.448 1.493 0.153
ENSG00000227057 E010 28.8508397 0.0006376455 0.4618527402 0.732397333 6 33280815 33280915 101 - 1.490 1.452 -0.129
ENSG00000227057 E011 31.2470123 0.0004753487 0.2900373811 0.583654214 6 33280916 33280987 72 - 1.530 1.477 -0.182
ENSG00000227057 E012 0.1271363 0.0123109869 0.4163005436   6 33284272 33284329 58 - 0.000 0.107 11.077
ENSG00000227057 E013 0.1271363 0.0123109869 0.4163005436   6 33284330 33284390 61 - 0.000 0.107 11.077
ENSG00000227057 E014 32.2701059 0.0004531527 0.1841693195 0.461269995 6 33286795 33286894 100 - 1.487 1.558 0.244
ENSG00000227057 E015 41.4332627 0.0007325493 0.9501854154 0.987130329 6 33287091 33287226 136 - 1.626 1.626 0.000
ENSG00000227057 E016 0.0000000       6 33287227 33287242 16 -      
ENSG00000227057 E017 0.0000000       6 33287243 33287354 112 -      
ENSG00000227057 E018 49.0608300 0.0003000072 0.5168646019 0.772537619 6 33287355 33287491 137 - 1.684 1.714 0.102
ENSG00000227057 E019 23.0337831 0.0006707624 0.9294432539 0.979257667 6 33287492 33287505 14 - 1.380 1.378 -0.009
ENSG00000227057 E020 0.3726934 0.0165503640 0.4387541204   6 33287506 33287591 86 - 0.085 0.192 1.375
ENSG00000227057 E021 1.1174162 0.0123154578 0.1712803590 0.443657424 6 33287592 33287613 22 - 0.216 0.427 1.375
ENSG00000227057 E022 33.6711915 0.0004011770 0.7704113706 0.911502898 6 33287614 33287663 50 - 1.530 1.548 0.060
ENSG00000227057 E023 26.5904423 0.0065094898 0.8370049554 0.941568605 6 33287664 33287718 55 - 1.431 1.448 0.056
ENSG00000227057 E024 23.2171461 0.0049032729 0.3167534701 0.609612534 6 33287965 33288002 38 - 1.410 1.346 -0.222
ENSG00000227057 E025 21.8649085 0.0016185379 0.2571391306 0.549452326 6 33288003 33288026 24 - 1.388 1.318 -0.243
ENSG00000227057 E026 1.2303624 0.0832445425 0.3413720889 0.632945496 6 33288056 33288147 92 - 0.269 0.427 0.961
ENSG00000227057 E027 32.6015596 0.0006048795 0.3768261133 0.663979209 6 33288148 33288235 88 - 1.544 1.501 -0.147
ENSG00000227057 E028 2.0846783 0.3585961227 0.3949962097 0.679783196 6 33288236 33288357 122 - 0.434 0.545 0.546
ENSG00000227057 E029 34.0232560 0.0044908547 0.2619494880 0.554710500 6 33288358 33288470 113 - 1.569 1.508 -0.210
ENSG00000227057 E030 0.6347396 0.0150691597 0.0096697451 0.078627466 6 33288564 33288613 50 - 0.000 0.379 13.399
ENSG00000227057 E031 28.3740691 0.0005401954 0.0415609908 0.198191908 6 33288614 33288694 81 - 1.513 1.402 -0.381
ENSG00000227057 E032 51.7266340 0.0002922653 0.3282833141 0.620771063 6 33288804 33289013 210 - 1.737 1.700 -0.125
ENSG00000227057 E033 22.9562512 0.0006097859 0.1557868394 0.421853694 6 33289102 33289247 146 - 1.414 1.329 -0.293

Help

Please Click HERE to learn more details about the results from DEXseq.