ENSG00000257727

Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000273308 ENSG00000257727 No_inf pgKDN_inf CNPY2 protein_coding protein_coding 80.13551 70.23704 74.17276 4.147127 8.750919 0.07864658 1.383653 4.1509605 0.000000 2.4511953 0.0000000 -8.7007728 0.01886667 0.056600 0.000000 -0.056600 0.47181585 0.01237348 FALSE  
ENST00000546937 ENSG00000257727 No_inf pgKDN_inf CNPY2 protein_coding retained_intron 80.13551 70.23704 74.17276 4.147127 8.750919 0.07864658 4.777749 7.4624106 3.159098 0.7582989 0.5963725 -1.2375016 0.06473333 0.107325 0.046000 -0.061325 0.25139086 0.01237348    
ENST00000547570 ENSG00000257727 No_inf pgKDN_inf CNPY2 protein_coding retained_intron 80.13551 70.23704 74.17276 4.147127 8.750919 0.07864658 3.279033 6.3570160 0.000000 2.5007666 0.0000000 -9.3144736 0.04199167 0.086275 0.000000 -0.086275 0.01237348 0.01237348    
ENST00000548013 ENSG00000257727 No_inf pgKDN_inf CNPY2 protein_coding retained_intron 80.13551 70.23704 74.17276 4.147127 8.750919 0.07864658 4.245656 0.9356814 7.686109 0.9356814 0.8766713 3.0247031 0.05344167 0.015925 0.104700 0.088775 0.02394056 0.01237348    
ENST00000551475 ENSG00000257727 No_inf pgKDN_inf CNPY2 protein_coding protein_coding 80.13551 70.23704 74.17276 4.147127 8.750919 0.07864658 20.981716 15.9192852 19.595112 2.4176175 6.9896156 0.2995484 0.24537500 0.224900 0.236100 0.011200 0.96682097 0.01237348 FALSE  
ENST00000553191 ENSG00000257727 No_inf pgKDN_inf CNPY2 protein_coding nonsense_mediated_decay 80.13551 70.23704 74.17276 4.147127 8.750919 0.07864658 2.612915 4.6827162 0.000000 2.7075032 0.0000000 -8.8742794 0.03018333 0.063200 0.000000 -0.063200 0.47081050 0.01237348    
MSTRG.6670.41 ENSG00000257727 No_inf pgKDN_inf CNPY2 protein_coding   80.13551 70.23704 74.17276 4.147127 8.750919 0.07864658 4.839118 2.3553702 4.262502 1.8686931 2.2797598 0.8530152 0.06047500 0.033250 0.063675 0.030425 0.82818222 0.01237348 TRUE  
MSTRG.6670.45 ENSG00000257727 No_inf pgKDN_inf CNPY2 protein_coding   80.13551 70.23704 74.17276 4.147127 8.750919 0.07864658 33.181743 23.3723875 37.136847 3.4254937 2.2856102 0.6678175 0.42574167 0.344150 0.518550 0.174400 0.37784584 0.01237348 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results from IsoformSwitchAnalyzeR.