ENSG00000133706

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000274562 ENSG00000133706 pgwt_inf pgKDN_inf LARS1 protein_coding protein_coding 59.44374 71.63905 70.34835 1.945352 0.8135668 -0.02622592 21.653146 26.794613 22.177527 0.6127917 1.4666421 -0.27273247 0.376500 0.374800 0.314825 -0.059975 0.886982403 0.001440287 FALSE TRUE
ENST00000394434 ENSG00000133706 pgwt_inf pgKDN_inf LARS1 protein_coding protein_coding 59.44374 71.63905 70.34835 1.945352 0.8135668 -0.02622592 12.454809 13.236140 14.137377 1.0271339 0.7107820 0.09496257 0.220375 0.185250 0.201150 0.015900 0.932211051 0.001440287 FALSE TRUE
ENST00000508667 ENSG00000133706 pgwt_inf pgKDN_inf LARS1 protein_coding retained_intron 59.44374 71.63905 70.34835 1.945352 0.8135668 -0.02622592 7.853166 9.310978 7.928471 1.8283536 0.8628591 -0.23162019 0.138150 0.128250 0.112775 -0.015475 0.954603501 0.001440287 FALSE TRUE
ENST00000510191 ENSG00000133706 pgwt_inf pgKDN_inf LARS1 protein_coding protein_coding 59.44374 71.63905 70.34835 1.945352 0.8135668 -0.02622592 8.786809 8.561748 17.798678 2.2880710 2.1103279 1.05491914 0.123575 0.117700 0.253025 0.135325 0.342710143 0.001440287 FALSE TRUE
MSTRG.23717.20 ENSG00000133706 pgwt_inf pgKDN_inf LARS1 protein_coding   59.44374 71.63905 70.34835 1.945352 0.8135668 -0.02622592 1.723345 5.170034 0.000000 2.1855348 0.0000000 -9.01681780 0.024925 0.074775 0.000000 -0.074775 0.001440287 0.001440287 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf pgwt.inf log2fold_pgwt.inf_pgKDN.inf
ENSG00000133706 E001 1.4990512 0.1822179078 0.3125602601   5 146110566 146113033 2468 - 0.481 0.291 -1.087
ENSG00000133706 E002 0.2359573 0.0156778262 0.2643599710   5 146113034 146113042 9 - 0.000 0.170 10.019
ENSG00000133706 E003 62.2938885 0.0003648950 0.9395687301 0.99581299 5 146113043 146113895 853 - 1.802 1.800 -0.008
ENSG00000133706 E004 7.5222940 0.0018704096 0.7143161868 0.96779455 5 146113896 146113910 15 - 0.948 0.912 -0.135
ENSG00000133706 E005 114.1914085 0.0035764744 0.1168818836 0.72494668 5 146113911 146114232 322 - 2.032 2.089 0.192
ENSG00000133706 E006 27.5867714 0.0005309943 0.1441964245 0.76464043 5 146114233 146114311 79 - 1.413 1.496 0.286
ENSG00000133706 E007 0.0000000       5 146119009 146119074 66 -      
ENSG00000133706 E008 47.6559696 0.0003126228 0.3621925342 0.89533854 5 146120371 146120503 133 - 1.667 1.707 0.136
ENSG00000133706 E009 76.3339436 0.0002226199 0.4744007071 0.92065707 5 146122492 146122587 96 - 1.876 1.901 0.085
ENSG00000133706 E010 0.0000000       5 146123979 146123981 3 -      
ENSG00000133706 E011 67.6457140 0.0002246219 0.0186951361 0.43747512 5 146123982 146124086 105 - 1.792 1.878 0.291
ENSG00000133706 E012 63.8512368 0.0002382704 0.1884138319 0.80569404 5 146126435 146126545 111 - 1.787 1.836 0.168
ENSG00000133706 E013 70.2237354 0.0004122392 0.6993424200 0.96465870 5 146128672 146128779 108 - 1.845 1.860 0.049
ENSG00000133706 E014 29.6886100 0.0005483610 0.2919305981 0.86944052 5 146128780 146128782 3 - 1.457 1.516 0.200
ENSG00000133706 E015 68.2676448 0.0002926137 0.4646322475 0.91976138 5 146128978 146129081 104 - 1.853 1.827 -0.087
ENSG00000133706 E016 38.2424521 0.0007519728 0.3818749337 0.89997397 5 146129082 146129118 37 - 1.614 1.572 -0.143
ENSG00000133706 E017 73.5059797 0.0002125488 0.8832476403 0.98984707 5 146130018 146130158 141 - 1.874 1.870 -0.015
ENSG00000133706 E018 2.6008381 0.1197117389 0.5845764679   5 146130159 146130867 709 - 0.607 0.498 -0.502
ENSG00000133706 E019 0.8780053 0.0140040802 0.2231429538   5 146130868 146130935 68 - 0.356 0.170 -1.409
ENSG00000133706 E020 1.1251251 0.0117348736 0.2769701835   5 146130936 146131018 83 - 0.402 0.235 -1.087
ENSG00000133706 E021 46.7213231 0.0006499347 0.5187691053 0.93046335 5 146131019 146131109 91 - 1.692 1.664 -0.095
ENSG00000133706 E022 14.5093810 0.0009988517 0.0208147739 0.44993643 5 146131110 146132897 1788 - 1.094 1.271 0.630
ENSG00000133706 E023 66.5292707 0.0002476395 0.6415419612 0.95056070 5 146132898 146133081 184 - 1.838 1.821 -0.055
ENSG00000133706 E024 30.7416196 0.0103873607 0.6920860939 0.96364897 5 146135601 146135664 64 - 1.487 1.516 0.097
ENSG00000133706 E025 0.0000000       5 146139616 146139703 88 -      
ENSG00000133706 E026 27.8555236 0.0005184413 0.7395966947 0.96974549 5 146140204 146140261 58 - 1.469 1.451 -0.062
ENSG00000133706 E027 36.6848799 0.0010171639 0.0001285141 0.02921848 5 146140262 146142855 2594 - 1.469 1.664 0.667
ENSG00000133706 E028 1.9854624 0.0092650894 0.5386884829   5 146142856 146142871 16 - 0.517 0.427 -0.450
ENSG00000133706 E029 35.9218494 0.0004163936 0.2924629412 0.86980441 5 146142872 146142990 119 - 1.592 1.540 -0.177
ENSG00000133706 E030 32.1359017 0.0004819755 0.8483768545 0.98519339 5 146142991 146143084 94 - 1.525 1.516 -0.032
ENSG00000133706 E031 1.0720205 0.0109102794 0.0178218354   5 146143085 146143105 21 - 0.098 0.464 2.912
ENSG00000133706 E032 2.0674026 0.0065148655 0.2797590957   5 146143244 146143411 168 - 0.402 0.560 0.787
ENSG00000133706 E033 31.0672498 0.0007774598 0.5415674853 0.93514816 5 146143412 146143486 75 - 1.522 1.490 -0.110
ENSG00000133706 E034 30.4444423 0.0005829028 0.6727790451 0.95759834 5 146143487 146143550 64 - 1.508 1.486 -0.076
ENSG00000133706 E035 37.1285396 0.0037412038 0.4527394736 0.91831158 5 146144267 146144349 83 - 1.600 1.561 -0.135
ENSG00000133706 E036 0.7513785 0.1303425770 0.4282765064   5 146144350 146144471 122 - 0.304 0.170 -1.088
ENSG00000133706 E037 39.1644458 0.0004932065 0.7433488076 0.97014931 5 146144472 146144537 66 - 1.611 1.596 -0.051
ENSG00000133706 E038 1.2099411 0.0263895534 0.2480848279   5 146144538 146144623 86 - 0.246 0.427 1.135
ENSG00000133706 E039 30.4390994 0.0006997218 0.0617001209 0.62277062 5 146144624 146144662 39 - 1.544 1.443 -0.346
ENSG00000133706 E040 35.3870316 0.0066044107 0.1052144539 0.71239419 5 146144663 146144709 47 - 1.606 1.509 -0.330
ENSG00000133706 E041 10.3673720 0.0116032613 0.6430705670 0.95089368 5 146144710 146146511 1802 - 1.076 1.033 -0.156
ENSG00000133706 E042 7.5983237 0.0021961580 0.4458558743 0.91690971 5 146146512 146148199 1688 - 0.895 0.971 0.287
ENSG00000133706 E043 3.7978837 0.0294453335 0.5159292686 0.93002640 5 146148200 146149551 1352 - 0.634 0.724 0.382
ENSG00000133706 E044 1.7072499 0.0094763649 0.3444543888   5 146149552 146149621 70 - 0.356 0.498 0.760
ENSG00000133706 E045 31.2847751 0.0004626150 0.1196829596 0.72977943 5 146149622 146149657 36 - 1.547 1.465 -0.282
ENSG00000133706 E046 32.5611594 0.0004680648 0.5315748498 0.93363656 5 146149658 146149699 42 - 1.541 1.509 -0.109
ENSG00000133706 E047 0.2455451 0.0164437677 0.9615391155   5 146151500 146151861 362 - 0.098 0.093 -0.087
ENSG00000133706 E048 49.1271670 0.0002860079 0.2215816412 0.82774286 5 146151862 146152002 141 - 1.725 1.673 -0.175
ENSG00000133706 E049 23.4372293 0.0005890782 0.0255584583 0.48694386 5 146153174 146153227 54 - 1.450 1.314 -0.471
ENSG00000133706 E050 26.0100162 0.0023411649 0.6222134653 0.94828741 5 146153734 146153810 77 - 1.446 1.416 -0.101
ENSG00000133706 E051 27.5021111 0.0067363748 0.5678333985 0.94003571 5 146153893 146153980 88 - 1.473 1.436 -0.126
ENSG00000133706 E052 0.0000000       5 146157397 146157402 6 -      
ENSG00000133706 E053 51.5926331 0.0003196249 0.8443873225 0.98465143 5 146157403 146157628 226 - 1.725 1.717 -0.026
ENSG00000133706 E054 21.2423818 0.0130112814 0.4775444330 0.92111981 5 146157728 146157795 68 - 1.373 1.319 -0.188
ENSG00000133706 E055 20.6346525 0.0102841755 0.4280055098 0.91311636 5 146159407 146159470 64 - 1.363 1.304 -0.209
ENSG00000133706 E056 26.0378145 0.0165326188 0.7180006021 0.96779455 5 146160374 146160486 113 - 1.446 1.416 -0.102
ENSG00000133706 E057 0.9645661 0.0188650375 0.1814475172   5 146162528 146164309 1782 - 0.178 0.386 1.497
ENSG00000133706 E058 30.1689114 0.0005235773 0.1561988476 0.77743733 5 146164310 146164471 162 - 1.454 1.531 0.266
ENSG00000133706 E059 13.7826067 0.0010007697 0.9609321026 0.99674816 5 146168128 146168147 20 - 1.168 1.172 0.016
ENSG00000133706 E060 28.3448205 0.0005613693 0.6406543022 0.95056070 5 146168148 146168265 118 - 1.480 1.455 -0.087
ENSG00000133706 E061 23.4200934 0.0007477426 0.6716245007 0.95705439 5 146171910 146171990 81 - 1.400 1.375 -0.088
ENSG00000133706 E062 25.1345354 0.0006353390 0.8702802133 0.98772073 5 146172687 146172774 88 - 1.421 1.412 -0.031
ENSG00000133706 E063 26.5280161 0.0154266187 0.4379938952 0.91616936 5 146177547 146177665 119 - 1.409 1.469 0.207
ENSG00000133706 E064 0.1176775 0.0116208027 0.5723485676   5 146181012 146181187 176 - 0.000 0.093 9.019
ENSG00000133706 E065 0.4820297 0.0275387642 0.3531065206   5 146182140 146182475 336 - 0.098 0.235 1.498
ENSG00000133706 E066 20.7787707 0.0007763683 0.1881668329 0.80540960 5 146182488 146182561 74 - 1.377 1.293 -0.294
ENSG00000133706 E067 12.6186915 0.0014775020 0.1988518243 0.81265835 5 146182562 146182621 60 - 1.182 1.079 -0.371
ENSG00000133706 E068 3.4607865 0.0041046909 0.5926356250   5 146182622 146182696 75 - 0.682 0.613 -0.294

Help

Please Click HERE to learn more details about the results from DEXseq.