ENSG00000256269

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000442944 ENSG00000256269 No_inf pgKDN_inf HMBS protein_coding protein_coding 23.14119 14.60132 27.99258 2.983036 1.386488 0.9384732 0.3964319 0.9044963 0.2847994 0.9044963 0.28479941 -1.633244 0.04827500 0.132975 0.011850 -0.121125 0.96932934 0.00184893 FALSE TRUE
ENST00000536185 ENSG00000256269 No_inf pgKDN_inf HMBS protein_coding protein_coding_CDS_not_defined 23.14119 14.60132 27.99258 2.983036 1.386488 0.9384732 6.7221730 3.6872786 7.2661980 2.6413392 4.27223979 0.976721 0.26304167 0.198400 0.247775 0.049375 1.00000000 0.00184893   FALSE
ENST00000543821 ENSG00000256269 No_inf pgKDN_inf HMBS protein_coding retained_intron 23.14119 14.60132 27.99258 2.983036 1.386488 0.9384732 2.6214268 1.7346868 6.1295936 1.7346868 3.75004603 1.815175 0.10932500 0.102400 0.225575 0.123175 0.87505811 0.00184893 FALSE TRUE
ENST00000546302 ENSG00000256269 No_inf pgKDN_inf HMBS protein_coding protein_coding 23.14119 14.60132 27.99258 2.983036 1.386488 0.9384732 0.3031583 0.9094748 0.0000000 0.9094748 0.00000000 -6.522738 0.01789167 0.053675 0.000000 -0.053675 0.79463307 0.00184893 FALSE FALSE
ENST00000648488 ENSG00000256269 No_inf pgKDN_inf HMBS protein_coding nonsense_mediated_decay 23.14119 14.60132 27.99258 2.983036 1.386488 0.9384732 0.5043528 1.5130585 0.0000000 0.9183494 0.00000000 -7.250828 0.03343333 0.100300 0.000000 -0.100300 0.03623029 0.00184893 TRUE TRUE
ENST00000652429 ENSG00000256269 No_inf pgKDN_inf HMBS protein_coding protein_coding 23.14119 14.60132 27.99258 2.983036 1.386488 0.9384732 7.4649635 2.0871289 6.8115749 1.2108230 2.46059817 1.701689 0.29001667 0.110700 0.253475 0.142775 0.79771492 0.00184893 FALSE TRUE
ENST00000691144 ENSG00000256269 No_inf pgKDN_inf HMBS protein_coding retained_intron 23.14119 14.60132 27.99258 2.983036 1.386488 0.9384732 0.3163931 0.5998004 0.0839295 0.1493180 0.04851167 -2.698687 0.02411667 0.058975 0.003250 -0.055725 0.17074014 0.00184893 FALSE TRUE
MSTRG.5650.10 ENSG00000256269 No_inf pgKDN_inf HMBS protein_coding   23.14119 14.60132 27.99258 2.983036 1.386488 0.9384732 1.1367397 0.0000000 3.0127061 0.0000000 0.98933509 8.239697 0.04015000 0.000000 0.106775 0.106775 0.00184893 0.00184893 TRUE TRUE
MSTRG.5650.16 ENSG00000256269 No_inf pgKDN_inf HMBS protein_coding   23.14119 14.60132 27.99258 2.983036 1.386488 0.9384732 0.2912247 0.8736740 0.0000000 0.8736740 0.00000000 -6.465442 0.02117500 0.063525 0.000000 -0.063525 0.81011991 0.00184893 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000256269 E001 0.0000000       11 119084866 119084880 15 +      
ENSG00000256269 E002 0.0000000       11 119084881 119084882 2 +      
ENSG00000256269 E003 0.1272623 0.012202264 2.987988e-01   11 119084883 119084884 2 + 0.000 0.122 10.693
ENSG00000256269 E004 0.1272623 0.012202264 2.987988e-01   11 119084885 119084887 3 + 0.000 0.122 13.208
ENSG00000256269 E005 0.2442663 0.016095034 6.669540e-01   11 119084888 119084888 1 + 0.073 0.122 0.821
ENSG00000256269 E006 0.5969775 0.196627103 5.069071e-01 0.7656123290 11 119084889 119084897 9 + 0.240 0.122 -1.178
ENSG00000256269 E007 1.3330461 0.072535694 9.708694e-01 0.9942611935 11 119084898 119084899 2 + 0.360 0.362 0.014
ENSG00000256269 E008 1.6976497 0.058620210 9.211532e-01 0.9754269744 11 119084900 119084906 7 + 0.424 0.419 -0.027
ENSG00000256269 E009 1.8249121 0.118459066 9.186334e-01 0.9743996150 11 119084907 119084908 2 + 0.424 0.470 0.236
ENSG00000256269 E010 1.8249121 0.118459066 9.186334e-01 0.9743996150 11 119084909 119084910 2 + 0.424 0.470 0.236
ENSG00000256269 E011 2.6716587 0.059865847 9.763299e-01 0.9960072421 11 119084911 119084913 3 + 0.554 0.557 0.013
ENSG00000256269 E012 2.6716587 0.059865847 9.763299e-01 0.9960072421 11 119084914 119084914 1 + 0.554 0.557 0.013
ENSG00000256269 E013 4.1316772 0.009263666 8.510936e-01 0.9472660247 11 119084915 119084929 15 + 0.687 0.718 0.129
ENSG00000256269 E014 7.0211033 0.040966449 5.914929e-01 0.8193758713 11 119084930 119084998 69 + 0.913 0.856 -0.217
ENSG00000256269 E015 5.0663370 0.002948191 2.747293e-01 0.5681520146 11 119084999 119085030 32 + 0.815 0.691 -0.501
ENSG00000256269 E016 4.2118408 0.014695269 1.834808e-01 0.4603791968 11 119085031 119085039 9 + 0.763 0.594 -0.710
ENSG00000256269 E017 6.5078034 0.037078130 2.478630e-01 0.5386077503 11 119085040 119085066 27 + 0.913 0.769 -0.558
ENSG00000256269 E018 0.8354434 0.018417761 2.011790e-01 0.4833996007 11 119085067 119085157 91 + 0.323 0.122 -1.764
ENSG00000256269 E019 0.0000000       11 119085222 119085222 1 +      
ENSG00000256269 E020 0.0000000       11 119085223 119085243 21 +      
ENSG00000256269 E021 0.1170040 0.011808966 1.000000e+00   11 119085244 119085270 27 + 0.073 0.000 -12.281
ENSG00000256269 E022 0.2441403 0.016286061 6.657052e-01   11 119085271 119085289 19 + 0.073 0.122 0.821
ENSG00000256269 E023 0.6255190 0.014914245 4.965420e-02 0.2198366136 11 119085290 119085539 250 + 0.073 0.362 2.821
ENSG00000256269 E024 1.2434226 0.010361137 3.318706e-02 0.1731432865 11 119085540 119085782 243 + 0.191 0.516 2.043
ENSG00000256269 E025 0.2438580 0.016318092 6.649999e-01   11 119085783 119085810 28 + 0.073 0.122 0.821
ENSG00000256269 E026 0.4983826 0.016733633 1.235470e-01   11 119085811 119085893 83 + 0.073 0.296 2.406
ENSG00000256269 E027 2.7558348 0.023837637 3.192281e-05 0.0009090417 11 119087266 119087982 717 + 0.240 0.836 2.991
ENSG00000256269 E028 0.1271363 0.012372301 2.983860e-01   11 119087983 119087983 1 + 0.000 0.122 13.208
ENSG00000256269 E029 0.1271363 0.012372301 2.983860e-01   11 119087984 119087986 3 + 0.000 0.122 13.208
ENSG00000256269 E030 0.1271363 0.012372301 2.983860e-01   11 119087987 119087994 8 + 0.000 0.122 13.208
ENSG00000256269 E031 0.2536433 0.016545914 1.030663e-01   11 119087995 119088078 84 + 0.000 0.218 14.093
ENSG00000256269 E032 0.1265070 0.012399827 2.982905e-01   11 119088079 119088174 96 + 0.000 0.122 13.208
ENSG00000256269 E033 0.0000000       11 119088175 119088178 4 +      
ENSG00000256269 E034 0.3703650 0.017018403 2.964631e-01   11 119088179 119088253 75 + 0.073 0.218 1.821
ENSG00000256269 E035 0.3703650 0.017018403 2.964631e-01   11 119088254 119088254 1 + 0.073 0.218 1.821
ENSG00000256269 E036 11.6092973 0.123429601 6.291687e-01 0.8409767240 11 119088255 119088308 54 + 1.106 1.057 -0.178
ENSG00000256269 E037 0.2533610 0.016570984 1.028717e-01   11 119088309 119088385 77 + 0.000 0.218 14.093
ENSG00000256269 E038 0.2539903 0.016572196 1.029519e-01   11 119088386 119088634 249 + 0.000 0.218 14.093
ENSG00000256269 E039 12.8294690 0.108257313 4.551810e-01 0.7277875788 11 119088635 119088707 73 + 1.149 1.093 -0.200
ENSG00000256269 E040 0.2530140 0.305291318 1.491167e-01   11 119088708 119088848 141 + 0.000 0.218 13.819
ENSG00000256269 E041 0.7515852 0.381684988 9.193373e-02 0.3148771234 11 119088849 119089081 233 + 0.073 0.419 3.141
ENSG00000256269 E042 5.4357848 0.063068874 3.712020e-01 0.6592817707 11 119089082 119089099 18 + 0.839 0.718 -0.479
ENSG00000256269 E043 6.2820968 0.020106026 2.979546e-01 0.5909490687 11 119089100 119089131 32 + 0.893 0.769 -0.482
ENSG00000256269 E044 0.3628408 0.016804461 1.000000e+00   11 119089132 119089216 85 + 0.136 0.122 -0.179
ENSG00000256269 E045 9.0845738 0.045790082 7.009127e-01 0.8781801960 11 119089217 119089272 56 + 1.009 0.961 -0.180
ENSG00000256269 E046 9.4459728 0.099812479 7.287935e-01 0.8918757627 11 119089683 119089760 78 + 1.017 0.990 -0.097
ENSG00000256269 E047 0.0000000       11 119089761 119089775 15 +      
ENSG00000256269 E048 0.2373413 0.015684840 5.051300e-01   11 119089776 119089989 214 + 0.136 0.000 -13.150
ENSG00000256269 E049 11.0544371 0.001568190 6.957448e-01 0.8758152007 11 119089990 119090067 78 + 1.054 1.093 0.143
ENSG00000256269 E050 10.1359713 0.001443346 8.052619e-02 0.2915027695 11 119090190 119090265 76 + 0.968 1.126 0.577
ENSG00000256269 E051 0.7454479 0.014377596 1.373420e-01 0.3944949605 11 119091163 119091256 94 + 0.136 0.362 1.821
ENSG00000256269 E052 9.9486112 0.001439348 9.916824e-01 1.0000000000 11 119091413 119091526 114 + 1.024 1.032 0.027
ENSG00000256269 E053 0.2442663 0.016095034 6.669540e-01   11 119091527 119091537 11 + 0.073 0.122 0.821
ENSG00000256269 E054 0.9771576 0.083943681 4.757324e-01 0.7423589218 11 119091538 119091860 323 + 0.240 0.362 0.822
ENSG00000256269 E055 0.0000000       11 119091861 119091874 14 +      
ENSG00000256269 E056 0.8442338 0.042453246 6.725428e-01 0.8644459633 11 119091875 119092124 250 + 0.283 0.218 -0.501
ENSG00000256269 E057 4.9751077 0.008365318 7.521472e-01 0.9024169162 11 119092125 119092163 39 + 0.748 0.793 0.177
ENSG00000256269 E058 3.4929137 0.004273580 3.109015e-01 0.6040404697 11 119092164 119092403 240 + 0.687 0.557 -0.571
ENSG00000256269 E059 11.4658646 0.001945113 2.147300e-01 0.5002482398 11 119092404 119092523 120 + 1.119 1.018 -0.366
ENSG00000256269 E060 0.3802764 0.025965570 3.387574e-02   11 119092524 119092610 87 + 0.000 0.296 14.582
ENSG00000256269 E061 0.7608997 0.021576074 1.302117e-03 0.0183555546 11 119092611 119092757 147 + 0.000 0.470 15.411
ENSG00000256269 E062 8.1371801 0.001805197 6.963865e-01 0.8760457270 11 119092758 119092811 54 + 0.932 0.976 0.164
ENSG00000256269 E063 0.2438580 0.016318092 6.649999e-01   11 119092812 119092934 123 + 0.073 0.122 0.821
ENSG00000256269 E064 10.9374830 0.001277372 6.344758e-01 0.8437729333 11 119092935 119093021 87 + 1.046 1.093 0.169
ENSG00000256269 E065 25.0052420 0.017897646 2.022947e-01 0.4847200410 11 119093110 119093834 725 + 1.437 1.339 -0.340

Help

Please Click HERE to learn more details about the results from DEXseq.